Targeted disruption of cocaine-activated nucleus accumbens neurons prevents context-specific sensitization

Until now, no tools existed to selectively manipulate the small number of sparsely distributed neurons activated during a drug-related learned behavior. Here the authors describe a new method for selectively inactivating only those neurons activated by cocaine in an environment repeatedly paired wit...

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Veröffentlicht in:	Nature neuroscience 2009-08, Vol.12 (8), p.1069-1073
Hauptverfasser:	Koya, Eisuke, Golden, Sam A, Harvey, Brandon K, Guez-Barber, Danielle H, Berkow, Alexander, Simmons, Danielle E, Bossert, Jennifer M, Nair, Sunila G, Uejima, Jamie L, Marin, Marcelo T, Mitchell, Timothy B, Farquhar, David, Ghosh, Sukhen C, Mattson, Brandi J, Hope, Bruce T
Format:	Artikel
Sprache:	eng
Schlagworte:	Addiction Animal Genetics and Genomics Animals Behavior Behavior, Animal - drug effects Behavior, Animal - physiology Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Cocaine Cocaine - pharmacology Cocaine-Related Disorders - physiopathology Cues Daunorubicin - toxicity Disease Models, Animal Dopamine Uptake Inhibitors - pharmacology Dosage and administration Drugs Learning - drug effects Learning - physiology Male Neurobiology Neuronal Plasticity - drug effects Neuronal Plasticity - physiology Neurons Neurons - drug effects Neurons - physiology Neuropharmacology - methods Neurosciences Neurotoxins - toxicity Nucleus Accumbens - drug effects Nucleus Accumbens - physiology Physiological aspects Psychological aspects Psychomotor Performance - drug effects Psychomotor Performance - physiology Rats Rats, Sprague-Dawley Rats, Transgenic Roles technical-report
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