T1 and T2 mapping in the identification of acute myocardial injury in patients with NSTEMI
Aims To test T1 and T2 mapping in the assessment of acute myocardial injury in patients with non-ST-segment elevation myocardial infarction (NSTEMI), evaluated before revascularization. Methods Forty-seven patients with acute NSTEMI underwent cardiac magnetic resonance (CMR) at 1.5 T, including T1 a...
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| Veröffentlicht in: | Radiologia medica 2018-12, Vol.123 (12), p.926-934 |
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| container_title | Radiologia medica |
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| creator | Tessa, Carlo Del Meglio, Jacopo Lilli, Alessio Diciotti, Stefano Salvatori, Luca Giannelli, Marco Greiser, Andreas Vignali, Claudio Casolo, Giancarlo |
| description | Aims
To test T1 and T2 mapping in the assessment of acute myocardial injury in patients with non-ST-segment elevation myocardial infarction (NSTEMI), evaluated before revascularization.
Methods
Forty-seven patients with acute NSTEMI underwent cardiac magnetic resonance (CMR) at 1.5 T, including T1 and T2 mapping.
Results
Coronary angiography (CA) evidenced an obstructive coronary artery disease (CAD) in 36 patients (80%) and a non-obstructive CAD in 11 patients (20%). Edema was detected in 51.1/65.9% of patients in T1/T2 maps, respectively. This difference was due to artifacts in T1 maps. T1/T2 values were significantly higher in the infarcted myocardium (IM) compared with the remote myocardium (RM) (in T1: 1151.6 ± 53.5 ms vs. 958.2 ± 38.6 ms, respectively; in T2: 69 ± 6 ms vs. 51.9 ± 2.9 ms, respectively;
p
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| doi_str_mv | 10.1007/s11547-018-0931-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2091820948</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2134377908</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-91b2ee0f88f8264b428449ab8e61d0fcda4ab24f3dedc7e97880f4061eb85263</originalsourceid><addsrcrecordid>eNp1kMlKBDEQhoMoOi4P4EUCXry0ViWxOzmKuIHLwT55CenuRDNMLybdyLy9GcYFBE91qO__q_gIOUQ4RYDiLCKeiyIDlBkojhnbIDOULM9yJfkmmQFwnkmesx2yG-McQACC2iY7HJAzlHxGXkqkpmtoyWhrhsF3r9R3dHyz1De2G73ztRl939HeUVNPo6Xtsq9NaLxZJHI-heUqMCQo4ZF--PGNPj6XVw93-2TLmUW0B19zj5TXV-XlbXb_dHN3eXGf1bxgY6awYtaCk9Kl10UlmBRCmUraHBtwdWOEqZhwvLFNXVhVSAlOQI62kucs53vkZF07hP59snHUrY-1XSxMZ_spagYqOQElZEKP_6Dzfgpdek4z5IIXhYIVhWuqDn2MwTo9BN-asNQIeuVdr73r5F2vvGuWMkdfzVPV2uYn8S06AWwNxLTqXm34Pf1_6yetu4vV</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2134377908</pqid></control><display><type>article</type><title>T1 and T2 mapping in the identification of acute myocardial injury in patients with NSTEMI</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Tessa, Carlo ; Del Meglio, Jacopo ; Lilli, Alessio ; Diciotti, Stefano ; Salvatori, Luca ; Giannelli, Marco ; Greiser, Andreas ; Vignali, Claudio ; Casolo, Giancarlo</creator><creatorcontrib>Tessa, Carlo ; Del Meglio, Jacopo ; Lilli, Alessio ; Diciotti, Stefano ; Salvatori, Luca ; Giannelli, Marco ; Greiser, Andreas ; Vignali, Claudio ; Casolo, Giancarlo</creatorcontrib><description>Aims
To test T1 and T2 mapping in the assessment of acute myocardial injury in patients with non-ST-segment elevation myocardial infarction (NSTEMI), evaluated before revascularization.
Methods
Forty-seven patients with acute NSTEMI underwent cardiac magnetic resonance (CMR) at 1.5 T, including T1 and T2 mapping.
