Catalytic Asymmetric [4+2]‐Cycloadditions Using Tropolones: Developments, Scope, Transformations, and Bioactivity

An organocatalyzed asymmetric [4+2]‐cycloaddition between tropolones and electron‐deficient dienophiles is presented. Complex and biologically interesting dihydrohomobarrelenone scaffolds are formed through a Diels–Alder reaction utilizing bifunctional Brønsted‐base catalysis, affording the correspo...

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Veröffentlicht in:	Angewandte Chemie International Edition 2018-10, Vol.57 (40), p.13216-13220
Hauptverfasser:	Hammer, Niels, Erickson, Jeremy D., Lauridsen, Vibeke H., Jakobsen, Joakim B., Hansen, Bente K., Jacobsen, Kristian M., Poulsen, Thomas B., Jørgensen, Karl Anker
Format:	Artikel
Sprache:	eng
Schlagworte:	bioactivity Biocompatibility Biological activity Biomedical materials Bridged Bicyclo Compounds, Heterocyclic - chemistry Cancer Catalysis Cell Survival - drug effects Cycloaddition Cycloaddition Reaction Humans In vivo methods and tests MCF-7 Cells organocatalysis Palladium - chemistry photoisomerization Stereoisomerism Stereoselectivity Transformations tropolone Tropolone - chemistry Tropolone - pharmacology
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