Disturbances in social interaction occur along with pathophysiological deficits following sub-chronic phencyclidine administration in the rat
A sub-chronic administration of phencyclidine to the rat brings about enduring pathophysiological and cognitive changes that resemble some features of schizophrenia. The present study aimed to determine whether the behavioural consequence of this phencyclidine regime extends to a long-term disruptio...
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| Veröffentlicht in: | Behavioural brain research 2008-12, Vol.194 (2), p.230-235 |
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| creator | Jenkins, Trisha A. Harte, Michael K. McKibben, Claire E. Elliott, Jennifer J. Reynolds, Gavin P. |
| description | A sub-chronic administration of phencyclidine to the rat brings about enduring pathophysiological and cognitive changes that resemble some features of schizophrenia. The present study aimed to determine whether the behavioural consequence of this phencyclidine regime extends to a long-term disruption of social interaction that might provide a parallel with some negative symptoms of the disease. Rats were treated with phencyclidine (2
mg/kg bi-daily for 1 week) or vehicle followed by a drug-free period. Social interaction was assessed 24
h, 1 week, 3 weeks and 6 weeks post-treatment. A long-lasting disturbance of social behaviour was observed in the phencyclidine group, namely more contact and non-contact interaction with an unfamiliar target rat at all time points. Six weeks post-phencyclidine, analysis of brains showed a reduction in expression of parvalbumin immunoreactive neurons in the hippocampus with significant reductions localised to the CA1 and dentate gyrus regions. These results show that sub-chronic phencyclidine produces long-lasting disruptions in social interaction that, however, do not model the social withdrawal seen in patients with schizophrenia. These disturbances of social behaviour may be associated with concurrent pathophysiological brain changes. |
| doi_str_mv | 10.1016/j.bbr.2008.07.020 |
| format | Article |
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mg/kg bi-daily for 1 week) or vehicle followed by a drug-free period. Social interaction was assessed 24
h, 1 week, 3 weeks and 6 weeks post-treatment. A long-lasting disturbance of social behaviour was observed in the phencyclidine group, namely more contact and non-contact interaction with an unfamiliar target rat at all time points. Six weeks post-phencyclidine, analysis of brains showed a reduction in expression of parvalbumin immunoreactive neurons in the hippocampus with significant reductions localised to the CA1 and dentate gyrus regions. These results show that sub-chronic phencyclidine produces long-lasting disruptions in social interaction that, however, do not model the social withdrawal seen in patients with schizophrenia. These disturbances of social behaviour may be associated with concurrent pathophysiological brain changes.</description><subject>Adult and adolescent clinical studies</subject><subject>Analysis of Variance</subject><subject>Animal model</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Disease Models, Animal</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GABAergic</subject><subject>Hallucinogens - administration & dosage</subject><subject>Hippocampus</subject><subject>Hippocampus - metabolism</subject><subject>Interpersonal Relations</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Motor Activity - drug effects</subject><subject>Parvalbumin</subject><subject>Parvalbumins - metabolism</subject><subject>Phencyclidine - administration & dosage</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Rats</subject><subject>Schizophrenia</subject><subject>Schizophrenia - chemically induced</subject><subject>Schizophrenia - pathology</subject><subject>Schizophrenia - physiopathology</subject><subject>Social interaction</subject><subject>Time Factors</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAQhi0EotvCA3BBvsAtwXYSJxYn1EJBqsSld8txJs2ssnGwHap9CN6ZKbuCGyePR9_8M_p_xt5IUUoh9Yd92fexVEJ0pWhLocQztpNdq4q2qc1ztiNGF3Wlugt2mdJeCFGLRr5kFwQJXTdyx37dYMpb7N3iIXFceAoe3UxVhuh8xrDw4P0WuZvD8sAfMU98dXkK63RMGObwgJ74AUb0mBMfwzyHRyQ0bX3hpxgW9HydYPFHP-OAC3A3HHChvdH90aeteQJOv1fsxejmBK_P7xW7__L5_vprcff99tv1p7vC11LlQoLpqkaDF50wzledNq0B6XRjRjD1ICsj66YbRl3pplamUoOhnnGghVKuumLvT7JrDD82SNkeMHmYZ7dA2JJVwijZ6opAeQJ9DClFGO0a8eDi0UphnyKwe0sR2KcIrGgtRUAzb8_iW3-A4d_E2XMC3p0Bl8i6MZL3mP5ySui2rpqOuI8nDsiJnwjRJo9kIwwYwWc7BPzPGb8B8_6mlw</recordid><startdate>20081212</startdate><enddate>20081212</enddate><creator>Jenkins, Trisha A.</creator><creator>Harte, Michael K.</creator><creator>McKibben, Claire E.