Results
Coronary angiography (CA) evidenced an obstructive coronary artery disease (CAD) in 36 patients (80%) and a non-obstructive CAD in 11 patients (20%). Edema was detected in 51.1/65.9% of patients in T1/T2 maps, respectively. This difference was due to artifacts in T1 maps. T1/T2 values were significantly higher in the infarcted myocardium (IM) compared with the remote myocardium (RM) (in T1: 1151.6 ± 53.5 ms vs. 958.2 ± 38.6 ms, respectively; in T2: 69 ± 6 ms vs. 51.9 ± 2.9 ms, respectively;
p
< 0.0001 for both). We found both an obstructive CAD at CA and myocardial edema at CMR in 53.2% of patients, while 8.5% of patients had a non-obstructive CAD and no edema. However, 25.5% of patients had an obstructive CAD without edema, while 12.8% of patients showed edema despite a non-obstructive CAD. Furthermore, in 6 of the edema-positive patients with multi-vessels obstructive CAD, CMR identified myocardial edema in a vascular territory different from that of the lesion supposed to be the culprit at CA.
Conclusions
In a non-negligible percentage of NSTEMI patients, T1 and T2 mapping detect myocardial edema without significant stenosis at CA and vice versa. Therefore, CA and CMR edema imaging might provide complementary information in the evaluation of NSTEMI.</description><identifier>ISSN: 0033-8362</identifier><identifier>EISSN: 1826-6983</identifier><identifier>DOI: 10.1007/s11547-018-0931-2</identifier><identifier>PMID: 30132183</identifier><language>eng</language><publisher>Milan: Springer Milan</publisher><subject>Angiography ; Blood vessels ; Cardiac Radiology ; Cardiovascular disease ; Contrast Media ; Coronary Angiography ; Coronary artery disease ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - pathology ; Diagnostic Radiology ; Edema ; Edema - diagnostic imaging ; Edema - pathology ; Electrocardiography ; Female ; Gadolinium ; Gadolinium DTPA ; Heterocyclic Compounds ; Humans ; Image Interpretation, Computer-Assisted ; Imaging ; Interventional Radiology ; Magnetic resonance ; Magnetic Resonance Imaging - methods ; Magnetic Resonance Imaging, Cine ; Male ; Mapping ; Medicine ; Medicine & Public Health ; Middle Aged ; Myocardial infarction ; Myocardium ; Neuroradiology ; Non-ST Elevated Myocardial Infarction - diagnostic imaging ; Non-ST Elevated Myocardial Infarction - pathology ; Organometallic Compounds ; Patients ; Radiology ; Ultrasound</subject><ispartof>Radiologia medica, 2018-12, Vol.123 (12), p.926-934</ispartof><rights>Italian Society of Medical Radiology 2018</rights><rights>Copyright Springer Science & Business Media 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-91b2ee0f88f8264b428449ab8e61d0fcda4ab24f3dedc7e97880f4061eb85263</citedby><cites>FETCH-LOGICAL-c372t-91b2ee0f88f8264b428449ab8e61d0fcda4ab24f3dedc7e97880f4061eb85263</cites><orcidid>0000-0001-7624-5168</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11547-018-0931-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11547-018-0931-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30132183$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tessa, Carlo</creatorcontrib><creatorcontrib>Del Meglio, Jacopo</creatorcontrib><creatorcontrib>Lilli, Alessio</creatorcontrib><creatorcontrib>Diciotti, Stefano</creatorcontrib><creatorcontrib>Salvatori, Luca</creatorcontrib><creatorcontrib>Giannelli, Marco</creatorcontrib><creatorcontrib>Greiser, Andreas</creatorcontrib><creatorcontrib>Vignali, Claudio</creatorcontrib><creatorcontrib>Casolo, Giancarlo</creatorcontrib><title>T1 and T2 mapping in the identification of acute myocardial injury in patients with NSTEMI</title><title>Radiologia medica</title><addtitle>Radiol med</addtitle><addtitle>Radiol Med</addtitle><description>Aims
To test T1 and T2 mapping in the assessment of acute myocardial injury in patients with non-ST-segment elevation myocardial infarction (NSTEMI), evaluated before revascularization.
Methods
Forty-seven patients with acute NSTEMI underwent cardiac magnetic resonance (CMR) at 1.5 T, including T1 and T2 mapping.
Results
Coronary angiography (CA) evidenced an obstructive coronary artery disease (CAD) in 36 patients (80%) and a non-obstructive CAD in 11 patients (20%). Edema was detected in 51.1/65.9% of patients in T1/T2 maps, respectively. This difference was due to artifacts in T1 maps. T1/T2 values were significantly higher in the infarcted myocardium (IM) compared with the remote myocardium (RM) (in T1: 1151.6 ± 53.5 ms vs. 958.2 ± 38.6 ms, respectively; in T2: 69 ± 6 ms vs. 51.9 ± 2.9 ms, respectively;
p
< 0.0001 for both). We found both an obstructive CAD at CA and myocardial edema at CMR in 53.2% of patients, while 8.5% of patients had a non-obstructive CAD and no edema. However, 25.5% of patients had an obstructive CAD without edema, while 12.8% of patients showed edema despite a non-obstructive CAD. Furthermore, in 6 of the edema-positive patients with multi-vessels obstructive CAD, CMR identified myocardial edema in a vascular territory different from that of the lesion supposed to be the culprit at CA.
