Altered Expression of Extracellular Matrix in Human-Cytomegalovirus-Infected Cells and a Human Artery Organ Culture Model to Study Its Biological Relevance

The influence of human cytomegalovirus (HCMV) on the transcription of 11 selected, representative extracellular matrix genes was investigated in cell culture. Northern blot hybridization indicated the downregulation of all mRNAs investigated. Based on our results and the known repression of other ex...

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Veröffentlicht in:	Intervirology 1999, Vol.42 (5-6), p.357-364
Hauptverfasser:	Schaarschmidt, Peter, Reinhardt, Barbara, Michel, Detlef, Vaida, Bianca, Mayr, Klaus, Lüske, Anke, Baur, Regine, Gschwend, Jürgen, Kleinschmidt, Klaus, Kountidis, Margaritis, Wenderoth, Ulrich, Voisard, Rainer, Mertens, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured Cytomegalovirus - physiology Cytomegalovirus Infections - metabolism Cytomegalovirus Infections - pathology Cytomegalovirus Infections - virology Cytopathogenic Effect, Viral extracellular matrix Extracellular Matrix - metabolism Extracellular Matrix Proteins - biosynthesis Extracellular Matrix Proteins - genetics Gene Expression Regulation Human cytomegalovirus Humans Models, Biological Organ Culture Techniques Part I. Immunopathology. CMV-Induced Pathomechanisms Renal Artery - metabolism Renal Artery - virology
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