Trimetazidine Induces Parkinsonism, Gait Disorders and Tremor
To study the adverse effects of trimetazidine on motor functions. A retrospective study was carried out using electronic records to identify all patients seen between January 1990 and August 2003. A neurological out-patient clinic. Of the 10 258 patients who attended the clinic, 130 received trimeta...
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| Veröffentlicht in: | Therapie 2005-07, Vol.60 (4), p.419-422 |
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| creator | Massó, José-Félix Martí Martí, Itxaso Carrera, Nieves Poza, Juan-José de Munain, Adolfo López |
| description | To study the adverse effects of trimetazidine on motor functions.
A retrospective study was carried out using electronic records to identify all patients seen between January 1990 and August 2003.
A neurological out-patient clinic.
Of the 10 258 patients who attended the clinic, 130 received trimetazidine. Treatment with this drug was discontinued in 128 patients. Of the 130 patients treated with trimetazidine, 29 also had other drugs capable of inducing parkinsonism withdrawn from their treatment.
Identification of an improvement in motor function after drug withdrawal.
In 56 of the 130 patients who were treated with trimetazidine (43%), an adverse effect on motor function was detected that had been induced or aggravated by one of the withdrawn drugs. Indeed, drug-induced parkinsonism was detected in 20 of these patients. Of these, ten were being treated with trimetazidine only, while the remaining ten were simultaneously receiving other drugs potentially capable of inducing parkinsonism. Treatment with trimetazidine worsened previously diagnosed Parkinson’s disease in 12 patients, and gait disorders coupled with disequilibrium was observed in 15 patients. Trimetazidine induced tremor in nine patients.
Trimetazidine can induce parkinsonism, gait disorder and tremor. These adverse effects have not been previously described for this drug.
Rapporter les effets indésirables moteurs induits par la trimétazidine.
Etude rétrospective des patients suivis en consultation de janvier 1990 à août 2003, dont les données ont été recueillies dans une base de données.
Cent trente sur 10 258 patients ont été mis sous trimétazidine. Le médicament a été supprimé chez 128 patients. D’autres médicaments pouvant provoquer un syndrome parkinsonien ont été suspendus chez 29 patients.
Evaluer l’amélioration clinique au niveau moteur après la suppression des médicaments.
Cinquante-six des 130 patients qui étaient sous trimétazidine ont développé un effet indésirable moteur déclenché ou aggravé par un des médicaments supprimés. Vingt patients ont développé un syndrome parkinsonien, dix en prenant uniquement de la trimétazidine, les dix restants prenaient aussi d’autres médicaments pouvant induire un syndrome parkinsonien. Par ailleurs, la trimétazidine a agravé un tableau parkinsonien déjà présent chez 12 patients, ainsi que des troubles de la marche et de l’équilibre chez 15 patients. Finalement, la trimétazidine a provoqué des tremblements chez neuf patients.
La trimétazidine peu |
| doi_str_mv | 10.2515/therapie:2005061 |
| format | Article |
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A retrospective study was carried out using electronic records to identify all patients seen between January 1990 and August 2003.
A neurological out-patient clinic.
Of the 10 258 patients who attended the clinic, 130 received trimetazidine. Treatment with this drug was discontinued in 128 patients. Of the 130 patients treated with trimetazidine, 29 also had other drugs capable of inducing parkinsonism withdrawn from their treatment.
Identification of an improvement in motor function after drug withdrawal.
In 56 of the 130 patients who were treated with trimetazidine (43%), an adverse effect on motor function was detected that had been induced or aggravated by one of the withdrawn drugs. Indeed, drug-induced parkinsonism was detected in 20 of these patients. Of these, ten were being treated with trimetazidine only, while the remaining ten were simultaneously receiving other drugs potentially capable of inducing parkinsonism. Treatment with trimetazidine worsened previously diagnosed Parkinson’s disease in 12 patients, and gait disorders coupled with disequilibrium was observed in 15 patients. Trimetazidine induced tremor in nine patients.
Trimetazidine can induce parkinsonism, gait disorder and tremor. These adverse effects have not been previously described for this drug.
Rapporter les effets indésirables moteurs induits par la trimétazidine.
Etude rétrospective des patients suivis en consultation de janvier 1990 à août 2003, dont les données ont été recueillies dans une base de données.
Cent trente sur 10 258 patients ont été mis sous trimétazidine. Le médicament a été supprimé chez 128 patients. D’autres médicaments pouvant provoquer un syndrome parkinsonien ont été suspendus chez 29 patients.
