Early-life growth of preterm infants and its impact on neurodevelopment
Background Increasing numbers of preterm-born children survive nowadays, and improving long-term health and neurodevelopment is becoming more important. Early-life growth has been linked to neurodevelopmental outcomes. We aimed to study whether this association has changed with time. Methods We stud...
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| Veröffentlicht in: | Pediatric research 2019-02, Vol.85 (3), p.283-292 |
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| creator | Ruys, Charlotte A. Hollanders, Jonneke J. Bröring, Tinka van Schie, Petra E. M. van der Pal, Sylvia M. van de Lagemaat, Monique Lafeber, Harrie N. Rotteveel, Joost Finken, Martijn J. J. |
| description | Background
Increasing numbers of preterm-born children survive nowadays, and improving long-term health and neurodevelopment is becoming more important. Early-life growth has been linked to neurodevelopmental outcomes. We aimed to study whether this association has changed with time.
Methods
We studied two cohorts of preterm-born children (gestational age ≤32 weeks and/or birth weight ≤1500 g) from 1983 (
n
= 708) and 2003–2006 (
n
= 138), respectively. We distinguished four early-life growth patterns at 3 months corrected age: appropriate for gestational age (AGA) with or without growth restriction (AGA GR+/AGA GR−), and small for gestational age (SGA) with or without catch-up growth (SGA CUG+/SGA CUG−). Intelligence quotient (IQ), neuromotor function, and behavior were assessed at ages 19 and 8 years, respectively, for the cohorts.
Results
In the 2003–2006 cohort, less children had early-life GR. In both cohorts, SGA CUG− subjects had unfavorable growth trajectories and neurodevelopmental outcomes (IQ
β
−6.5, 95% confidence interval (CI) −9.8; −3.2,
P
|
| doi_str_mv | 10.1038/s41390-018-0139-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2093310131</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2093310131</sourcerecordid><originalsourceid>FETCH-LOGICAL-c481t-7d57224332618527db8eac3b317096d9c3de333bf52beec9597644ae30beeae33</originalsourceid><addsrcrecordid>eNp1kMtKxTAQhoMoerw8gBspuHFTnWTSk2YpokdBcKPrkLZTrbRJTVrFtzdyvIDgIvyZ5JtJ-Bg75HDKAcuzKDlqyIGXaaHOYYMteIHpREq1yRYAyHPUutxhuzE-A3BZlHKb7WDaAShYsNWlDf173nctZY_Bv01PmW-zMdBEYcg611o3xcy6JutSdsNo6ynzLnM0B9_QK_V-HMhN-2yrtX2kg6_cYw9Xl_cX1_nt3erm4vw2r2XJp1w1hRJCIoolLwuhmqokW2OFXIFeNrrGhhCxagtREdW60GoppSWEVKbAPXaynjsG_zJTnMzQxZr63jryczQCNCJPNnhCj_-gz34OLv3OCF5ypRQKlSi-purgYwzUmjF0gw3vhoP5tGzWlk2ybD4tG0g9R1-T52qg5qfjW2sCxBqI6co9Uvh9-v-pH-uUhk0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2181777327</pqid></control><display><type>article</type><title>Early-life growth of preterm infants and its impact on neurodevelopment</title><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Ruys, Charlotte A. ; Hollanders, Jonneke J. ; Bröring, Tinka ; van Schie, Petra E. M. ; van der Pal, Sylvia M. ; van de Lagemaat, Monique ; Lafeber, Harrie N. ; Rotteveel, Joost ; Finken, Martijn J. J.</creator><creatorcontrib>Ruys, Charlotte A. ; Hollanders, Jonneke J. ; Bröring, Tinka ; van Schie, Petra E. M. ; van der Pal, Sylvia M. ; van de Lagemaat, Monique ; Lafeber, Harrie N. ; Rotteveel, Joost ; Finken, Martijn J. J.</creatorcontrib><description>Background
Increasing numbers of preterm-born children survive nowadays, and improving long-term health and neurodevelopment is becoming more important. Early-life growth has been linked to neurodevelopmental outcomes. We aimed to study whether this association has changed with time.
Methods
We studied two cohorts of preterm-born children (gestational age ≤32 weeks and/or birth weight ≤1500 g) from 1983 (
n
= 708) and 2003–2006 (
n
= 138), respectively. We distinguished four early-life growth patterns at 3 months corrected age: appropriate for gestational age (AGA) with or without growth restriction (AGA GR+/AGA GR−), and small for gestational age (SGA) with or without catch-up growth (SGA CUG+/SGA CUG−). Intelligence quotient (IQ), neuromotor function, and behavior were assessed at ages 19 and 8 years, respectively, for the cohorts.
