Topical application of a novel ceramide derivative, K6PC-9, inhibits dust mite extract-induced atopic dermatitis-like skin lesions in NC/Nga mice

Atopic dermatitis (AD) is a chronic inflammatory skin disease. K6PC-9 (N-Ethanol-2-hexyl-3-oxo-decanamide) is a novel synthetic ceramide derivative of PC-9S (N-Ethanol-2-mirystyl-3-oxo-stearamide), which was known to be effective in atopic and psoriatic patients. To investigate the immunomodulatory...

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Veröffentlicht in:	International immunopharmacology 2007-12, Vol.7 (13), p.1589-1597
Hauptverfasser:	Kang, Jong Soon, Youm, Jong-Kyung, Jeong, Se Kyoo, Park, Byeong Deog, Yoon, Won Kee, Han, Mi Hwa, Lee, Hyunju, Han, Sang-Bae, Lee, Kiho, Park, Song-Kyu, Lee, Seung Hun, Yang, Kyu-Hwan, Moon, Eun-Yi, Kim, Hwan Mook
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion molecule Administration, Cutaneous Allergic diseases Animals Atopic dermatitis Biological and medical sciences Ceramides - administration & dosage Dermatitis, Atopic - etiology Dermatitis, Atopic - metabolism Dermatitis, Atopic - prevention & control Dermatophagoides Female Immunopathology Intercellular Adhesion Molecule-1 - genetics K6PC-9 Lymphocyte Activation - drug effects Medical sciences Mice Mice, Inbred BALB C Pharmacology. Drug treatments Pyroglyphidae - immunology RNA, Messenger - analysis Skin allergic diseases. Stinging insect allergies Skin inflammation T-Lymphocytes - drug effects T-Lymphocytes - immunology Tetradecanoylphorbol Acetate - toxicity TNF-α Tumor Necrosis Factor-alpha - genetics Vascular Cell Adhesion Molecule-1 - genetics
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