Neprilysin degrades murine Amyloid-β (Aβ) more efficiently than human Aβ: Further implication for species-specific amyloid accumulation

•All types of NEP degrade murine Aβ faster than human Aβ.•Faster NEP-mediated turnover of murine Aβ could further explain species-specific Aβ aggregation.•Aβ4–15 is an effective tool to study peptidase activity towards Aβ1–40 and Aβ1–42. For over a century, aggregated forms of amyloid-β protein (Aβ)...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Neuroscience letters 2018-11, Vol.686, p.74-79
Hauptverfasser:	Becker, Matthias, Moore, Andrew, Naughton, Maura, Boland, Barry, Siems, Wolf-Eberhard, Walther, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer’s disease Amyloid-β protein Catabolism Neprilysin Neuroscience Neutral endopeptidase
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!