Results
In the 2003–2006 cohort, less children had early-life GR. In both cohorts, SGA CUG− subjects had unfavorable growth trajectories and neurodevelopmental outcomes (IQ
β
−6.5, 95% confidence interval (CI) −9.8; −3.2,
P
< 0.001; neuromotor score
β
−1.9%, 95% CI −3.2; −0.6,
P
= 0.005), while SGA CUG+ subjects were comparable to adequately grown subjects.
Conclusion
Although the incidence of adverse growth patterns decreased between the cohorts, possibly indicating improvements in care over time, the impact of these growth patterns on neurodevelopmental outcomes was not significantly different. Achieving adequate early-life growth may be crucial for improving neurodevelopmental outcomes, especially for preterms born SGA.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1038/s41390-018-0139-0</identifier><identifier>PMID: 30140070</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Age ; Clinical Research Article ; Medicine ; Medicine & Public Health ; Pediatric Surgery ; Pediatrics ; Premature babies</subject><ispartof>Pediatric research, 2019-02, Vol.85 (3), p.283-292</ispartof><rights>International Pediatric Research Foundation, Inc. 2018</rights><rights>Copyright Nature Publishing Group Feb 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-7d57224332618527db8eac3b317096d9c3de333bf52beec9597644ae30beeae33</citedby><cites>FETCH-LOGICAL-c481t-7d57224332618527db8eac3b317096d9c3de333bf52beec9597644ae30beeae33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30140070$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ruys, Charlotte A.</creatorcontrib><creatorcontrib>Hollanders, Jonneke J.</creatorcontrib><creatorcontrib>Bröring, Tinka</creatorcontrib><creatorcontrib>van Schie, Petra E. M.</creatorcontrib><creatorcontrib>van der Pal, Sylvia M.</creatorcontrib><creatorcontrib>van de Lagemaat, Monique</creatorcontrib><creatorcontrib>Lafeber, Harrie N.</creatorcontrib><creatorcontrib>Rotteveel, Joost</creatorcontrib><creatorcontrib>Finken, Martijn J. J.</creatorcontrib><title>Early-life growth of preterm infants and its impact on neurodevelopment</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><addtitle>Pediatr Res</addtitle><description>Background
Increasing numbers of preterm-born children survive nowadays, and improving long-term health and neurodevelopment is becoming more important. Early-life growth has been linked to neurodevelopmental outcomes. We aimed to study whether this association has changed with time.
Methods
We studied two cohorts of preterm-born children (gestational age ≤32 weeks and/or birth weight ≤1500 g) from 1983 (
n
= 708) and 2003–2006 (
n
= 138), respectively. We distinguished four early-life growth patterns at 3 months corrected age: appropriate for gestational age (AGA) with or without growth restriction (AGA GR+/AGA GR−), and small for gestational age (SGA) with or without catch-up growth (SGA CUG+/SGA CUG−). Intelligence quotient (IQ), neuromotor function, and behavior were assessed at ages 19 and 8 years, respectively, for the cohorts.
Results
In the 2003–2006 cohort, less children had early-life GR. In both cohorts, SGA CUG− subjects had unfavorable growth trajectories and neurodevelopmental outcomes (IQ
β
−6.5, 95% confidence interval (CI) −9.8; −3.2,
P
< 0.001; neuromotor score
β
−1.9%, 95% CI −3.2; −0.6,
P
= 0.005), while SGA CUG+ subjects were comparable to adequately grown subjects.
