Metformin Plus Caloric Restriction Show Anti-epileptic Effects Mediated by mTOR Pathway Inhibition

Caloric restriction (CR) has anti-epileptic effects in different animal models, at least partially due to inhibition of the mechanistic or mammalian target of rapamycin (mTOR) signaling pathway. Adenosine monophosphate-activated protein kinase (AMPK) inhibits mTOR cascade function if energy levels a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cellular and molecular neurobiology 2018-10, Vol.38 (7), p.1425-1438
Hauptverfasser:	Rubio Osornio, María del Carmen, Custodio Ramírez, Verónica, Calderón Gámez, Daniela, Paz Tres, Carlos, Carvajal Aguilera, Karla G., Phillips Farfán, Bryan V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine kinase AMP AMP-Activated Protein Kinases - metabolism Animal models Animals Anticonvulsants - pharmacology Biomedical and Life Sciences Biomedicine Body weight Caloric Restriction Cell Biology Clinical trials Combined Modality Therapy Dietary restrictions Enzyme Inhibitors - therapeutic use Epilepsy Epilepsy - prevention & control Kinases Kindling Male Metabolic syndrome Metformin Metformin - therapeutic use Neocortex Neurobiology Neurosciences Obesity - complications Obesity - therapy Original Research Overweight Protein kinase Rapamycin Rats Rats, Wistar Seizures Signal transduction Signal Transduction - drug effects TOR protein TOR Serine-Threonine Kinases - antagonists & inhibitors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!