Evaluer l’amélioration clinique au niveau moteur après la suppression des médicaments.
Cinquante-six des 130 patients qui étaient sous trimétazidine ont développé un effet indésirable moteur déclenché ou aggravé par un des médicaments supprimés. Vingt patients ont développé un syndrome parkinsonien, dix en prenant uniquement de la trimétazidine, les dix restants prenaient aussi d’autres médicaments pouvant induire un syndrome parkinsonien. Par ailleurs, la trimétazidine a agravé un tableau parkinsonien déjà présent chez 12 patients, ainsi que des troubles de la marche et de l’équilibre chez 15 patients. Finalement, la trimétazidine a provoqué des tremblements chez neuf patients.
La trimétazidine peut provoquer un tableau parkinsonien, des troubles de la marche et des tremblements. Ces effets indésirables n’ont pas été antérieurement rapportés.</description><identifier>ISSN: 0040-5957</identifier><identifier>DOI: 10.2515/therapie:2005061</identifier><identifier>PMID: 16268443</identifier><identifier>CODEN: THERAP</identifier><language>eng</language><publisher>Eastleigh: Elsevier Masson SAS</publisher><subject>Adolescent ; Adult ; adverse effects ; Aged ; Aged, 80 and over ; Ambulatory Care Facilities ; Biological and medical sciences ; Drug toxicity and drugs side effects treatment ; drug-induced parkinsonism ; effets indésirables ; Female ; Gait Disorders, Neurologic - chemically induced ; Humans ; Male ; Medical sciences ; Middle Aged ; Nervous system (semeiology, syndromes) ; Nervous system as a whole ; Neurology ; Parkinson Disease - complications ; Parkinson Disease, Secondary - chemically induced ; parkinsonism ; parkinsonisme ; Pharmacology. Drug treatments ; Retrospective Studies ; Toxicity: nervous system and muscle ; Treatment Outcome ; Tremor - chemically induced ; trimetazidine ; Trimetazidine - adverse effects ; trimétazidine ; Vasodilator Agents - adverse effects</subject><ispartof>Therapie, 2005-07, Vol.60 (4), p.419-422</ispartof><rights>2005 Société Française de Pharmacologie et de Thérapeutique. Publié par Elsevier Masson SAS</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-a372188fe0c4b3a9c7c4e00ee5f9a6bb7303248c7072428b31c95e38b4612a793</citedby><cites>FETCH-LOGICAL-c447t-a372188fe0c4b3a9c7c4e00ee5f9a6bb7303248c7072428b31c95e38b4612a793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17270542$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16268443$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Massó, José-Félix Martí</creatorcontrib><creatorcontrib>Martí, Itxaso</creatorcontrib><creatorcontrib>Carrera, Nieves</creatorcontrib><creatorcontrib>Poza, Juan-José</creatorcontrib><creatorcontrib>de Munain, Adolfo López</creatorcontrib><title>Trimetazidine Induces Parkinsonism, Gait Disorders and Tremor</title><title>Therapie</title><addtitle>Therapie</addtitle><description>To study the adverse effects of trimetazidine on motor functions.
A retrospective study was carried out using electronic records to identify all patients seen between January 1990 and August 2003.
A neurological out-patient clinic.
Of the 10 258 patients who attended the clinic, 130 received trimetazidine. Treatment with this drug was discontinued in 128 patients. Of the 130 patients treated with trimetazidine, 29 also had other drugs capable of inducing parkinsonism withdrawn from their treatment.
Identification of an improvement in motor function after drug withdrawal.
In 56 of the 130 patients who were treated with trimetazidine (43%), an adverse effect on motor function was detected that had been induced or aggravated by one of the withdrawn drugs. Indeed, drug-induced parkinsonism was detected in 20 of these patients. Of these, ten were being treated with trimetazidine only, while the remaining ten were simultaneously receiving other drugs potentially capable of inducing parkinsonism. Treatment with trimetazidine worsened previously diagnosed Parkinson’s disease in 12 patients, and gait disorders coupled with disequilibrium was observed in 15 patients. Trimetazidine induced tremor in nine patients.
Trimetazidine can induce parkinsonism, gait disorder and tremor. These adverse effects have not been previously described for this drug.
Rapporter les effets indésirables moteurs induits par la trimétazidine.
Etude rétrospective des patients suivis en consultation de janvier 1990 à août 2003, dont les données ont été recueillies dans une base de données.
