The Prognostic Value of Cancer Stem Cell Markers (Notch1, ALDH1, and CD44) in Primary Colorectal Carcinoma

Background Cancer stem cells proved to have a vital role in cell migration, invasion, metastasis, and treatment resistance of colorectal cancer (CRC) that subsequently lead to poor clinical outcomes. These stem cells may be a novel therapeutic target for the management of CRC progression. Signals of...

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Veröffentlicht in:	Journal of gastrointestinal cancer 2019-12, Vol.50 (4), p.824-837
Hauptverfasser:	Mohamed, Salem Y., Kaf, Randa Mohamed, Ahmed, Mona Mostafa, Elwan, Amira, Ashour, Hassan R, Ibrahim, Amr
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aldehyde Dehydrogenase 1 - analysis Aldehyde Dehydrogenase 1 - metabolism Biomarkers, Tumor - analysis Biomarkers, Tumor - metabolism Cancer Research Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Disease-Free Survival Epithelial-Mesenchymal Transition Female Follow-Up Studies Gastroenterology Humans Hyaluronan Receptors - analysis Hyaluronan Receptors - metabolism Immunohistochemistry Internal Medicine Kaplan-Meier Estimate Lymphatic Metastasis - pathology Male Medicine Medicine & Public Health Middle Aged Neoplasm Recurrence, Local - diagnosis Neoplasm Recurrence, Local - pathology Neoplasm Staging Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Oncology Original Research Prognosis Radiotherapy Receptor, Notch1 - analysis Receptor, Notch1 - metabolism Retrospective Studies Tumor Burden
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