LncRNA AK077216 promotes RANKL‐induced osteoclastogenesis and bone resorption via NFATc1 by inhibition of NIP45
Osteoclasts derived from the monocyte/macrophage hematopoietic lineage regulate bone resorption, a process balanced by bone formation in the continual renewal of the skeletal system. As dysfunctions of these cells result in bone metabolic diseases such as osteoporosis and osteopetrosis, the explorat...
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| Veröffentlicht in: | Journal of cellular physiology 2019-02, Vol.234 (2), p.1606-1617 |
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| creator | Liu, Chuan Cao, Zhen Bai, Yun Dou, Ce Gong, Xiaoshan Liang, Mengmeng Dong, Rui Quan, Hongyu Li, Jianmei Dai, Jingjin Kang, Fei Zhao, Chunrong Dong, Shiwu |
| description | Osteoclasts derived from the monocyte/macrophage hematopoietic lineage regulate bone resorption, a process balanced by bone formation in the continual renewal of the skeletal system. As dysfunctions of these cells result in bone metabolic diseases such as osteoporosis and osteopetrosis, the exploration of the mechanisms regulating their differentiation is a priority. A potential mechanism may involve long noncoding RNAs (lncRNAs), which are known to regulate various cell biology activities, including proliferation, differentiation, and apoptosis. The expression of the lncRNA AK077216 (Lnc‐AK077216) is significantly upregulated during osteoclastogenesis identified by microarray and verified by qPCR. Up‐ and downregulation of Lnc‐AK077216, respectively promotes and inhibits osteoclast differentiation, bone resorption, and the expression of related genes on the basis of tartrate‐resistant acid phosphatase staining, qPCR, and western blot results. In addition, Lnc‐AK077216 suppresses NIP45 expression and promotes the expression of NFATc1, an essential transcription factor during osteoclastogenesis. Besides, it was found that the expression of Lnc‐AK077216 and Nfatc1 is upregulated, whereas Nip45 expression is downregulated in bone marrow and spleen tissues of ovariectomized mice. The results suggest that Lnc‐AK077216 regulates NFATc1 expression and promotes osteoclast formation and function, providing a novel mechanism of osteoclastogenesis and a potential biomarker or a new drug target for osteoporosis.
Lnc‐AK077216 promotes the expression of NFATc1 via suppressing NIP45 expression, thereby promoting RANKL‐induced osteoclast differentiation and function. |
| doi_str_mv | 10.1002/jcp.27031 |
| format | Article |
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Lnc‐AK077216 promotes the expression of NFATc1 via suppressing NIP45 expression, thereby promoting RANKL‐induced osteoclast differentiation and function.</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.27031</identifier><identifier>PMID: 30132869</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Acid phosphatase ; Acid phosphatase (tartrate-resistant) ; Acid resistance ; AK077216 ; Animals ; Apoptosis ; Apoptosis - drug effects ; Biocompatibility ; Biomarkers ; Bone growth ; Bone marrow ; Bone Resorption ; Differentiation ; Disease Models, Animal ; DNA microarrays ; Female ; Gene expression ; Humans ; Intracellular Signaling Peptides and Proteins - genetics ; Intracellular Signaling Peptides and Proteins - metabolism ; long noncoding RNA (lncRNAs) ; Macrophages ; Macrophages - drug effects ; Macrophages - enzymology ; Macrophages - pathology ; Metabolic disorders ; Mice ; Mice, Inbred C57BL ; Monocytes ; NFATC Transcription Factors - genetics ; NFATC Transcription Factors - metabolism ; NFATc1 ; NIP45 ; Osteoclastogenesis ; Osteoclasts ; Osteoclasts - drug effects ; Osteoclasts - enzymology ; Osteoclasts - pathology ; Osteogenesis ; Osteogenesis - drug effects ; Osteopetrosis ; Osteoporosis ; Osteoporosis, Postmenopausal - enzymology ; Osteoporosis, Postmenopausal - genetics ; Osteoporosis, Postmenopausal - pathology ; Ovariectomy ; RANK Ligand - pharmacology ; RAW 264.7 Cells ; RNA, Long Noncoding - genetics ; RNA, Long Noncoding - metabolism ; Signal Transduction ; Skeletal system ; Spleen ; TRANCE protein</subject><ispartof>Journal of cellular physiology, 2019-02, Vol.234 (2), p.1606-1617</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3531-3bc116b534a6aeb2371639c1cdd94995b56446f7e738d351c290b48ccbac4c923</citedby><cites>FETCH-LOGICAL-c3531-3bc116b534a6aeb2371639c1cdd94995b56446f7e738d351c290b48ccbac4c923</cites><orcidid>0000-0002-6983-6354 ; 0000-0002-5032-4893</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcp.27031$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcp.27031$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30132869$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Chuan</creatorcontrib><creatorcontrib>Cao, Zhen</creatorcontrib><creatorcontrib>Bai, Yun</creatorcontrib><creatorcontrib>Dou, Ce</creatorcontrib><creatorcontrib>Gong, Xiaoshan</creatorcontrib><creatorcontrib>Liang, Mengmeng</creatorcontrib><creatorcontrib>Dong, Rui</creatorcontrib><creatorcontrib>Quan, Hongyu</creatorcontrib><creatorcontrib>Li, Jianmei</creatorcontrib><creatorcontrib>Dai, Jingjin</creatorcontrib><creatorcontrib>Kang, Fei</creatorcontrib><creatorcontrib>Zhao, Chunrong</creatorcontrib><creatorcontrib>Dong, Shiwu</creatorcontrib><title>LncRNA AK077216 promotes RANKL‐induced osteoclastogenesis and bone resorption via NFATc1 by inhibition of NIP45</title><title>Journal of cellular physiology</title><addtitle>J Cell Physiol</addtitle><description>Osteoclasts derived from the monocyte/macrophage hematopoietic lineage regulate bone resorption, a process balanced by bone formation in the continual renewal of the skeletal system. As dysfunctions of these cells result in bone metabolic diseases such as osteoporosis and osteopetrosis, the exploration of the mechanisms regulating their differentiation is a priority. A potential mechanism may involve long noncoding RNAs (lncRNAs), which are known to regulate various cell biology activities, including proliferation, differentiation, and apoptosis. The expression of the lncRNA AK077216 (Lnc‐AK077216) is significantly upregulated during osteoclastogenesis identified by microarray and verified by qPCR. Up‐ and downregulation of Lnc‐AK077216, respectively promotes and inhibits osteoclast differentiation, bone resorption, and the expression of related genes on the basis of tartrate‐resistant acid phosphatase staining, qPCR, and western blot results. In addition, Lnc‐AK077216 suppresses NIP45 expression and promotes the expression of NFATc1, an essential transcription factor during osteoclastogenesis. Besides, it was found that the expression of Lnc‐AK077216 and Nfatc1 is upregulated, whereas Nip45 expression is downregulated in bone marrow and spleen tissues of ovariectomized mice. The results suggest that Lnc‐AK077216 regulates NFATc1 expression and promotes osteoclast formation and function, providing a novel mechanism of osteoclastogenesis and a potential biomarker or a new drug target for osteoporosis.
Lnc‐AK077216 promotes the expression of NFATc1 via suppressing NIP45 expression, thereby promoting RANKL‐induced osteoclast differentiation and function.</description><subject>Acid phosphatase</subject><subject>Acid phosphatase (tartrate-resistant)</subject><subject>Acid resistance</subject><subject>AK077216</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Biocompatibility</subject><subject>Biomarkers</subject><subject>Bone growth</subject><subject>Bone marrow</subject><subject>Bone Resorption</subject><subject>Differentiation</subject><subject>Disease Models, Animal</subject><subject>DNA microarrays</subject><subject>Female</subject><subject>Gene expression</subject><subject>Humans</subject><subject>Intracellular Signaling Peptides and Proteins - genetics</subject><subject>Intracellular Signaling Peptides and Proteins - metabolism</subject><subject>long noncoding RNA (lncRNAs)</subject><subject>Macrophages</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - enzymology</subject><subject>Macrophages - pathology</subject><subject>Metabolic disorders</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Monocytes</subject><subject>NFATC Transcription Factors - genetics</subject><subject>NFATC Transcription Factors - metabolism</subject><subject>NFATc1</subject><subject>NIP45</subject><subject>Osteoclastogenesis</subject><subject>Osteoclasts</subject><subject>Osteoclasts - drug effects</subject><subject>Osteoclasts - enzymology</subject><subject>Osteoclasts - pathology</subject><subject>Osteogenesis</subject><subject>Osteogenesis - drug effects</subject><subject>Osteopetrosis</subject><subject>Osteoporosis</subject><subject>Osteoporosis, Postmenopausal - enzymology</subject><subject>Osteoporosis, Postmenopausal - genetics</subject><subject>Osteoporosis, Postmenopausal - pathology</subject><subject>Ovariectomy</subject><subject>RANK Ligand - pharmacology</subject><subject>RAW 264.7 Cells</subject><subject>RNA, Long Noncoding - genetics</subject><subject>RNA, Long Noncoding - metabolism</subject><subject>Signal Transduction</subject><subject>Skeletal system</subject><subject>Spleen</subject><subject>TRANCE protein</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1OGzEURq0KVALtoi-ALLEpiwm-_pt4OYqAAlEaIbq2bI9THE3sMJ4pyo5H4Bn7JAyEdlGpq7v4jo7uvR9CX4CMgRB6tnKbMS0Jgw9oBESVBZeC7qHRkEGhBIcDdJjzihCiFGMf0QEjwOhEqhF6mEV3O69wdUPKkoLEmzatU-czvq3mN7PfT88h1r3zNU6588k1Jnfpp48-h4xNrLFN0ePW59RuupAi_hUMnl9Udw6w3eIQ74MNb0Fa4vnVgotPaH9pmuw_v88j9OPi_G76rZh9v7yaVrPCMcGgYNYBSCsYN9J4S1kJkikHrq4VV0pYITmXy9KXbFIzAY4qYvnEOWscd4qyI_R15x0ueuh97vQ6ZOebxkSf-qwpUTABrjgf0JN_0FXq2zhspykwIVQppBio0x3l2pRz65d604a1abcaiH7tQQ896LceBvb43djbta__kn8ePwBnO-AxNH77f5O-ni52yhd9Oo9z</recordid><startdate>201902</startdate><enddate>201902</enddate><creator>Liu, Chuan</creator><creator>Cao, Zhen</creator><creator>Bai, Yun</creator><creator>Dou, Ce</creator><creator>Gong, Xiaoshan</creator><creator>Liang, Mengmeng</creator><creator>Dong, Rui</creator><creator>Quan, Hongyu</creator><creator>Li, Jianmei</creator><creator>Dai, Jingjin</creator><creator>Kang, Fei</creator><creator>Zhao, Chunrong</creator><creator>Dong, Shiwu</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6983-6354</orcidid><orcidid>https://orcid.org/0000-0002-5032-4893</orcidid></search><sort><creationdate>201902</creationdate><title>LncRNA AK077216 promotes RANKL‐induced osteoclastogenesis and bone resorption via NFATc1 by inhibition of NIP45</title><author>Liu, Chuan ; Cao, Zhen ; Bai, Yun ; Dou, Ce ; Gong, Xiaoshan ; Liang, Mengmeng ; Dong, Rui ; Quan, Hongyu ; Li, Jianmei ; Dai, Jingjin ; Kang, Fei ; Zhao, Chunrong ; Dong, Shiwu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3531-3bc116b534a6aeb2371639c1cdd94995b56446f7e738d351c290b48ccbac4c923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acid phosphatase</topic><topic>Acid phosphatase (tartrate-resistant)</topic><topic>Acid resistance</topic><topic>AK077216</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Biocompatibility</topic><topic>Biomarkers</topic><topic>Bone growth</topic><topic>Bone marrow</topic><topic>Bone Resorption</topic><topic>Differentiation</topic><topic>Disease Models, Animal</topic><topic>DNA microarrays</topic><topic>Female</topic><topic>Gene expression</topic><topic>Humans</topic><topic>Intracellular Signaling Peptides and Proteins - genetics</topic><topic>Intracellular Signaling Peptides and Proteins - metabolism</topic><topic>long noncoding RNA (lncRNAs)</topic><topic>Macrophages</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - enzymology</topic><topic>Macrophages - pathology</topic><topic>Metabolic disorders</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Monocytes</topic><topic>NFATC Transcription Factors - genetics</topic><topic>NFATC Transcription Factors - metabolism</topic><topic>NFATc1</topic><topic>NIP45</topic><topic>Osteoclastogenesis</topic><topic>Osteoclasts</topic><topic>Osteoclasts - drug effects</topic><topic>Osteoclasts - enzymology</topic><topic>Osteoclasts - pathology</topic><topic>Osteogenesis</topic><topic>Osteogenesis - drug effects</topic><topic>Osteopetrosis</topic><topic>Osteoporosis</topic><topic>Osteoporosis, Postmenopausal - enzymology</topic><topic>Osteoporosis, Postmenopausal - genetics</topic><topic>Osteoporosis, Postmenopausal - pathology</topic><topic>Ovariectomy</topic><topic>RANK Ligand - pharmacology</topic><topic>RAW 264.7 Cells</topic><topic>RNA, Long Noncoding - genetics</topic><topic>RNA, Long Noncoding - metabolism</topic><topic>Signal Transduction</topic><topic>Skeletal system</topic><topic>Spleen</topic><topic>TRANCE protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Chuan</creatorcontrib><creatorcontrib>Cao, Zhen</creatorcontrib><creatorcontrib>Bai, Yun</creatorcontrib><creatorcontrib>Dou, Ce</creatorcontrib><creatorcontrib>Gong, Xiaoshan</creatorcontrib><creatorcontrib>Liang, Mengmeng</creatorcontrib><creatorcontrib>Dong, Rui</creatorcontrib><creatorcontrib>Quan, Hongyu</creatorcontrib><creatorcontrib>Li, Jianmei</creatorcontrib><creatorcontrib>Dai, Jingjin</creatorcontrib><creatorcontrib>Kang, Fei</creatorcontrib><creatorcontrib>Zhao, Chunrong</creatorcontrib><creatorcontrib>Dong, Shiwu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Chuan</au><au>Cao, Zhen</au><au>Bai, Yun</au><au>Dou, Ce</au><au>Gong, Xiaoshan</au><au>Liang, Mengmeng</au><au>Dong, Rui</au><au>Quan, Hongyu</au><au>Li, Jianmei</au><au>Dai, Jingjin</au><au>Kang, Fei</au><au>Zhao, Chunrong</au><au>Dong, Shiwu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>LncRNA AK077216 promotes RANKL‐induced osteoclastogenesis and bone resorption via NFATc1 by inhibition of NIP45</atitle><jtitle>Journal of cellular physiology</jtitle><addtitle>J Cell Physiol</addtitle><date>2019-02</date><risdate>2019</risdate><volume>234</volume><issue>2</issue><spage>1606</spage><epage>1617</epage><pages>1606-1617</pages><issn>0021-9541</issn><eissn>1097-4652</eissn><abstract>Osteoclasts derived from the monocyte/macrophage hematopoietic lineage regulate bone resorption, a process balanced by bone formation in the continual renewal of the skeletal system. As dysfunctions of these cells result in bone metabolic diseases such as osteoporosis and osteopetrosis, the exploration of the mechanisms regulating their differentiation is a priority. A potential mechanism may involve long noncoding RNAs (lncRNAs), which are known to regulate various cell biology activities, including proliferation, differentiation, and apoptosis. The expression of the lncRNA AK077216 (Lnc‐AK077216) is significantly upregulated during osteoclastogenesis identified by microarray and verified by qPCR. Up‐ and downregulation of Lnc‐AK077216, respectively promotes and inhibits osteoclast differentiation, bone resorption, and the expression of related genes on the basis of tartrate‐resistant acid phosphatase staining, qPCR, and western blot results. In addition, Lnc‐AK077216 suppresses NIP45 expression and promotes the expression of NFATc1, an essential transcription factor during osteoclastogenesis. Besides, it was found that the expression of Lnc‐AK077216 and Nfatc1 is upregulated, whereas Nip45 expression is downregulated in bone marrow and spleen tissues of ovariectomized mice. The results suggest that Lnc‐AK077216 regulates NFATc1 expression and promotes osteoclast formation and function, providing a novel mechanism of osteoclastogenesis and a potential biomarker or a new drug target for osteoporosis.
Lnc‐AK077216 promotes the expression of NFATc1 via suppressing NIP45 expression, thereby promoting RANKL‐induced osteoclast differentiation and function.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30132869</pmid><doi>10.1002/jcp.27031</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-6983-6354</orcidid><orcidid>https://orcid.org/0000-0002-5032-4893</orcidid></addata></record> |
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| subjects | Acid phosphatase Acid phosphatase (tartrate-resistant) Acid resistance AK077216 Animals Apoptosis Apoptosis - drug effects Biocompatibility Biomarkers Bone growth Bone marrow Bone Resorption Differentiation Disease Models, Animal DNA microarrays Female Gene expression Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism long noncoding RNA (lncRNAs) Macrophages Macrophages - drug effects Macrophages - enzymology Macrophages - pathology Metabolic disorders Mice Mice, Inbred C57BL Monocytes NFATC Transcription Factors - genetics NFATC Transcription Factors - metabolism NFATc1 NIP45 Osteoclastogenesis Osteoclasts Osteoclasts - drug effects Osteoclasts - enzymology Osteoclasts - pathology Osteogenesis Osteogenesis - drug effects Osteopetrosis Osteoporosis Osteoporosis, Postmenopausal - enzymology Osteoporosis, Postmenopausal - genetics Osteoporosis, Postmenopausal - pathology Ovariectomy RANK Ligand - pharmacology RAW 264.7 Cells RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Signal Transduction Skeletal system Spleen TRANCE protein |
| title | LncRNA AK077216 promotes RANKL‐induced osteoclastogenesis and bone resorption via NFATc1 by inhibition of NIP45 |
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