Conclusions
In a non-negligible percentage of NSTEMI patients, T1 and T2 mapping detect myocardial edema without significant stenosis at CA and vice versa. Therefore, CA and CMR edema imaging might provide complementary information in the evaluation of NSTEMI.</description><subject>Angiography</subject><subject>Blood vessels</subject><subject>Cardiac Radiology</subject><subject>Cardiovascular disease</subject><subject>Contrast Media</subject><subject>Coronary Angiography</subject><subject>Coronary artery disease</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - pathology</subject><subject>Diagnostic Radiology</subject><subject>Edema</subject><subject>Edema - diagnostic imaging</subject><subject>Edema - pathology</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Gadolinium</subject><subject>Gadolinium DTPA</subject><subject>Heterocyclic Compounds</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted</subject><subject>Imaging</subject><subject>Interventional Radiology</subject><subject>Magnetic resonance</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Magnetic Resonance Imaging, Cine</subject><subject>Male</subject><subject>Mapping</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Myocardial infarction</subject><subject>Myocardium</subject><subject>Neuroradiology</subject><subject>Non-ST Elevated Myocardial Infarction - diagnostic imaging</subject><subject>Non-ST Elevated Myocardial Infarction - pathology</subject><subject>Organometallic Compounds</subject><subject>Patients</subject><subject>Radiology</subject><subject>Ultrasound</subject><issn>0033-8362</issn><issn>1826-6983</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMlKBDEQhoMoOi4P4EUCXry0ViWxOzmKuIHLwT55CenuRDNMLybdyLy9GcYFBE91qO__q_gIOUQ4RYDiLCKeiyIDlBkojhnbIDOULM9yJfkmmQFwnkmesx2yG-McQACC2iY7HJAzlHxGXkqkpmtoyWhrhsF3r9R3dHyz1De2G73ztRl939HeUVNPo6Xtsq9NaLxZJHI-heUqMCQo4ZF--PGNPj6XVw93-2TLmUW0B19zj5TXV-XlbXb_dHN3eXGf1bxgY6awYtaCk9Kl10UlmBRCmUraHBtwdWOEqZhwvLFNXVhVSAlOQI62kucs53vkZF07hP59snHUrY-1XSxMZ_spagYqOQElZEKP_6Dzfgpdek4z5IIXhYIVhWuqDn2MwTo9BN-asNQIeuVdr73r5F2vvGuWMkdfzVPV2uYn8S06AWwNxLTqXm34Pf1_6yetu4vV</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Tessa, Carlo</creator><creator>Del Meglio, Jacopo</creator><creator>Lilli, Alessio</creator><creator>Diciotti, Stefano</creator><creator>Salvatori, Luca</creator><creator>Giannelli, Marco</creator><creator>Greiser, Andreas</creator><creator>Vignali, Claudio</creator><creator>Casolo, Giancarlo</creator><general>Springer Milan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7624-5168</orcidid></search><sort><creationdate>20181201</creationdate><title>T1 and T2 mapping in the identification of acute myocardial injury in patients with NSTEMI</title><author>Tessa, Carlo ; Del Meglio, Jacopo ; Lilli, Alessio ; Diciotti, Stefano ; Salvatori, Luca ; Giannelli, Marco ; Greiser, Andreas ; Vignali, Claudio ; Casolo, Giancarlo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-91b2ee0f88f8264b428449ab8e61d0fcda4ab24f3dedc7e97880f4061eb85263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Angiography</topic><topic>Blood vessels</topic><topic>Cardiac Radiology</topic><topic>Cardiovascular disease</topic><topic>Contrast Media</topic><topic>Coronary Angiography</topic><topic>Coronary artery disease</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Artery Disease - pathology</topic><topic>Diagnostic Radiology</topic><topic>Edema</topic><topic>Edema - diagnostic imaging</topic><topic>Edema - pathology</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Gadolinium</topic><topic>Gadolinium DTPA</topic><topic>Heterocyclic Compounds</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted</topic><topic>Imaging</topic><topic>Interventional Radiology</topic><topic>Magnetic resonance</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Magnetic Resonance Imaging, Cine</topic><topic>Male</topic><topic>Mapping</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Myocardial infarction</topic><topic>Myocardium</topic><topic>Neuroradiology</topic><topic>Non-ST Elevated Myocardial Infarction - diagnostic imaging</topic><topic>Non-ST Elevated Myocardial Infarction - pathology</topic><topic>Organometallic