The neutralizing capacity of Androctonus crassicauda antivenom against Mesobuthus eupeus scorpion venom
Scorpion envenomations are considerable health problem in tropical and subtropical regions. There are approximately 1500 species of scorpions worldwide. The number of dangerous species in the Buthidae family is significantly higher than in other families of scorpions. Mesobuthus eupeus is a member o...
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| Veröffentlicht in: | Toxicon (Oxford) 2008-08, Vol.52 (2), p.375-379 |
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| creator | Ozkan, Ozcan Carhan, Ahmet |
| description | Scorpion envenomations are considerable health problem in tropical and subtropical regions. There are approximately 1500 species of scorpions worldwide. The number of dangerous species in the Buthidae family is significantly higher than in other families of scorpions.
Mesobuthus eupeus is a member of
Mesobuthus genus, Buthidae family. In this study, the potency and para-specific activities of
Androctonus crassicauda antivenom were investigated against
M. eupeus scorpion venom.
The median lethal dose of
M. eupeus and
A. crassicauda scorpion venoms were found to be 0.18
mg/kg, 15.45
μg/kg by i.c.v injection route. The antivenom showed neutralization effect against the venoms of
M. eupeus. One milliliter of
A. crassicauda antivenom neutralizes 464LD
50 of
M. eupeus and 940LD
50
A. crassicauda venom on mice. Western blotting demonstrated immunologic reaction with the venoms. The monovalent antivenom has immunoactivity and neutralizing capacity to the scorpion venoms. This study indicates that the antivenom produced by Refik Saydam Hygiene Center could be used for the treatment of
M. eupeus stings in Turkey. |
| doi_str_mv | 10.1016/j.toxicon.2008.06.019 |
| format | Article |
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Mesobuthus eupeus is a member of
Mesobuthus genus, Buthidae family. In this study, the potency and para-specific activities of
Androctonus crassicauda antivenom were investigated against
M. eupeus scorpion venom.
The median lethal dose of
M. eupeus and
A. crassicauda scorpion venoms were found to be 0.18
mg/kg, 15.45
μg/kg by i.c.v injection route. The antivenom showed neutralization effect against the venoms of
M. eupeus. One milliliter of
A. crassicauda antivenom neutralizes 464LD
50 of
M. eupeus and 940LD
50
A. crassicauda venom on mice. Western blotting demonstrated immunologic reaction with the venoms. The monovalent antivenom has immunoactivity and neutralizing capacity to the scorpion venoms. This study indicates that the antivenom produced by Refik Saydam Hygiene Center could be used for the treatment of
M. eupeus stings in Turkey.</description><identifier>ISSN: 0041-0101</identifier><identifier>EISSN: 1879-3150</identifier><identifier>DOI: 10.1016/j.toxicon.2008.06.019</identifier><identifier>PMID: 18625264</identifier><identifier>CODEN: TOXIA6</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Androctonus crassicauda ; Androctonus crassicauda antivenom ; Animal poisons toxicology. Antivenoms ; Animals ; Antivenins - therapeutic use ; Biological and medical sciences ; Buthidae ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Lethal Dose 50 ; Medical sciences ; Mesobuthus eupeus ; Mice ; Neutralization Tests ; Para-specific activity ; Scorpion ; Scorpion Venoms - chemistry ; Scorpion Venoms - immunology ; Scorpion Venoms - toxicity ; Scorpions - physiology ; Species Specificity ; Toxicology ; Venom</subject><ispartof>Toxicon (Oxford), 2008-08, Vol.52 (2), p.375-379</ispartof><rights>2008 Elsevier Ltd</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-af1bfa8958859a866fec8a36378a09912d56662b3b4c0ae9c20a9838ae8126c83</citedby><cites>FETCH-LOGICAL-c424t-af1bfa8958859a866fec8a36378a09912d56662b3b4c0ae9c20a9838ae8126c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.toxicon.2008.06.019$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20664795$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18625264$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ozkan, Ozcan</creatorcontrib><creatorcontrib>Carhan, Ahmet</creatorcontrib><title>The neutralizing capacity of Androctonus crassicauda antivenom against Mesobuthus eupeus scorpion venom</title><title>Toxicon (Oxford)</title><addtitle>Toxicon</addtitle><description>Scorpion envenomations are considerable health problem in tropical and subtropical regions. There are approximately 1500 species of scorpions worldwide. The number of dangerous species in the Buthidae family is significantly higher than in other families of scorpions.
Mesobuthus eupeus is a member of
Mesobuthus genus, Buthidae family. In this study, the potency and para-specific activities of
