LncRNA AK077216 promotes RANKL‐induced osteoclastogenesis and bone resorption via NFATc1 by inhibition of NIP45

Osteoclasts derived from the monocyte/macrophage hematopoietic lineage regulate bone resorption, a process balanced by bone formation in the continual renewal of the skeletal system. As dysfunctions of these cells result in bone metabolic diseases such as osteoporosis and osteopetrosis, the explorat...

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Veröffentlicht in:	Journal of cellular physiology 2019-02, Vol.234 (2), p.1606-1617
Hauptverfasser:	Liu, Chuan, Cao, Zhen, Bai, Yun, Dou, Ce, Gong, Xiaoshan, Liang, Mengmeng, Dong, Rui, Quan, Hongyu, Li, Jianmei, Dai, Jingjin, Kang, Fei, Zhao, Chunrong, Dong, Shiwu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid phosphatase Acid phosphatase (tartrate-resistant) Acid resistance AK077216 Animals Apoptosis Apoptosis - drug effects Biocompatibility Biomarkers Bone growth Bone marrow Bone Resorption Differentiation Disease Models, Animal DNA microarrays Female Gene expression Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism long noncoding RNA (lncRNAs) Macrophages Macrophages - drug effects Macrophages - enzymology Macrophages - pathology Metabolic disorders Mice Mice, Inbred C57BL Monocytes NFATC Transcription Factors - genetics NFATC Transcription Factors - metabolism NFATc1 NIP45 Osteoclastogenesis Osteoclasts Osteoclasts - drug effects Osteoclasts - enzymology Osteoclasts - pathology Osteogenesis Osteogenesis - drug effects Osteopetrosis Osteoporosis Osteoporosis, Postmenopausal - enzymology Osteoporosis, Postmenopausal - genetics Osteoporosis, Postmenopausal - pathology Ovariectomy RANK Ligand - pharmacology RAW 264.7 Cells RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Signal Transduction Skeletal system Spleen TRANCE protein
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