IL4 gene delivery to the CNS recruits regulatory T cells and induces clinical recovery in mouse models of multiple sclerosis

Central nervous system (CNS) delivery of anti-inflammatory cytokines, such as interleukin 4 (IL4), holds promise as treatment for multiple sclerosis (MS). We have previously shown that short-term herpes simplex virus type 1-mediated IL4 gene therapy is able to inhibit experimental autoimmune encepha...

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Veröffentlicht in:	Gene therapy 2008-04, Vol.15 (7), p.504-515
Hauptverfasser:	Butti, E, Bergami, A, Recchia, A, Brambilla, E, Del Carro, U, Amadio, S, Cattalini, A, Esposito, M, Stornaiuolo, A, Comi, G, Pluchino, S, Mavilio, F, Martino, G, Furlan, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animal models Animals Applied cell therapy and gene therapy Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology CCL17 protein CCL22 protein CD25 antigen CD4 antigen CD69 antigen Cell Biology Central nervous system Central Nervous System - immunology Central Nervous System - pathology Cerebrospinal fluid Chemokines Chemokines - immunology Chemotaxis, Leukocyte Cytokines Disease Models, Animal Experimental allergic encephalomyelitis Female Foxp3 protein Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Gene transfer Genetic Therapy - methods Genetic Vectors - administration & dosage Green Fluorescent Proteins - analysis Green Fluorescent Proteins - genetics Health. Pharmaceutical industry Helper Viruses - genetics Herpes simplex Herpes simplex virus Human Genetics Humans Immunology Immunoregulation Industrial applications and implications. Economical aspects Inflammatory diseases Interleukin 4 Interleukin-4 - analysis Interleukin-4 - genetics Interleukin-4 - immunology Lymphocytes T Medical sciences Mice Mice, Inbred C57BL Multiple sclerosis Multiple Sclerosis - immunology Multiple Sclerosis - pathology Multiple Sclerosis - therapy Nanotechnology Neurology original-article Primates Reverse Transcriptase Polymerase Chain Reaction Rodents T-Lymphocytes, Regulatory - immunology Toxicity Transduction, Genetic - methods Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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