Impact of NS5A sequences of Hepatitis C virus genotype 1a on early viral kinetics during treatment with peginterferon- alpha 2a plus ribavirin

BACKGROUND. Hepatitis C virus (HCV) genotype 1 is the most prevalent genotype in Western countries, and treatment with pegylated interferon (pegIFN) plus ribavirin fails in 50%-60% of patients. Genetic variability within the NS5A dsRNA-dependent protein kinase binding domain (PKRbd) of HCV-1b has be...

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Veröffentlicht in:	The Journal of infectious diseases 2007-10, Vol.196 (7), p.998-1005
Hauptverfasser:	Dal Pero, Francesca, Tang, Kwok H, Gerotto, Martina, Bortoletto, Gladis, Paulon, Emma, Herrmann, Eva, Zeuzem, Stefan, Alberti, Alfredo, Naoumov, Nikolai V
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antiviral Agents - administration & dosage Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Drug Resistance, Viral Drug Therapy, Combination Genetic Variation Genotype Hepacivirus - classification Hepacivirus - drug effects Hepacivirus - genetics Hepatitis C virus Humans Interferon alpha-2 Interferon-alpha - administration & dosage Interferon-alpha - pharmacology Interferon-alpha - therapeutic use Kinetics Models, Biological Molecular Sequence Data Phylogeny Polyethylene Glycols - administration & dosage Polyethylene Glycols - pharmacology Polyethylene Glycols - therapeutic use Recombinant Proteins Ribavirin - administration & dosage Ribavirin - pharmacology Ribavirin - therapeutic use RNA, Viral - blood Sequence Alignment Sequence Analysis, DNA Treatment Outcome Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism
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