Conclusion
Although the incidence of adverse growth patterns decreased between the cohorts, possibly indicating improvements in care over time, the impact of these growth patterns on neurodevelopmental outcomes was not significantly different. Achieving adequate early-life growth may be crucial for improving neurodevelopmental outcomes, especially for preterms born SGA.</description><subject>Age</subject><subject>Clinical Research Article</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Premature babies</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kMtKxTAQhoMoerw8gBspuHFTnWTSk2YpokdBcKPrkLZTrbRJTVrFtzdyvIDgIvyZ5JtJ-Bg75HDKAcuzKDlqyIGXaaHOYYMteIHpREq1yRYAyHPUutxhuzE-A3BZlHKb7WDaAShYsNWlDf173nctZY_Bv01PmW-zMdBEYcg611o3xcy6JutSdsNo6ynzLnM0B9_QK_V-HMhN-2yrtX2kg6_cYw9Xl_cX1_nt3erm4vw2r2XJp1w1hRJCIoolLwuhmqokW2OFXIFeNrrGhhCxagtREdW60GoppSWEVKbAPXaynjsG_zJTnMzQxZr63jryczQCNCJPNnhCj_-gz34OLv3OCF5ypRQKlSi-purgYwzUmjF0gw3vhoP5tGzWlk2ybD4tG0g9R1-T52qg5qfjW2sCxBqI6co9Uvh9-v-pH-uUhk0</recordid><startdate>20190201</startdate><enddate>20190201</enddate><creator>Ruys, Charlotte A.</creator><creator>Hollanders, Jonneke J.</creator><creator>Bröring, Tinka</creator><creator>van Schie, Petra E. M.</creator><creator>van der Pal, Sylvia M.</creator><creator>van de Lagemaat, Monique</creator><creator>Lafeber, Harrie N.</creator><creator>Rotteveel, Joost</creator><creator>Finken, Martijn J. J.</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20190201</creationdate><title>Early-life growth of preterm infants and its impact on neurodevelopment</title><author>Ruys, Charlotte A. ; Hollanders, Jonneke J. ; Bröring, Tinka ; van Schie, Petra E. M. ; van der Pal, Sylvia M. ; van de Lagemaat, Monique ; Lafeber, Harrie N. ; Rotteveel, Joost ; Finken, Martijn J. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-7d57224332618527db8eac3b317096d9c3de333bf52beec9597644ae30beeae33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Age</topic><topic>Clinical Research Article</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Premature babies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ruys, Charlotte A.</creatorcontrib><creatorcontrib>Hollanders, Jonneke J.</creatorcontrib><creatorcontrib>Bröring, Tinka</creatorcontrib><creatorcontrib>van Schie, Petra E. M.</creatorcontrib><creatorcontrib>van der Pal, Sylvia M.</creatorcontrib><creatorcontrib>van de Lagemaat, Monique</creatorcontrib><creatorcontrib>Lafeber, Harrie N.</creatorcontrib><creatorcontrib>Rotteveel, Joost</creatorcontrib><creatorcontrib>Finken, Martijn J. J.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ruys, Charlotte A.</au><au>Hollanders, Jonneke J.</au><au>Bröring, Tinka</au><au>van Schie, Petra E. M.</au><au>van der Pal, Sylvia M.</au><au>van de Lagemaat, Monique</au><au>Lafeber, Harrie N.</au><au>Rotteveel, Joost</au><au>Finken, Martijn J. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early-life growth of preterm infants and its impact on neurodevelopment</atitle><jtitle>Pediatric research</jtitle><stitle>Pediatr Res</stitle><addtitle>Pediatr Res</addtitle><date>2019-02-01</date><risdate>2019</risdate><volume>85</volume><issue>3</issue><spage>283</spage><epage>292</epage><pages>283-292</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><abstract>Background
Increasing numbers of preterm-born children survive nowadays, and improving long-term health and neurodevelopment is becoming more important. Early-life growth has been linked to neurodevelopmental outcomes. We aimed to study whether this association has changed with time.
Methods
We studied two cohorts of preterm-born children (gestational age ≤32 weeks and/or birth weight ≤1500 g) from 1983 (
n
= 708) and 2003–2006 (
n
= 138), respectively. We distinguished four early-life growth patterns at 3 months corrected age: appropriate for gestational age (AGA) with or without growth restriction (AGA GR+/AGA GR−), and small for gestational age (SGA) with or without catch-up growth (SGA CUG+/SGA CUG−). Intelligence quotient (IQ), neuromotor function, and behavior were assessed at ages 19 and 8 years, respectively, for the cohorts.
Results
In the 2003–2006 cohort, less children had early-life GR. In both cohorts, SGA CUG− subjects had unfavorable growth trajectories and neurodevelopmental outcomes (IQ
β
−6.5, 95% confidence interval (CI) −9.8; −3.2,
P
< 0.001; neuromotor score
β
−1.9%, 95% CI −3.2; −0.6,
P
= 0.005), while SGA CUG+ subjects were comparable to adequately grown subjects.
Conclusion
Although the incidence of adverse growth patterns decreased between the cohorts, possibly indicating improvements in care over time, the impact of these growth patterns on neurodevelopmental outcomes was not significantly different. Achieving adequate early-life growth may be crucial for improving neurodevelopmental outcomes, especially for preterms born SGA.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>30140070</pmid><doi>10.1038/s41390-018-0139-0</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-3998 |
| ispartof | Pediatric research, 2019-02, Vol.85 (3), p.283-292 |
| issn | 0031-3998 1530-0447 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2093310131 |
| source | EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Age Clinical Research Article Medicine Medicine & Public Health Pediatric Surgery Pediatrics Premature babies |
| title | Early-life growth of preterm infants and its impact on neurodevelopment |
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