</creator><creator>Elliott, Jennifer J.</creator><creator>Reynolds, Gavin P.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope></search><sort><creationdate>20081212</creationdate><title>Disturbances in social interaction occur along with pathophysiological deficits following sub-chronic phencyclidine administration in the rat</title><author>Jenkins, Trisha A. ; Harte, Michael K. ; McKibben, Claire E. ; Elliott, Jennifer J. ; Reynolds, Gavin P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-1e98356ec0809ac386979e1a659fe94d1391458df636542932d91399ae6022a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Analysis of Variance</topic><topic>Animal model</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Disease Models, Animal</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GABAergic</topic><topic>Hallucinogens - administration & dosage</topic><topic>Hippocampus</topic><topic>Hippocampus - metabolism</topic><topic>Interpersonal Relations</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Motor Activity - drug effects</topic><topic>Parvalbumin</topic><topic>Parvalbumins - metabolism</topic><topic>Phencyclidine - administration & dosage</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Rats</topic><topic>Schizophrenia</topic><topic>Schizophrenia - chemically induced</topic><topic>Schizophrenia - pathology</topic><topic>Schizophrenia - physiopathology</topic><topic>Social interaction</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jenkins, Trisha A.</creatorcontrib><creatorcontrib>Harte, Michael K.</creatorcontrib><creatorcontrib>McKibben, Claire E.</creatorcontrib><creatorcontrib>Elliott, Jennifer J.</creatorcontrib><creatorcontrib>Reynolds, Gavin P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jenkins, Trisha A.</au><au>Harte, Michael K.</au><au>McKibben, Claire E.</au><au>Elliott, Jennifer J.</au><au>Reynolds, Gavin P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disturbances in social interaction occur along with pathophysiological deficits following sub-chronic phencyclidine administration in the rat</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>2008-12-12</date><risdate>2008</risdate><volume>194</volume><issue>2</issue><spage>230</spage><epage>235</epage><pages>230-235</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><coden>BBREDI</coden><abstract>A sub-chronic administration of phencyclidine to the rat brings about enduring pathophysiological and cognitive changes that resemble some features of schizophrenia. The present study aimed to determine whether the behavioural consequence of this phencyclidine regime extends to a long-term disruption of social interaction that might provide a parallel with some negative symptoms of the disease. Rats were treated with phencyclidine (2
mg/kg bi-daily for 1 week) or vehicle followed by a drug-free period. Social interaction was assessed 24
h, 1 week, 3 weeks and 6 weeks post-treatment. A long-lasting disturbance of social behaviour was observed in the phencyclidine group, namely more contact and non-contact interaction with an unfamiliar target rat at all time points. Six weeks post-phencyclidine, analysis of brains showed a reduction in expression of parvalbumin immunoreactive neurons in the hippocampus with significant reductions localised to the CA1 and dentate gyrus regions. These results show that sub-chronic phencyclidine produces long-lasting disruptions in social interaction that, however, do not model the social withdrawal seen in patients with schizophrenia. These disturbances of social behaviour may be associated with concurrent pathophysiological brain changes.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>18706451</pmid><doi>10.1016/j.bbr.2008.07.020</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult and adolescent clinical studies Analysis of Variance Animal model Animals Behavior, Animal - drug effects Behavioral psychophysiology Biological and medical sciences Disease Models, Animal Fundamental and applied biological sciences. Psychology GABAergic Hallucinogens - administration & dosage Hippocampus Hippocampus - metabolism Interpersonal Relations Male Medical sciences Motor Activity - drug effects Parvalbumin Parvalbumins - metabolism Phencyclidine - administration & dosage Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Psychoses Rats Schizophrenia Schizophrenia - chemically induced Schizophrenia - pathology Schizophrenia - physiopathology Social interaction Time Factors |
| title | Disturbances in social interaction occur along with pathophysiological deficits following sub-chronic phencyclidine administration in the rat |
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