Bone healing after dental extractions in irradiated patients: a pilot study on a novel technique for volume assessment of healing tooth sockets
The aim of this study was to evaluate longitudinally the bone-healing process by measuring volumetric changes of the extraction sockets in head and neck cancer patients undergoing radiotherapy after tooth extraction. A total group of 15 patients (nine males, six females) undergoing tooth extraction...
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| Veröffentlicht in: | Clinical oral investigations 2009-09, Vol.13 (3), p.257-261 |
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| creator | Agbaje, Jimoh Olubanwo Jacobs, Reinhilde Michiels, Katleen Abu-Ta’a, Mahmoud van Steenberghe, Daniel |
| description | The aim of this study was to evaluate longitudinally the bone-healing process by measuring volumetric changes of the extraction sockets in head and neck cancer patients undergoing radiotherapy after tooth extraction. A total group of 15 patients (nine males, six females) undergoing tooth extraction at the Department of Periodontology (University Hospital KULeuven) were enrolled after giving informed consent. In seven patients, teeth presenting a risk for complications and eventual radionecrosis were extracted prior to the radiotherapeutical procedure. Monitoring of bone healing was performed by evaluating the volumetric changes of the alveoli by cone beam CT scanning (CBCT) at extraction and after 3 and 6 months. In parallel, a similar longitudinal evaluation of extraction sites was done in a control group of eight patients. Within this pilot-study, a total of 15 healing extraction sockets were evaluated and followed up. There was a significant difference in volumetric fill up of extraction sockets in test group vs. control group at three (37.1 ± 7.9%) vs. (54.6 ± 4.0%) and 6 months (47.2 ± 8.8%) vs. (70.0 ± 7.3%), respectively. The present pilot study demonstrated the clinical usefulness of CBCT for evaluation of extraction socket healing. The study objectively demonstrates the delayed bone healing after tooth extraction in irradiated head and neck cancer patients. Considering the limitations of this pilot study, a potential effect of radiotherapy on further jaw bone healing after pre-therapeutic tooth extractions should be further explored. |
| doi_str_mv | 10.1007/s00784-008-0231-7 |
| format | Article |
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A total group of 15 patients (nine males, six females) undergoing tooth extraction at the Department of Periodontology (University Hospital KULeuven) were enrolled after giving informed consent. In seven patients, teeth presenting a risk for complications and eventual radionecrosis were extracted prior to the radiotherapeutical procedure. Monitoring of bone healing was performed by evaluating the volumetric changes of the alveoli by cone beam CT scanning (CBCT) at extraction and after 3 and 6 months. In parallel, a similar longitudinal evaluation of extraction sites was done in a control group of eight patients. Within this pilot-study, a total of 15 healing extraction sockets were evaluated and followed up. There was a significant difference in volumetric fill up of extraction sockets in test group vs. control group at three (37.1 ± 7.9%) vs. (54.6 ± 4.0%) and 6 months (47.2 ± 8.8%) vs. (70.0 ± 7.3%), respectively. The present pilot study demonstrated the clinical usefulness of CBCT for evaluation of extraction socket healing. The study objectively demonstrates the delayed bone healing after tooth extraction in irradiated head and neck cancer patients. Considering the limitations of this pilot study, a potential effect of radiotherapy on further jaw bone healing after pre-therapeutic tooth extractions should be further explored.</description><identifier>ISSN: 1432-6981</identifier><identifier>EISSN: 1436-3771</identifier><identifier>DOI: 10.1007/s00784-008-0231-7</identifier><identifier>PMID: 18985394</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Aged ; Bone Regeneration - radiation effects ; Case-Control Studies ; Cone-Beam Computed Tomography ; Cranial Irradiation - adverse effects ; Dentistry ; Female ; Humans ; Laryngeal Neoplasms - radiotherapy ; Male ; Medicine ; Middle Aged ; Mouth Neoplasms - radiotherapy ; Original Article ; Pilot Projects ; Tooth Extraction ; Tooth Socket - diagnostic imaging ; Tooth Socket - physiology ; Tooth Socket - radiation effects ; Wound Healing - radiation effects</subject><ispartof>Clinical oral investigations, 2009-09, Vol.13 (3), p.257-261</ispartof><rights>Springer-Verlag 2008</rights><rights>Springer-Verlag 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-d95684270af2bdb36be78c7340f537c5143a9530718de1a3c563b12029519fdd3</citedby><cites>FETCH-LOGICAL-c400t-d95684270af2bdb36be78c7340f537c5143a9530718de1a3c563b12029519fdd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00784-008-0231-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00784-008-0231-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18985394$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Agbaje, Jimoh Olubanwo</creatorcontrib><creatorcontrib>Jacobs, Reinhilde</creatorcontrib><creatorcontrib>Michiels, Katleen</creatorcontrib><creatorcontrib>Abu-Ta’a, Mahmoud</creatorcontrib><creatorcontrib>van Steenberghe, Daniel</creatorcontrib><title>Bone healing after dental extractions in irradiated patients: a pilot study on a novel technique for volume assessment of healing tooth sockets</title><title>Clinical oral investigations</title><addtitle>Clin Oral Invest</addtitle><addtitle>Clin Oral Investig</addtitle><description>The aim of this study was to evaluate longitudinally the bone-healing process by measuring volumetric changes of the extraction sockets in head and neck cancer patients undergoing radiotherapy after tooth extraction. A total group of 15 patients (nine males, six females) undergoing tooth extraction at the Department of Periodontology (University Hospital KULeuven) were enrolled after giving informed consent. In seven patients, teeth presenting a risk for complications and eventual radionecrosis were extracted prior to the radiotherapeutical procedure. Monitoring of bone healing was performed by evaluating the volumetric changes of the alveoli by cone beam CT scanning (CBCT) at extraction and after 3 and 6 months. In parallel, a similar longitudinal evaluation of extraction sites was done in a control group of eight patients. Within this pilot-study, a total of 15 healing extraction sockets were evaluated and followed up. There was a significant difference in volumetric fill up of extraction sockets in test group vs. control group at three (37.1 ± 7.9%) vs. (54.6 ± 4.0%) and 6 months (47.2 ± 8.8%) vs. (70.0 ± 7.3%), respectively. The present pilot study demonstrated the clinical usefulness of CBCT for evaluation of extraction socket healing. The study objectively demonstrates the delayed bone healing after tooth extraction in irradiated head and neck cancer patients. Considering the limitations of this pilot study, a potential effect of radiotherapy on further jaw bone healing after pre-therapeutic tooth extractions should be further explored.</description><subject>Adult</subject><subject>Aged</subject><subject>Bone Regeneration - radiation effects</subject><subject>Case-Control Studies</subject><subject>Cone-Beam Computed Tomography</subject><subject>Cranial Irradiation - adverse effects</subject><subject>Dentistry</subject><subject>Female</subject><subject>Humans</subject><subject>Laryngeal Neoplasms - radiotherapy</subject><subject>Male</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - radiotherapy</subject><subject>Original Article</subject><subject>Pilot Projects</subject><subject>Tooth Extraction</subject><subject>Tooth Socket - diagnostic imaging</subject><subject>Tooth Socket - physiology</subject><subject>Tooth Socket - radiation effects</subject><subject>Wound Healing - radiation effects</subject><issn>1432-6981</issn><issn>1436-3771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kc1u1TAQhSMEoqXwAGyQxYJdwH-JbXa04k-qxAbWlmNPel0S--JxKvoUvDIu94pKSGxsa_ydMzM6Xfec0deMUvUG26FlT6nuKResVw-6UybF2Aul2MM_b96PRrOT7gniNaVMjko87k6YNnoQRp52v85zArIDt8R0RdxcoZAAqbqFwM9anK8xJyQxkViKC9FVCGTvamwMviWO7OOSK8G6hVuSUyukfAMLqeB3Kf7YgMy5kJu8bCsQhwiIa5OSPP9tWnOuO4LZf4eKT7tHs1sQnh3vs-7bh_dfLz71l18-fr54d9l7SWntgxlGLbmibuZTmMQ4gdJeCUnnQSg_tM2dGQRVTAdgTvhhFBPjlJuBmTkEcda9OvjuS25TYrVrRA_L4hLkDS2nRihuZANf_gNe562kNpvl3IxcajM2iB0gXzJigdnuS1xdubWM2ruo7CEq26Kyd1FZ1TQvjsbbtEK4VxyzaQA_ANi-0hWU-87_d_0NPlKgPg</recordid><startdate>20090901</startdate><enddate>20090901</enddate><creator>Agbaje, Jimoh Olubanwo</creator><creator>Jacobs, Reinhilde</creator><creator>Michiels, Katleen</creator><creator>Abu-Ta’a, Mahmoud</creator><creator>van Steenberghe, Daniel</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7QP</scope></search><sort><creationdate>20090901</creationdate><title>Bone healing after dental extractions in irradiated patients: a pilot study on a novel technique for volume assessment of healing tooth sockets</title><author>Agbaje, Jimoh