Structural brain maturation differs between preterm and term piglets, whereas brain activity does not
Aim The aim of the study was to investigate whether amplitude‐integrated electroencephalography (aEEG) and cerebral magnetic resonance imaging (MRI) in preterm piglets would provide measures of cerebral functional, microstructural and anatomical maturation, which might reflect the signs of functiona...
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| Veröffentlicht in: | Acta Paediatrica 2019-04, Vol.108 (4), p.637-644 |
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| container_title | Acta Paediatrica |
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| creator | Plomgaard, A M Andersen, A D Petersen, T H Looij, Y Thymann, T Sangild, P T Thomsen, C Sizonenko, S V Greisen, G |
| description | Aim
The aim of the study was to investigate whether amplitude‐integrated electroencephalography (aEEG) and cerebral magnetic resonance imaging (MRI) in preterm piglets would provide measures of cerebral functional, microstructural and anatomical maturation, which might reflect the signs of functional brain immaturity, documented in preterm piglets.
Methods
During July–October 2013 at the NEOMUNE Centre, Copenhagen University, Denmark, 31 preterm (90% gestation) and 10 term piglets underwent aEEG on days 1, 2, 4 and 11, and MRI on day 25. Physical activity levels were recorded.
Results
Preterm showed delayed neonatal arousal and physical activity, relative to term piglets. Preterm piglets had lower growth rates and brain volume than term piglets, but aEEG patterns were similar. MRI mean diffusivity was also similar, but fractional anisotropy (FA) was lower in preterm piglets (p < 0.001).
Conclusion
Functional brain maturation, as assessed by aEEG, was relatively advanced in preterm piglets. Conversely, the low FA in the preterm piglets suggests that the white matter microstructure remains less mature in preterm compared to term piglets at postnatal day 25. The results might be utilised to define whether and how preterm piglets may contribute to preclinical models for brain development in preterm infants. |
| doi_str_mv | 10.1111/apa.14556 |
| format | Article |
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The aim of the study was to investigate whether amplitude‐integrated electroencephalography (aEEG) and cerebral magnetic resonance imaging (MRI) in preterm piglets would provide measures of cerebral functional, microstructural and anatomical maturation, which might reflect the signs of functional brain immaturity, documented in preterm piglets.
Methods
During July–October 2013 at the NEOMUNE Centre, Copenhagen University, Denmark, 31 preterm (90% gestation) and 10 term piglets underwent aEEG on days 1, 2, 4 and 11, and MRI on day 25. Physical activity levels were recorded.
Results
Preterm showed delayed neonatal arousal and physical activity, relative to term piglets. Preterm piglets had lower growth rates and brain volume than term piglets, but aEEG patterns were similar. MRI mean diffusivity was also similar, but fractional anisotropy (FA) was lower in preterm piglets (p < 0.001).
Conclusion
Functional brain maturation, as assessed by aEEG, was relatively advanced in preterm piglets. Conversely, the low FA in the preterm piglets suggests that the white matter microstructure remains less mature in preterm compared to term piglets at postnatal day 25. The results might be utilised to define whether and how preterm piglets may contribute to preclinical models for brain development in preterm infants.</description><identifier>ISSN: 0803-5253</identifier><identifier>EISSN: 1651-2227</identifier><identifier>DOI: 10.1111/apa.14556</identifier><identifier>PMID: 30144173</identifier><language>eng</language><publisher>Norway: Wiley Subscription Services, Inc</publisher><subject>Animal models ; Anisotropy ; Arousal ; Attention deficit hyperactivity disorder ; Brain ; EEG ; Electroencephalography ; Gestation ; Growth rate ; Infants ; Magnetic resonance imaging ; Maturation ; Microstructure ; Neonates ; Neuroimaging ; NMR ; Nuclear magnetic resonance ; Physical activity ; Premature babies ; Preterm infant brain model ; Preterm piglet and piglet model ; Substantia alba</subject><ispartof>Acta Paediatrica, 2019-04, Vol.108 (4), p.637-644</ispartof><rights>2018 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd</rights><rights>2018 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.