Cent trente sur 10 258 patients ont été mis sous trimétazidine. Le médicament a été supprimé chez 128 patients. D’autres médicaments pouvant provoquer un syndrome parkinsonien ont été suspendus chez 29 patients.
Evaluer l’amélioration clinique au niveau moteur après la suppression des médicaments.
Cinquante-six des 130 patients qui étaient sous trimétazidine ont développé un effet indésirable moteur déclenché ou aggravé par un des médicaments supprimés. Vingt patients ont développé un syndrome parkinsonien, dix en prenant uniquement de la trimétazidine, les dix restants prenaient aussi d’autres médicaments pouvant induire un syndrome parkinsonien. Par ailleurs, la trimétazidine a agravé un tableau parkinsonien déjà présent chez 12 patients, ainsi que des troubles de la marche et de l’équilibre chez 15 patients. Finalement, la trimétazidine a provoqué des tremblements chez neuf patients.
La trimétazidine peut provoquer un tableau parkinsonien, des troubles de la marche et des tremblements. Ces effets indésirables n’ont pas été antérieurement rapportés.</description><subject>Adolescent</subject><subject>Adult</subject><subject>adverse effects</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Ambulatory Care Facilities</subject><subject>Biological and medical sciences</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>drug-induced parkinsonism</subject><subject>effets indésirables</subject><subject>Female</subject><subject>Gait Disorders, Neurologic - chemically induced</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Nervous system as a whole</subject><subject>Neurology</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson Disease, Secondary - chemically induced</subject><subject>parkinsonism</subject><subject>parkinsonisme</subject><subject>Pharmacology. Drug treatments</subject><subject>Retrospective Studies</subject><subject>Toxicity: nervous system and muscle</subject><subject>Treatment Outcome</subject><subject>Tremor - chemically induced</subject><subject>trimetazidine</subject><subject>Trimetazidine - adverse effects</subject><subject>trimétazidine</subject><subject>Vasodilator Agents - adverse effects</subject><issn>0040-5957</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1P3EAQhrcgAgLpqZAbUmEy--W1T0qBDjiQTgFFF6VcrddjseFsHzt2BPx6jM6BKtUU87yvZh7GjjicCc31t_4eo9sEnAkADRnfYfsAClJdaLPHPhP9ARDcFGaX7fFMZLlScp99X8XQYO9eQhVaTG7aavBIyZ2LD6Glrg3UnCYLF_rkIlAXK4yUuLZKVhGbLh6yT7VbE36Z5gH7dXW5ml-ny9vFzfx8mXqlTJ86aQTP8xrBq1K6whuvEABR14XLytJIkELl3oARSuSl5L7QKPNSZVw4U8gD9nXbu4nd44DU2yaQx_XatdgNZAUUwohMjiBsQR87ooi13Yz_ufhsOdg3TfafJjtpGiPHU_dQNlh9BCZHI3AyAY68W9fRtT7QB2eEAa3EyKVbLlCPT-_70aTNjDTa5vDbrhbzn-OdP-xb72zL42jub8BoyQdsPVYhou9t1YX_X_0KO9GWDg</recordid><startdate>20050701</startdate><enddate>20050701</enddate><creator>Massó, José-Félix Martí</creator><creator>Martí, Itxaso</creator><creator>Carrera, Nieves</creator><creator>Poza, Juan-José</creator><creator>de Munain, Adolfo López</creator><general>Elsevier Masson SAS</general><general>EDP Sciences</general><general>Libbey</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20050701</creationdate><title>Trimetazidine Induces Parkinsonism, Gait Disorders and Tremor</title><author>Massó, José-Félix Martí ; Martí, Itxaso ; Carrera, Nieves ; Poza, Juan-José ; de Munain, Adolfo López</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-a372188fe0c4b3a9c7c4e00ee5f9a6bb7303248c7072428b31c95e38b4612a793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>adverse effects</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Ambulatory Care Facilities</topic><topic>Biological and medical sciences</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>drug-induced parkinsonism</topic><topic>effets indésirables</topic><topic>Female</topic><topic>Gait Disorders, Neurologic - chemically induced</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Nervous system as a whole</topic><topic>Neurology</topic><topic>Parkinson Disease - complications</topic><topic>Parkinson Disease, Secondary - chemically induced</topic><topic>parkinsonism</topic><topic>parkinsonisme</topic><topic>Pharmacology. Drug treatments</topic><topic>Retrospective Studies</topic><topic>Toxicity: nervous system and muscle</topic><topic>Treatment Outcome</topic><topic>Tremor - chemically induced</topic><topic>trimetazidine</topic><topic>Trimetazidine - adverse effects</topic><topic>trimétazidine</topic><topic>Vasodilator Agents - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Massó, José-Félix Martí</creatorcontrib><creatorcontrib>Martí, Itxaso</creatorcontrib><creatorcontrib>Carrera, Nieves</creatorcontrib><creatorcontrib>Poza, Juan-José</creatorcontrib><creatorcontrib>de Munain, Adolfo López</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Therapie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Massó, José-Félix Martí</au><au>Martí, Itxaso</au><au>Carrera, Nieves</au><au>Poza, Juan-José</au><au>de Munain, Adolfo López</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trimetazidine Induces Parkinsonism, Gait Disorders and Tremor</atitle><jtitle>Therapie</jtitle><addtitle>Therapie</addtitle><date>2005-07-01</date><risdate>2005</risdate><volume>60</volume><issue>4</issue><spage>419</spage><epage>422</epage><pages>419-422</pages><issn>0040-5957</issn><coden>THERAP</coden><abstract>To study the adverse effects of trimetazidine on motor functions.
