Mechanisms of thrombocytopenia induced by interferon therapy for chronic hepatitis B

To clarify the mechanisms of thrombocytopenia observed in patients with chronic hepatitis B treated with interferon. We studied six patients with chronic active hepatitis B who received intramuscular injections of natural interferon-alpha (3 or 5 million IU/ day) for 4 weeks. Peripheral blood platel...

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Veröffentlicht in:	Journal of gastroenterology 1997-03, Vol.32 (2), p.206-210
Hauptverfasser:	Sata, M, Yano, Y, Yoshiyama, Y, Ide, T, Kumashiro, R, Suzuki, H, Tanikawa, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antiviral Agents - adverse effects Antiviral Agents - therapeutic use Blood Platelets - physiology Bone marrow Cell differentiation Cell proliferation Cell Survival Chronic active hepatitis Female Hematopoietic Stem Cells - cytology Hepatitis B Hepatitis B - therapy Hepatitis, Chronic - therapy Humans Interferon Interferon-alpha - adverse effects Interferon-alpha - therapeutic use Male Megakaryocytes Middle Aged Peripheral blood Platelet Count Platelets Thrombocytopenia Thrombocytopenia - etiology Time Factors α-Interferon
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