Rescue haploidentical peripheral blood stem cell transplantation for engraftment failure: a single‐centre case series
Graft failure affects approximately 5% of allogeneic stem cell transplants, with a poor prognosis. Salvage second allogeneic stem cell transplantation (alloSCT2) is limited by high rates of transplant‐related mortality from infection and graft‐versus‐host disease. We report on five adult patients re...
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| Veröffentlicht in: | Internal medicine journal 2018-08, Vol.48 (8), p.988-991 |
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| container_title | Internal medicine journal |
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| creator | Kliman, David Bilmon, Ian Kwan, John Blyth, Emily Micklethwaite, Ken Panicker, Shyam Bhattacharyya, Abir Deren, Stephanie Antonenas, Vicki Huang, Gillian Gottlieb, David |
| description | Graft failure affects approximately 5% of allogeneic stem cell transplants, with a poor prognosis. Salvage second allogeneic stem cell transplantation (alloSCT2) is limited by high rates of transplant‐related mortality from infection and graft‐versus‐host disease. We report on five adult patients receiving rescue alloSCT2 using haploidentical peripheral blood stem cells. All patients achieved neutrophil engraftment, two subsequently died from sepsis and disease relapse, respectively. Three patients remain alive up to 2 years post‐transplant. We suggest consideration of haploidentical alloSCT2 for patients with graft failure. |
| doi_str_mv | 10.1111/imj.13979 |
| format | Article |
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Salvage second allogeneic stem cell transplantation (alloSCT2) is limited by high rates of transplant‐related mortality from infection and graft‐versus‐host disease. We report on five adult patients receiving rescue alloSCT2 using haploidentical peripheral blood stem cells. All patients achieved neutrophil engraftment, two subsequently died from sepsis and disease relapse, respectively. Three patients remain alive up to 2 years post‐transplant. We suggest consideration of haploidentical alloSCT2 for patients with graft failure.</description><identifier>ISSN: 1444-0903</identifier><identifier>EISSN: 1445-5994</identifier><identifier>DOI: 10.1111/imj.13979</identifier><identifier>PMID: 30133987</identifier><language>eng</language><publisher>Melbourne: John Wiley & Sons Australia, Ltd</publisher><subject>Adult ; allogeneic stem cell transplant ; Female ; graft failure ; Graft rejection ; Graft Rejection - diagnosis ; Graft Rejection - therapy ; Graft Survival - physiology ; Grafts ; graft‐versus‐host disease ; haploidentical transplant ; Hematopoietic stem cells ; Humans ; Male ; Middle Aged ; Peripheral blood ; Peripheral Blood Stem Cell Transplantation - methods ; Peripheral Blood Stem Cell Transplantation - trends ; peripheral blood stem cells ; Salvage Therapy - methods ; Salvage Therapy - trends ; Sepsis ; Stem cell transplantation ; Stem cells ; Transplantation, Haploidentical - methods ; Transplantation, Haploidentical - trends ; Transplants & implants ; Treatment Failure ; Young Adult</subject><ispartof>Internal medicine journal, 2018-08, Vol.48 (8), p.988-991</ispartof><rights>2018 Royal Australasian College of Physicians</rights><rights>2018 Royal Australasian College of Physicians.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2439-a714983975fe1868add9fedcba25b0aa115e3f423585707b76bab3d74868d30b3</cites><orcidid>0000-0002-2020-0275</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fimj.13979$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fimj.13979$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30133987$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kliman, David</creatorcontrib><creatorcontrib>Bilmon, Ian</creatorcontrib><creatorcontrib>Kwan, John</creatorcontrib><creatorcontrib>Blyth, Emily</creatorcontrib><creatorcontrib>Micklethwaite, Ken</creatorcontrib><creatorcontrib>Panicker, Shyam</creatorcontrib><creatorcontrib>Bhattacharyya, Abir</creatorcontrib><creatorcontrib>Deren, Stephanie</creatorcontrib><creatorcontrib>Antonenas, Vicki</creatorcontrib><creatorcontrib>Huang, Gillian</creatorcontrib><creatorcontrib>Gottlieb, David</creatorcontrib><title>Rescue