The resistance to the tumor suppressive effects of COX inhibitors and COX-2 gene disruption in TRAMP mice is associated with the loss of COX expression in prostate tissue

Over-expression of cyclooxygenase-2 (COX-2) and prostaglandin E2 has been demonstrated to play a significant role in the tumorigenesis of colon, lung, breast, bladder and skin. However, inconsistent and controversial reports on the expression and activity of COX-2 in prostate cancer raised the quest...

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Veröffentlicht in:	Carcinogenesis (New York) 2008-01, Vol.29 (1), p.120-128
Hauptverfasser:	Wang, Xingya, Colby, Jennifer K.L., Yang, Peiying, Fischer, Susan M., Newman, Robert A., Klein, Russell D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Cyclooxygenase 2 - genetics Cyclooxygenase Inhibitors - pharmacology Immunohistochemistry Male Medical sciences Mice Mice, Transgenic Prostate - enzymology Prostatic Neoplasms - enzymology Reverse Transcriptase Polymerase Chain Reaction Tumors
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