</rights><rights>2019 Foundation Acta Pædiatrica</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3536-e87c52d5a94aeaf76dec49188509996f6c387edf38767d8ba12fc4b9eacce5d23</citedby><cites>FETCH-LOGICAL-c3536-e87c52d5a94aeaf76dec49188509996f6c387edf38767d8ba12fc4b9eacce5d23</cites><orcidid>0000-0002-1009-6013</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fapa.14556$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fapa.14556$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30144173$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Plomgaard, A M</creatorcontrib><creatorcontrib>Andersen, A D</creatorcontrib><creatorcontrib>Petersen, T H</creatorcontrib><creatorcontrib>Looij, Y</creatorcontrib><creatorcontrib>Thymann, T</creatorcontrib><creatorcontrib>Sangild, P T</creatorcontrib><creatorcontrib>Thomsen, C</creatorcontrib><creatorcontrib>Sizonenko, S V</creatorcontrib><creatorcontrib>Greisen, G</creatorcontrib><title>Structural brain maturation differs between preterm and term piglets, whereas brain activity does not</title><title>Acta Paediatrica</title><addtitle>Acta Paediatr</addtitle><description>Aim
The aim of the study was to investigate whether amplitude‐integrated electroencephalography (aEEG) and cerebral magnetic resonance imaging (MRI) in preterm piglets would provide measures of cerebral functional, microstructural and anatomical maturation, which might reflect the signs of functional brain immaturity, documented in preterm piglets.
Methods
During July–October 2013 at the NEOMUNE Centre, Copenhagen University, Denmark, 31 preterm (90% gestation) and 10 term piglets underwent aEEG on days 1, 2, 4 and 11, and MRI on day 25. Physical activity levels were recorded.
Results
Preterm showed delayed neonatal arousal and physical activity, relative to term piglets. Preterm piglets had lower growth rates and brain volume than term piglets, but aEEG patterns were similar. MRI mean diffusivity was also similar, but fractional anisotropy (FA) was lower in preterm piglets (p < 0.001).
Conclusion
Functional brain maturation, as assessed by aEEG, was relatively advanced in preterm piglets. Conversely, the low FA in the preterm piglets suggests that the white matter microstructure remains less mature in preterm compared to term piglets at postnatal day 25. The results might be utilised to define whether and how preterm piglets may contribute to preclinical models for brain development in preterm infants.</description><subject>Animal models</subject><subject>Anisotropy</subject><subject>Arousal</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Brain</subject><subject>EEG</subject><subject>Electroencephalography</subject><subject>Gestation</subject><subject>Growth rate</subject><subject>Infants</subject><subject>Magnetic resonance imaging</subject><subject>Maturation</subject><subject>Microstructure</subject><subject>Neonates</subject><subject>Neuroimaging</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Physical activity</subject><subject>Premature babies</subject><subject>Preterm infant brain model</subject><subject>Preterm piglet and piglet model</subject><subject>Substantia alba</subject><issn>0803-5253</issn><issn>1651-2227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kNtLHTEQh0NR9FR96D9QAr604B5z383jQXoRBIXW55BNZm1kb02yPZz_3j0X-yA4DzMJfHwz_BD6RMmSznVtR7ukQkr1AS2okrRgjJVHaEEqwgvJJD9FH1N6JoRxLdQJOuWECkFLvkDwK8fJ5SnaFtfRhh53dvvLYeixD00DMeEa8hqgx2OEDLHDtvd49xjDUws5XeH1H4hg00FhXQ7_Qt5gP0DC_ZDP0XFj2wQXh3mGHr9_-33zs7i7_3F7s7orHJdcFVCVTjIvrRYWbFMqD05oWlWSaK1VoxyvSvDN3FXpq9pS1jhRa7DOgfSMn6Eve-8Yh78TpGy6kBy0re1hmJJhRHNBiBJyRi_foM_DFPv5OsNoNW-jmm6FX_eUi0NKERozxtDZuDGUmG32Zs7e7LKf2c8H41R34P-Tr2HPwPUeWIcWNu-bzOphtVe-AISOjrc</recordid><startdate>201904</startdate><enddate>201904</enddate><creator>Plomgaard, A M</creator><creator>Andersen, A D</creator><creator>Petersen, T H</creator><creator>Looij, Y</creator><creator>Thymann, T</creator><creator>Sangild, P T</creator><creator>Thomsen, C</creator><creator>Sizonenko, S V</creator><creator>Greisen, G</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1009-6013</orcidid></search><sort><creationdate>201904</creationdate><title>Structural brain maturation differs between preterm and term piglets, whereas brain activity does