haploidentical peripheral blood stem cell transplantation for engraftment failure: a single‐centre case series</title><title>Internal medicine journal</title><addtitle>Intern Med J</addtitle><description>Graft failure affects approximately 5% of allogeneic stem cell transplants, with a poor prognosis. Salvage second allogeneic stem cell transplantation (alloSCT2) is limited by high rates of transplant‐related mortality from infection and graft‐versus‐host disease. We report on five adult patients receiving rescue alloSCT2 using haploidentical peripheral blood stem cells. All patients achieved neutrophil engraftment, two subsequently died from sepsis and disease relapse, respectively. Three patients remain alive up to 2 years post‐transplant. We suggest consideration of haploidentical alloSCT2 for patients with graft failure.</description><subject>Adult</subject><subject>allogeneic stem cell transplant</subject><subject>Female</subject><subject>graft failure</subject><subject>Graft rejection</subject><subject>Graft Rejection - diagnosis</subject><subject>Graft Rejection - therapy</subject><subject>Graft Survival - physiology</subject><subject>Grafts</subject><subject>graft‐versus‐host disease</subject><subject>haploidentical transplant</subject><subject>Hematopoietic stem cells</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Peripheral blood</subject><subject>Peripheral Blood Stem Cell Transplantation - methods</subject><subject>Peripheral Blood Stem Cell Transplantation - trends</subject><subject>peripheral blood stem cells</subject><subject>Salvage Therapy - methods</subject><subject>Salvage Therapy - trends</subject><subject>Sepsis</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Transplantation, Haploidentical - methods</subject><subject>Transplantation, Haploidentical - trends</subject><subject>Transplants & implants</subject><subject>Treatment Failure</subject><subject>Young Adult</subject><issn>1444-0903</issn><issn>1445-5994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctKxTAQhoMo3he-gATc6KKepElPGnciXo4ogui6TNup5pA2NWkRdz6Cz-iTGD3qQjCbGciXj8z8hOxwdsjjmZh2fsiFVnqJrHMpsyTTWi5_9TJhmok1shHCnDGuhJarZE0wLoTO1Tp5vsVQjUgfobfO1NgNpgJLe_Smf0Qf29I6V9MwYEsrtJYOHrrQW-gGGIzraOM8xe7BQzO08TltwNjR4xEFGkz3YPH99a2KFx5pBQFpiGoMW2SlARtw-7tukvuz07uTi-Tq5nx2cnyVVKkUOgHFpc7jaFmDPJ_mUNe6wboqIc1KBsB5hqKRqcjyTDFVqmkJpaiVjGwtWCk2yf7C23v3NGIYitaEzzmgQzeGImU6zYRSqY7o3h907kbfxd9FKpfTlKmcR-pgQVXeheCxKXpvWvAvBWfFZxpFTKP4SiOyu9_GsWyx_iV_1h-ByQJ4NhZf_jcVs-vLhfIDuAmWOg</recordid><startdate>201808</startdate><enddate>201808</enddate><creator>Kliman, David</creator><creator>Bilmon, Ian</creator><creator>Kwan, John</creator><creator>Blyth, Emily</creator><creator>Micklethwaite, Ken</creator><creator>Panicker, Shyam</creator><creator>Bhattacharyya, Abir</creator><creator>Deren, Stephanie</creator><creator>Antonenas, Vicki</creator><creator>Huang, Gillian</creator><creator>Gottlieb, David</creator><general>John Wiley & Sons Australia, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2020-0275</orcidid></search><sort><creationdate>201808</creationdate><title>Rescue haploidentical peripheral blood stem cell transplantation for engraftment failure: a single‐centre case series</title><author>Kliman, David ; Bilmon, Ian ; Kwan, John ; Blyth, Emily ; Micklethwaite, Ken ; Panicker, Shyam ; Bhattacharyya, Abir ; Deren, Stephanie ; Antonenas, Vicki ; Huang, Gillian ; Gottlieb, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2439-a714983975fe1868add9fedcba25b0aa115e3f423585707b76bab3d74868d30b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>allogeneic stem cell transplant</topic><topic>Female</topic><topic>graft failure</topic><topic>Graft rejection</topic><topic>Graft Rejection - diagnosis</topic><topic>Graft Rejection - therapy</topic><topic>Graft Survival - physiology</topic><topic>Grafts</topic><topic>graft‐versus‐host disease</topic><topic>haploidentical transplant</topic><topic>Hematopoietic stem cells</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Peripheral blood</topic><topic>Peripheral Blood Stem Cell Transplantation - methods</topic><topic>Peripheral Blood Stem Cell Transplantation - trends</topic><topic>peripheral blood stem cells</topic><topic>Salvage Therapy - methods</topic><topic>Salvage Therapy - trends</topic><topic>Sepsis</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Transplantation, Haploidentical - methods</topic><topic>Transplantation, Haploidentical - trends</topic><topic>Transplants & implants</topic><topic>Treatment Failure</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kliman, David</creatorcontrib><creatorcontrib>Bilmon, Ian</creatorcontrib><creatorcontrib>Kwan, John</creatorcontrib><creatorcontrib>Blyth, Emily</creatorcontrib><creatorcontrib>Micklethwaite, Ken</creatorcontrib><creatorcontrib>Panicker, Shyam</creatorcontrib><creatorcontrib>Bhattacharyya, Abir</creatorcontrib><creatorcontrib>Deren, Stephanie</creatorcontrib><creatorcontrib>Antonenas, Vicki</creatorcontrib><creatorcontrib>Huang, Gillian</creatorcontrib><creatorcontrib>Gottlieb, David</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Internal medicine journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kliman, David</au><au>Bilmon, Ian</au><au>Kwan, John</au><au>Blyth, Emily</au><au>Micklethwaite, Ken</au><au>Panicker, Shyam</au><au>Bhattacharyya, Abir</au><au>Deren, Stephanie</au><au>Antonenas, Vicki</au><au>Huang, Gillian</au><au>Gottlieb, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rescue haploidentical peripheral blood stem cell transplantation for engraftment failure: a single‐centre case series</atitle><jtitle>Internal medicine journal</jtitle><addtitle>Intern Med J</addtitle><date>2018-08</date><risdate>2018</risdate><volume>48</volume><issue>8</issue><spage>988</spage><epage>991</epage><pages>988-991</pages><issn>1444-0903</issn><eissn>1445-5994</eissn><abstract>Graft failure affects approximately 5% of allogeneic stem cell transplants, with a poor prognosis. Salvage second allogeneic stem cell transplantation (alloSCT2) is limited by high rates of transplant‐related mortality from infection and graft‐versus‐host disease. We report on five adult patients receiving rescue alloSCT2 using haploidentical peripheral blood stem cells. All patients achieved neutrophil engraftment, two subsequently died from sepsis and disease relapse, respectively. Three patients remain alive up to 2 years post‐transplant. We suggest consideration of haploidentical alloSCT2 for patients with graft failure.</abstract><cop>Melbourne</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>30133987</pmid><doi>10.1111/imj.13979</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-2020-0275</orcidid></addata></record> |
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| ispartof | Internal medicine journal, 2018-08, Vol.48 (8), p.988-991 |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Adult allogeneic stem cell transplant Female graft failure Graft rejection Graft Rejection - diagnosis Graft Rejection - therapy Graft Survival - physiology Grafts graft‐versus‐host disease haploidentical transplant Hematopoietic stem cells Humans Male Middle Aged Peripheral blood Peripheral Blood Stem Cell Transplantation - methods Peripheral Blood Stem Cell Transplantation - trends peripheral blood stem cells Salvage Therapy - methods Salvage Therapy - trends Sepsis Stem cell transplantation Stem cells Transplantation, Haploidentical - methods Transplantation, Haploidentical - trends Transplants & implants Treatment Failure Young Adult |
| title | Rescue haploidentical peripheral blood stem cell transplantation for engraftment failure: a single‐centre case series |
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