Endothelial Dab1 signaling orchestrates neuro-glia-vessel communication in the central nervous system

The architecture of the neurovascular unit (NVU) is controlled by the communication of neurons, glia, and vascular cells. We found that the neuronal guidance cue reelin possesses proangiogenic activities that ensure the communication of endothelial cells (ECs) with the glia to control neuronal migra...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2018-08, Vol.361 (6404)
Hauptverfasser:	Segarra, Marta, Aburto, Maria R, Cop, Florian, Llaó-Cid, Cecília, Härtl, Ricarda, Damm, Miriam, Bethani, Ioanna, Parrilla, Marta, Husainie, Dewi, Schänzer, Anne, Schlierbach, Hannah, Acker, Till, Mohr, Laura, Torres-Masjoan, Laia, Ritter, Mathias, Acker-Palmer, Amparo
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Anatomy Animals Apolipoprotein E Apolipoproteins Architecture Astrocytes Axon guidance Blood vessels Blood-brain barrier Brain Brain architecture Cell migration Cell proliferation Central nervous system Cerebral cortex Clonal deletion Communication Communications systems Defects Disabled-1 protein Docking Embryos Endothelial cells Endothelium Extracellular matrix Filopodia Glycoproteins Growth factors Homeostasis Individualized Instruction Integrity Laminin Membrane permeability Mice Migration Nervous system Networks Neural networks Neuronal-glial interactions Neurons Nutrients Permeability Receptors Retina Secretion Stimuli Vascular endothelial growth factor Vascular system
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