Valproate sensitizes human glioblastoma cells to 3-bromopyruvate-induced cytotoxicity

[Display omitted] Glioblastoma (GBM) is the most common brain tumor; however, no effective treatment for it is available yet. Monocarboxylate transporters, which are highly expressed in GBM, play a role in transporting antitumor agents, such as 3-bromopyruvate (3-BrPA). Valproate, primarily used to...

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Veröffentlicht in:	International journal of pharmaceutics 2018-11, Vol.551 (1-2), p.97-102
Hauptverfasser:	Ishiguro, Yuri, Kobayashi, Masaki, Ideno, Masaya, Narumi, Katsuya, Furugen, Ayako, Iseki, Ken
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Bromopyruvate Adenosine Triphosphate - metabolism Antineoplastic Agents - administration & dosage ATP-binding cassette transporter ATP-Binding Cassette Transporters - genetics Brain Neoplasms - drug therapy Brain Neoplasms - metabolism Cell Line, Tumor Cell Survival - drug effects Glioblastoma Glioblastoma - drug therapy Glioblastoma - metabolism Humans Monocarboxylate transporter Pyruvates - administration & dosage RNA, Messenger - metabolism Valproate Valproic Acid - administration & dosage
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