Ultra-pH-responsive split i-motif based aptamer anchoring strategy for specific activatable imaging of acidic tumor microenvironment

Ultra-pH-responsive split i-motif based aptamer anchoring strategy for specific activatable imaging of acidic tumor microenvironment

A non-blocking split i-motif based aptamer anchoring strategy was developed as a general platform for sensing weakly acidic tumor microenvironment. By rationally tuning the response range to pH 7.0-6.4 and adjusting aptamer types, the strategy achieved specific, pH e -activated imaging of different...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2018, Vol.54 (73), p.1288-1291
Hauptverfasser: Lei, Yanli, He, Xiaoxiao, Tang, Jinlu, Shi, Hui, He, Dinggeng, Yan, Lv'an, Liu, Jianbo, Zeng, Yu, Wang, Kemin
Format: Artikel
Sprache:eng
Schlagworte:
Anchoring
Strategy
Tumors
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Zusammenfassung:A non-blocking split i-motif based aptamer anchoring strategy was developed as a general platform for sensing weakly acidic tumor microenvironment. By rationally tuning the response range to pH 7.0-6.4 and adjusting aptamer types, the strategy achieved specific, pH e -activated imaging of different cancers in vitro and in vivo . Non-blocking split i-motif based aptamer anchoring strategy was developed as a general platform for sensing weakly acidic tumor microenvironment.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc04420a