Nucleolar localization of TERT is unrelated to telomerase function in human cells

Telomerase maintains telomere length and has been implicated in both aging and carcinogenesis of human cells. This enzyme is a specialized ribonucleoprotein (RNP) complex, minimally consisting of two essential components: the protein catalytic subunit TERT (telomerase reverse transcriptase) and the...

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Veröffentlicht in:	Journal of cell science 2008-07, Vol.121 (13), p.2169-2176
Hauptverfasser:	Lin, Jian, Jin, Rui, Zhang, Bin, Chen, Hao, Bai, Yun Xiu, Yang, Ping Xun, Han, Su Wen, Xie, Yao Hua, Huang, Pei Tang, Huang, Cuifen, Huang, Jun Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Catalytic Domain Cell Line Cell Nucleolus - metabolism Humans Mice Nuclear Localization Signals - genetics Nuclear Localization Signals - metabolism Ribonucleoproteins - genetics Ribonucleoproteins - metabolism RNA - genetics RNA - metabolism Sequence Homology, Amino Acid Telomerase - genetics Telomerase - metabolism Telomere - genetics Telomere - metabolism
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