Olubanwo ; Jacobs, Reinhilde ; Michiels, Katleen ; Abu-Ta’a, Mahmoud ; van Steenberghe, Daniel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-d95684270af2bdb36be78c7340f537c5143a9530718de1a3c563b12029519fdd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Bone Regeneration - radiation effects</topic><topic>Case-Control Studies</topic><topic>Cone-Beam Computed Tomography</topic><topic>Cranial Irradiation - adverse effects</topic><topic>Dentistry</topic><topic>Female</topic><topic>Humans</topic><topic>Laryngeal Neoplasms - radiotherapy</topic><topic>Male</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - radiotherapy</topic><topic>Original Article</topic><topic>Pilot Projects</topic><topic>Tooth Extraction</topic><topic>Tooth Socket - diagnostic imaging</topic><topic>Tooth Socket - physiology</topic><topic>Tooth Socket - radiation effects</topic><topic>Wound Healing - radiation effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Agbaje, Jimoh Olubanwo</creatorcontrib><creatorcontrib>Jacobs, Reinhilde</creatorcontrib><creatorcontrib>Michiels, Katleen</creatorcontrib><creatorcontrib>Abu-Ta’a, Mahmoud</creatorcontrib><creatorcontrib>van Steenberghe, Daniel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>Clinical oral investigations</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Agbaje, Jimoh Olubanwo</au><au>Jacobs, Reinhilde</au><au>Michiels, Katleen</au><au>Abu-Ta’a, Mahmoud</au><au>van Steenberghe, Daniel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone healing after dental extractions in irradiated patients: a pilot study on a novel technique for volume assessment of healing tooth sockets</atitle><jtitle>Clinical oral investigations</jtitle><stitle>Clin Oral Invest</stitle><addtitle>Clin Oral Investig</addtitle><date>2009-09-01</date><risdate>2009</risdate><volume>13</volume><issue>3</issue><spage>257</spage><epage>261</epage><pages>257-261</pages><issn>1432-6981</issn><eissn>1436-3771</eissn><abstract>The aim of this study was to evaluate longitudinally the bone-healing process by measuring volumetric changes of the extraction sockets in head and neck cancer patients undergoing radiotherapy after tooth extraction. A total group of 15 patients (nine males, six females) undergoing tooth extraction at the Department of Periodontology (University Hospital KULeuven) were enrolled after giving informed consent. In seven patients, teeth presenting a risk for complications and eventual radionecrosis were extracted prior to the radiotherapeutical procedure. Monitoring of bone healing was performed by evaluating the volumetric changes of the alveoli by cone beam CT scanning (CBCT) at extraction and after 3 and 6 months. In parallel, a similar longitudinal evaluation of extraction sites was done in a control group of eight patients. Within this pilot-study, a total of 15 healing extraction sockets were evaluated and followed up. There was a significant difference in volumetric fill up of extraction sockets in test group vs. control group at three (37.1 ± 7.9%) vs. (54.6 ± 4.0%) and 6 months (47.2 ± 8.8%) vs. (70.0 ± 7.3%), respectively. The present pilot study demonstrated the clinical usefulness of CBCT for evaluation of extraction socket healing. The study objectively demonstrates the delayed bone healing after tooth extraction in irradiated head and neck cancer patients. Considering the limitations of this pilot study, a potential effect of radiotherapy on further jaw bone healing after pre-therapeutic tooth extractions should be further explored.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>18985394</pmid><doi>10.1007/s00784-008-0231-7</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1432-6981 |
| ispartof | Clinical oral investigations, 2009-09, Vol.13 (3), p.257-261 |
| issn | 1432-6981 1436-3771 |
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| source | MEDLINE; Springer Journals |
| subjects | Adult Aged Bone Regeneration - radiation effects Case-Control Studies Cone-Beam Computed Tomography Cranial Irradiation - adverse effects Dentistry Female Humans Laryngeal Neoplasms - radiotherapy Male Medicine Middle Aged Mouth Neoplasms - radiotherapy Original Article Pilot Projects Tooth Extraction Tooth Socket - diagnostic imaging Tooth Socket - physiology Tooth Socket - radiation effects Wound Healing - radiation effects |
| title | Bone healing after dental extractions in irradiated patients: a pilot study on a novel technique for volume assessment of healing tooth sockets |
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