A retrospective study was carried out using electronic records to identify all patients seen between January 1990 and August 2003.
A neurological out-patient clinic.
Of the 10 258 patients who attended the clinic, 130 received trimetazidine. Treatment with this drug was discontinued in 128 patients. Of the 130 patients treated with trimetazidine, 29 also had other drugs capable of inducing parkinsonism withdrawn from their treatment.
Identification of an improvement in motor function after drug withdrawal.
In 56 of the 130 patients who were treated with trimetazidine (43%), an adverse effect on motor function was detected that had been induced or aggravated by one of the withdrawn drugs. Indeed, drug-induced parkinsonism was detected in 20 of these patients. Of these, ten were being treated with trimetazidine only, while the remaining ten were simultaneously receiving other drugs potentially capable of inducing parkinsonism. Treatment with trimetazidine worsened previously diagnosed Parkinson’s disease in 12 patients, and gait disorders coupled with disequilibrium was observed in 15 patients. Trimetazidine induced tremor in nine patients.
Trimetazidine can induce parkinsonism, gait disorder and tremor. These adverse effects have not been previously described for this drug.
Rapporter les effets indésirables moteurs induits par la trimétazidine.
Etude rétrospective des patients suivis en consultation de janvier 1990 à août 2003, dont les données ont été recueillies dans une base de données.
Cent trente sur 10 258 patients ont été mis sous trimétazidine. Le médicament a été supprimé chez 128 patients. D’autres médicaments pouvant provoquer un syndrome parkinsonien ont été suspendus chez 29 patients.
Evaluer l’amélioration clinique au niveau moteur après la suppression des médicaments.
Cinquante-six des 130 patients qui étaient sous trimétazidine ont développé un effet indésirable moteur déclenché ou aggravé par un des médicaments supprimés. Vingt patients ont développé un syndrome parkinsonien, dix en prenant uniquement de la trimétazidine, les dix restants prenaient aussi d’autres médicaments pouvant induire un syndrome parkinsonien. Par ailleurs, la trimétazidine a agravé un tableau parkinsonien déjà présent chez 12 patients, ainsi que des troubles de la marche et de l’équilibre chez 15 patients. Finalement, la trimétazidine a provoqué des tremblements chez neuf patients.
La trimétazidine peut provoquer un tableau parkinsonien, des troubles de la marche et des tremblements. Ces effets indésirables n’ont pas été antérieurement rapportés.</abstract><cop>Eastleigh</cop><pub>Elsevier Masson SAS</pub><pmid>16268443</pmid><doi>10.2515/therapie:2005061</doi><tpages>4</tpages></addata></record> |
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| ispartof | Therapie, 2005-07, Vol.60 (4), p.419-422 |
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| subjects | Adolescent Adult adverse effects Aged Aged, 80 and over Ambulatory Care Facilities Biological and medical sciences Drug toxicity and drugs side effects treatment drug-induced parkinsonism effets indésirables Female Gait Disorders, Neurologic - chemically induced Humans Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Parkinson Disease - complications Parkinson Disease, Secondary - chemically induced parkinsonism parkinsonisme Pharmacology. Drug treatments Retrospective Studies Toxicity: nervous system and muscle Treatment Outcome Tremor - chemically induced trimetazidine Trimetazidine - adverse effects trimétazidine Vasodilator Agents - adverse effects |
| title | Trimetazidine Induces Parkinsonism, Gait Disorders and Tremor |
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