not</title><author>Plomgaard, A M ; Andersen, A D ; Petersen, T H ; Looij, Y ; Thymann, T ; Sangild, P T ; Thomsen, C ; Sizonenko, S V ; Greisen, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3536-e87c52d5a94aeaf76dec49188509996f6c387edf38767d8ba12fc4b9eacce5d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animal models</topic><topic>Anisotropy</topic><topic>Arousal</topic><topic>Attention deficit hyperactivity disorder</topic><topic>Brain</topic><topic>EEG</topic><topic>Electroencephalography</topic><topic>Gestation</topic><topic>Growth rate</topic><topic>Infants</topic><topic>Magnetic resonance imaging</topic><topic>Maturation</topic><topic>Microstructure</topic><topic>Neonates</topic><topic>Neuroimaging</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Physical activity</topic><topic>Premature babies</topic><topic>Preterm infant brain model</topic><topic>Preterm piglet and piglet model</topic><topic>Substantia alba</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Plomgaard, A M</creatorcontrib><creatorcontrib>Andersen, A D</creatorcontrib><creatorcontrib>Petersen, T H</creatorcontrib><creatorcontrib>Looij, Y</creatorcontrib><creatorcontrib>Thymann, T</creatorcontrib><creatorcontrib>Sangild, P T</creatorcontrib><creatorcontrib>Thomsen, C</creatorcontrib><creatorcontrib>Sizonenko, S V</creatorcontrib><creatorcontrib>Greisen, G</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Acta Paediatrica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Plomgaard, A M</au><au>Andersen, A D</au><au>Petersen, T H</au><au>Looij, Y</au><au>Thymann, T</au><au>Sangild, P T</au><au>Thomsen, C</au><au>Sizonenko, S V</au><au>Greisen, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structural brain maturation differs between preterm and term piglets, whereas brain activity does not</atitle><jtitle>Acta Paediatrica</jtitle><addtitle>Acta Paediatr</addtitle><date>2019-04</date><risdate>2019</risdate><volume>108</volume><issue>4</issue><spage>637</spage><epage>644</epage><pages>637-644</pages><issn>0803-5253</issn><eissn>1651-2227</eissn><abstract>Aim
The aim of the study was to investigate whether amplitude‐integrated electroencephalography (aEEG) and cerebral magnetic resonance imaging (MRI) in preterm piglets would provide measures of cerebral functional, microstructural and anatomical maturation, which might reflect the signs of functional brain immaturity, documented in preterm piglets.
Methods
During July–October 2013 at the NEOMUNE Centre, Copenhagen University, Denmark, 31 preterm (90% gestation) and 10 term piglets underwent aEEG on days 1, 2, 4 and 11, and MRI on day 25. Physical activity levels were recorded.
Results
Preterm showed delayed neonatal arousal and physical activity, relative to term piglets. Preterm piglets had lower growth rates and brain volume than term piglets, but aEEG patterns were similar. MRI mean diffusivity was also similar, but fractional anisotropy (FA) was lower in preterm piglets (p < 0.001).
Conclusion
Functional brain maturation, as assessed by aEEG, was relatively advanced in preterm piglets. Conversely, the low FA in the preterm piglets suggests that the white matter microstructure remains less mature in preterm compared to term piglets at postnatal day 25. The results might be utilised to define whether and how preterm piglets may contribute to preclinical models for brain development in preterm infants.</abstract><cop>Norway</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30144173</pmid><doi>10.1111/apa.14556</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-1009-6013</orcidid></addata></record> |
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| ispartof | Acta Paediatrica, 2019-04, Vol.108 (4), p.637-644 |
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| source | Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Animal models Anisotropy Arousal Attention deficit hyperactivity disorder Brain EEG Electroencephalography Gestation Growth rate Infants Magnetic resonance imaging Maturation Microstructure Neonates Neuroimaging NMR Nuclear magnetic resonance Physical activity Premature babies Preterm infant brain model Preterm piglet and piglet model Substantia alba |
| title | Structural brain maturation differs between preterm and term piglets, whereas brain activity does not |
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