The genetics of gestational diabetes mellitus: evidence for relationship with type 2 diabetes mellitus
Gestational diabetes is a major public health problem because of its prevalence, its associated complications during pregnancy, and its increased risk for type 2 diabetes later in life. Insulin resistance is one of many physiological changes occurring during pregnancy, and when insulin resistance is...
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| Veröffentlicht in: | Genetics in medicine 2008-04, Vol.10 (4), p.240-250 |
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| creator | Robitaille, Julie Grant, Althea M. |
| description | Gestational diabetes is a major public health problem because of its prevalence, its associated complications during pregnancy, and its increased risk for type 2 diabetes later in life. Insulin resistance is one of many physiological changes occurring during pregnancy, and when insulin resistance is accompanied by pancreatic β-cell insufficiency, gestational diabetes may develop. Several lines of evidence suggest that gestational diabetes shares a common etiology with type 2 diabetes and support the hypothesis that gestational diabetes serves as a window to reveal a predisposition to type 2 diabetes. Pregnancy is an environmental stressor that may catalyze the progression to a diabetic state in genetically predisposed women; therefore, identification of these women during pregnancy could decrease the occurrence of type 2 diabetes through targeted prevention. This review presents an overview of the genetics of gestational diabetes, focusing on human association studies with candidate genes common to both type 2 diabetes and gestational diabetes. |
| doi_str_mv | 10.1097/GIM.0b013e31816b8710 |
| format | Article |
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| ispartof | Genetics in medicine, 2008-04, Vol.10 (4), p.240-250 |
| issn | 1098-3600 1530-0366 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | association studies Biomedical and Life Sciences Biomedicine Diabetes Mellitus, Type 2 - genetics Diabetes, Gestational - genetics Female Genetic Predisposition to Disease - genetics genetics gestational diabetes mellitus Glucose - metabolism Human Genetics Humans Insulin - metabolism Laboratory Medicine Lipid Metabolism - genetics Mutation - genetics Pregnancy review Risk Factors Signal Transduction - genetics type 2 diabetes |
| title | The genetics of gestational diabetes mellitus: evidence for relationship with type 2 diabetes mellitus |
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