Interaction between Haemochromatosis and Transferrin Receptor Genes in Hepatocellular Carcinoma

In hepatocellular carcinoma (HCC) iron has been implicated as a risk factor primarily in patients with hereditary haemochromatosis (HH) and cirrhosis. The wild-type HH (HFE) protein complexes with the transferrin receptor (TFR), and two HFE mutations (Cys282Tyr and His63Asp) have been found to incre...

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Veröffentlicht in:	Oncology 2000-01, Vol.59 (4), p.317-322
Hauptverfasser:	Beckman, L.E., Hägerstrand, I., Stenling, R., van Landeghem, G.F., Beckman, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Carcinoma, Hepatocellular - genetics Female Gastroenterology. Liver. Pancreas. Abdomen Hemochromatosis - genetics Heterozygote Homozygote Humans Laboratory/Clinical Translational Research Liver Neoplasms - genetics Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Mutation Odds Ratio Other diseases. Semiology Receptors, Transferrin - genetics Risk Factors Tumors
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