Contaminant-associated disruption of vitamin A and its receptor (retinoic acid receptor α) in free-ranging harbour seals ( Phoca vitulina)

Polychlorinated biphenyls (PCBs) have been associated with a number of toxic effects in marine mammals such as endocrine disruption and immunotoxicity that, in turn, are widely thought to have contributed to population level impacts including reproductive failure and outbreaks of disease. In this st...

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Veröffentlicht in:	Aquatic toxicology 2007-03, Vol.81 (3), p.319-328
Hauptverfasser:	Mos, L., Tabuchi, M., Dangerfield, N., Jeffries, S.J., Koop, B.F., Ross, P.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - chemistry Animal, plant and microbial ecology Animals Applied ecology Base Sequence Biological and medical sciences Biomarker biomarkers Biomarkers - analysis blood plasma blubber body fat DNA Primers - chemistry Ecotoxicology, biological effects of pollution Endocrine disruption Female Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Gene Expression Profiling - veterinary General aspects Harbour seal Male Mammalia Marine Molecular Sequence Data PCBs Phoca - physiology Phoca vitulina physiological response polychlorinated biphenyls Polychlorinated Biphenyls - analysis Polychlorinated Biphenyls - toxicity receptors Receptors, Retinoic Acid - analysis Receptors, Retinoic Acid - drug effects Receptors, Retinoic Acid - genetics retinoic acid Retinoic acid receptor Retinoic Acid Receptor alpha retinoic acid receptor α Retinol Reverse Transcriptase Polymerase Chain Reaction seals skin Skin - chemistry Statistics as Topic Vertebrates: general zoology, morphology, phylogeny, systematics, cytogenetics, geographical distribution vitamin A Vitamin A - analysis Water Pollutants, Chemical - toxicity water pollution
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