Androctonus crassicauda antivenom were investigated against
M. eupeus scorpion venom.
The median lethal dose of
M. eupeus and
A. crassicauda scorpion venoms were found to be 0.18
mg/kg, 15.45
μg/kg by i.c.v injection route. The antivenom showed neutralization effect against the venoms of
M. eupeus. One milliliter of
A. crassicauda antivenom neutralizes 464LD
50 of
M. eupeus and 940LD
50
A. crassicauda venom on mice. Western blotting demonstrated immunologic reaction with the venoms. The monovalent antivenom has immunoactivity and neutralizing capacity to the scorpion venoms. This study indicates that the antivenom produced by Refik Saydam Hygiene Center could be used for the treatment of
M. eupeus stings in Turkey.</description><subject>Androctonus crassicauda</subject><subject>Androctonus crassicauda antivenom</subject><subject>Animal poisons toxicology. Antivenoms</subject><subject>Animals</subject><subject>Antivenins - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Buthidae</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Lethal Dose 50</subject><subject>Medical sciences</subject><subject>Mesobuthus eupeus</subject><subject>Mice</subject><subject>Neutralization Tests</subject><subject>Para-specific activity</subject><subject>Scorpion</subject><subject>Scorpion Venoms - chemistry</subject><subject>Scorpion Venoms - immunology</subject><subject>Scorpion Venoms - toxicity</subject><subject>Scorpions - physiology</subject><subject>Species Specificity</subject><subject>Toxicology</subject><subject>Venom</subject><issn>0041-0101</issn><issn>1879-3150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0MFu1DAQgGELgei25RFAucAt6dhJvPYJVRUUpFZc2rM1cSZbr7J2sJ2q5elJ2QiOnObyzdj6GXvPoeLA5cW-yuHJ2eArAaAqkBVw_YptuNrqsuYtvGYbgIaXsPATdprSHgBqpeVbdsKVFK2QzYbt7h6o8DTniKP75fyusDihdfm5CENx6fsYbA5-ToWNmJKzOPdYoM_ukXw4FLhD51MubimFbs4PC6R5omUkG-Lkgi_-wHP2ZsAx0bt1nrH7r1_urr6VNz-uv19d3pS2EU0uceDdgEq3SrUalZQDWYW1rLcKQWsu-lZKKbq6aywgaSsAtaoVkuJCWlWfsU_Hu1MMP2dK2RxcsjSO6CnMyQjQXDViu8D2CG0MKUUazBTdAeOz4WBeCpu9WQubl8IGpFkKL3sf1gfm7kD9v6016QI-rgCTxXGI6K1Lf50AKZutbhf3-ehoyfHoKJpkHXlLvYtks-mD-89XfgNfKZ7U</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>Ozkan, Ozcan</creator><creator>Carhan, Ahmet</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20080801</creationdate><title>The neutralizing capacity of Androctonus crassicauda antivenom against Mesobuthus eupeus scorpion venom</title><author>Ozkan, Ozcan ; Carhan, Ahmet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-af1bfa8958859a866fec8a36378a09912d56662b3b4c0ae9c20a9838ae8126c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Androctonus crassicauda</topic><topic>Androctonus crassicauda antivenom</topic><topic>Animal poisons toxicology. Antivenoms</topic><topic>Animals</topic><topic>Antivenins - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Buthidae</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Lethal Dose 50</topic><topic>Medical sciences</topic><topic>Mesobuthus eupeus</topic><topic>Mice</topic><topic>Neutralization Tests</topic><topic>Para-specific activity</topic><topic>Scorpion</topic><topic>Scorpion Venoms - chemistry</topic><topic>Scorpion Venoms - immunology</topic><topic>Scorpion Venoms - toxicity</topic><topic>Scorpions - physiology</topic><topic>Species Specificity</topic><topic>Toxicology</topic><topic>Venom</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ozkan, Ozcan</creatorcontrib><creatorcontrib>Carhan, Ahmet</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicon (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ozkan, Ozcan</au><au>Carhan, Ahmet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The neutralizing capacity of Androctonus crassicauda antivenom against Mesobuthus eupeus scorpion venom</atitle><jtitle>Toxicon (Oxford)</jtitle><addtitle>Toxicon</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>52</volume><issue>2</issue><spage>375</spage><epage>379</epage><pages>375-379</pages><issn>0041-0101</issn><eissn>1879-3150</eissn><coden>TOXIA6</coden><abstract>Scorpion envenomations are considerable health problem in tropical and subtropical regions. There are approximately 1500 species of scorpions worldwide. The number of dangerous species in the Buthidae family is significantly higher than in other families of scorpions.
Mesobuthus eupeus is a member of
Mesobuthus genus, Buthidae family. In this study, the potency and para-specific activities of
Androctonus crassicauda antivenom were investigated against
M. eupeus scorpion venom.
The median lethal dose of
M. eupeus and
A. crassicauda scorpion venoms were found to be 0.18
mg/kg, 15.45
μg/kg by i.c.v injection route. The antivenom showed neutralization effect against the venoms of
M. eupeus. One milliliter of
A. crassicauda antivenom neutralizes 464LD
50 of
M. eupeus and 940LD
50
A. crassicauda venom on mice. Western blotting demonstrated immunologic reaction with the venoms. The monovalent antivenom has immunoactivity and neutralizing capacity to the scorpion venoms. This study indicates that the antivenom produced by Refik Saydam Hygiene Center could be used for the treatment of
M. eupeus stings in Turkey.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>18625264</pmid><doi>10.1016/j.toxicon.2008.06.019</doi><tpages>5</tpages></addata></record> |
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| subjects | Androctonus crassicauda Androctonus crassicauda antivenom Animal poisons toxicology. Antivenoms Animals Antivenins - therapeutic use Biological and medical sciences Buthidae Disease Models, Animal Dose-Response Relationship, Drug Lethal Dose 50 Medical sciences Mesobuthus eupeus Mice Neutralization Tests Para-specific activity Scorpion Scorpion Venoms - chemistry Scorpion Venoms - immunology Scorpion Venoms - toxicity Scorpions - physiology Species Specificity Toxicology Venom |
| title | The neutralizing capacity of Androctonus crassicauda antivenom against Mesobuthus eupeus scorpion venom |
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