Compounds</topic><topic>Patients</topic><topic>Radiology</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tessa, Carlo</creatorcontrib><creatorcontrib>Del Meglio, Jacopo</creatorcontrib><creatorcontrib>Lilli, Alessio</creatorcontrib><creatorcontrib>Diciotti, Stefano</creatorcontrib><creatorcontrib>Salvatori, Luca</creatorcontrib><creatorcontrib>Giannelli, Marco</creatorcontrib><creatorcontrib>Greiser, Andreas</creatorcontrib><creatorcontrib>Vignali, Claudio</creatorcontrib><creatorcontrib>Casolo, Giancarlo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Radiologia medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tessa, Carlo</au><au>Del Meglio, Jacopo</au><au>Lilli, Alessio</au><au>Diciotti, Stefano</au><au>Salvatori, Luca</au><au>Giannelli, Marco</au><au>Greiser, Andreas</au><au>Vignali, Claudio</au><au>Casolo, Giancarlo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>T1 and T2 mapping in the identification of acute myocardial injury in patients with NSTEMI</atitle><jtitle>Radiologia medica</jtitle><stitle>Radiol med</stitle><addtitle>Radiol Med</addtitle><date>2018-12-01</date><risdate>2018</risdate><volume>123</volume><issue>12</issue><spage>926</spage><epage>934</epage><pages>926-934</pages><issn>0033-8362</issn><eissn>1826-6983</eissn><abstract>Aims
To test T1 and T2 mapping in the assessment of acute myocardial injury in patients with non-ST-segment elevation myocardial infarction (NSTEMI), evaluated before revascularization.
Methods
Forty-seven patients with acute NSTEMI underwent cardiac magnetic resonance (CMR) at 1.5 T, including T1 and T2 mapping.
Results
Coronary angiography (CA) evidenced an obstructive coronary artery disease (CAD) in 36 patients (80%) and a non-obstructive CAD in 11 patients (20%). Edema was detected in 51.1/65.9% of patients in T1/T2 maps, respectively. This difference was due to artifacts in T1 maps. T1/T2 values were significantly higher in the infarcted myocardium (IM) compared with the remote myocardium (RM) (in T1: 1151.6 ± 53.5 ms vs. 958.2 ± 38.6 ms, respectively; in T2: 69 ± 6 ms vs. 51.9 ± 2.9 ms, respectively;
p
< 0.0001 for both). We found both an obstructive CAD at CA and myocardial edema at CMR in 53.2% of patients, while 8.5% of patients had a non-obstructive CAD and no edema. However, 25.5% of patients had an obstructive CAD without edema, while 12.8% of patients showed edema despite a non-obstructive CAD. Furthermore, in 6 of the edema-positive patients with multi-vessels obstructive CAD, CMR identified myocardial edema in a vascular territory different from that of the lesion supposed to be the culprit at CA.
Conclusions
In a non-negligible percentage of NSTEMI patients, T1 and T2 mapping detect myocardial edema without significant stenosis at CA and vice versa. Therefore, CA and CMR edema imaging might provide complementary information in the evaluation of NSTEMI.</abstract><cop>Milan</cop><pub>Springer Milan</pub><pmid>30132183</pmid><doi>10.1007/s11547-018-0931-2</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-7624-5168</orcidid></addata></record> |
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| issn | 0033-8362 1826-6983 |
| language | eng |
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| subjects | Angiography Blood vessels Cardiac Radiology Cardiovascular disease Contrast Media Coronary Angiography Coronary artery disease Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - pathology Diagnostic Radiology Edema Edema - diagnostic imaging Edema - pathology Electrocardiography Female Gadolinium Gadolinium DTPA Heterocyclic Compounds Humans Image Interpretation, Computer-Assisted Imaging Interventional Radiology Magnetic resonance Magnetic Resonance Imaging - methods Magnetic Resonance Imaging, Cine Male Mapping Medicine Medicine & Public Health Middle Aged Myocardial infarction Myocardium Neuroradiology Non-ST Elevated Myocardial Infarction - diagnostic imaging Non-ST Elevated Myocardial Infarction - pathology Organometallic Compounds Patients Radiology Ultrasound |
| title | T1 and T2 mapping in the identification of acute myocardial injury in patients with NSTEMI |
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