Cytotoxic p‑Terphenyls from the Endolichenic Fungus Floricola striata
Eleven new p-terphenyls, floricolins K–U (1–11), together with 13 biosynthetically related known compounds (12–24) were isolated from an endolichenic fungus, Floricola striata. Their structures were elucidated by extensive spectroscopic analyses and single-crystal X-ray diffraction measurements. The...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2018-09, Vol.81 (9), p.2041-2049 |
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| container_end_page | 2049 |
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| container_issue | 9 |
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| container_title | Journal of natural products (Washington, D.C.) |
| container_volume | 81 |
| creator | Xu, Ke Gao, Yun Li, Yue-Lan Xie, Fei Zhao, Zun-Tian Lou, Hong-Xiang |
| description | Eleven new p-terphenyls, floricolins K–U (1–11), together with 13 biosynthetically related known compounds (12–24) were isolated from an endolichenic fungus, Floricola striata. Their structures were elucidated by extensive spectroscopic analyses and single-crystal X-ray diffraction measurements. The newly isolated p-terphenyls inhibited the growth of A2780, MCF-7, and A549 cell lines. Further evaluation for the multidrug resistance (MDR) reversal activity of compound 5 revealed it enhanced the sensitivity of MCF-7/ADR cells toward adriamycin 39-fold at 10 μM through modulating P-glycoprotein-mediated drug exclusion. |
| doi_str_mv | 10.1021/acs.jnatprod.8b00362 |
| format | Article |
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Nat. Prod</addtitle><date>2018-09-28</date><risdate>2018</risdate><volume>81</volume><issue>9</issue><spage>2041</spage><epage>2049</epage><pages>2041-2049</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><abstract>Eleven new p-terphenyls, floricolins K–U (1–11), together with 13 biosynthetically related known compounds (12–24) were isolated from an endolichenic fungus, Floricola striata. Their structures were elucidated by extensive spectroscopic analyses and single-crystal X-ray diffraction measurements. The newly isolated p-terphenyls inhibited the growth of A2780, MCF-7, and A549 cell lines. 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| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 2018-09, Vol.81 (9), p.2041-2049 |
| issn | 0163-3864 1520-6025 |
| language | eng |
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| source | MEDLINE; ACS Publications |
| subjects | Ascomycota - metabolism Cell Line, Tumor Doxorubicin - pharmacokinetics Doxorubicin - pharmacology Drug Resistance, Multiple - drug effects Humans Terphenyl Compounds - chemistry Terphenyl Compounds - isolation & purification Terphenyl Compounds - pharmacology |
| title | Cytotoxic p‑Terphenyls from the Endolichenic Fungus Floricola striata |
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