Searching for improved mimetic peptides inhibitors preventing conformational transition of amyloid-β42 monomer

[Display omitted] •A novel mimetic peptide that inhibits Aβ cytotoxicity at submicromolar concentration is reported.•Antiaggregant activities were measured using different biophysical assays.•Complex formation and its dynamic behaviour was analysed using docking and enhanced sampling MD.•Docking pos...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Bioorganic chemistry 2018-12, Vol.81, p.211-221
Hauptverfasser:	Gera, János, Szögi, Titanilla, Bozsó, Zsolt, Fülöp, Livia, Barrera, Exequiel E., Rodriguez, Ana M., Méndez, Luciana, Delpiccolo, Carina M.L., Mata, Ernesto G., Cioffi, Federica, Broersen, Kerensa, Paragi, Gabor, Enriz, Ricardo D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer’s disease Amyloid β-peptide Aβ aggregation Mimetic peptides Molecular docking Molecular dynamics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!