Palmitate treated-astrocyte conditioned medium contains increased glutathione and interferes in hypothalamic synaptic network in vitro

Excessive fat consumption increases the level of fatty acids (FAs) in the blood, which reach the hypothalamus and damage the circuit related to energy balance. In the present study, we used palmitate in a primary culture of purified astrocytes to mimic the fat-rich environment found in obesity. Our...

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Veröffentlicht in:	Neurochemistry international 2018-11, Vol.120, p.140-148
Hauptverfasser:	Oliveira, Ariadne de Almeida Branco, Melo, Nayara de Freitas Martins, Vieira, Érica dos Santos, Nogueira, Pedro Augusto Silva, Coope, Andressa, Velloso, Lício Augusto, Dezonne, Rômulo Sperduto, Ueira-Vieira, Carlos, Botelho, Francoise Vasconcelos, Gomes, Juliana de Assis Silva, Zanon, Renata Graciele
Format:	Artikel
Sprache:	eng
Schlagworte:	Astrocyte Fatty acid Glutathione Hypothalamus Palmitate Synapse
Online-Zugang:	Volltext
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