Antidesmoglein Autoantibodies in Silicosis Patients with No Bullous Diseases
Background: Pemphigus is an autoimmune bullous disease characterized by the presence of antidesmoglein autoantibodies. However, the mechanism of its autoantibody production remains unknown. In previous reports, we have described rare cases of pemphigus and pemphigoid associated with silicosis. It is...
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| Veröffentlicht in: | Dermatology (Basel) 2001-01, Vol.202 (1), p.16-21 |
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| creator | Ueki, H. Kohda, M. Nobutoh, T. Yamaguchi, M. Omori, K. Miyashita, Y. Hashimoto, T. Komai, A. Tomokuni, A. Ueki, A. |
| description | Background: Pemphigus is an autoimmune bullous disease characterized by the presence of antidesmoglein autoantibodies. However, the mechanism of its autoantibody production remains unknown. In previous reports, we have described rare cases of pemphigus and pemphigoid associated with silicosis. It is well known that during long-term silicosis, some autoimmune diseases, such as systemic sclerosis, systemic lupus erythematosus or rheumatoid arthritis, can occur. Objective: The aim of this study was to explore the presence of pemphigus or pemphigoid autoantibodies in silicosis patients without clinical bullous diseases or collagen diseases. Method: The presence of pemphigus antibodies was examined in 54 silicosis patients with no associated bullous diseases, using immunofluorescence, the enzyme-linked immunosorbent assay (ELISA) for desmoglein 1 and 3, and immunoblotting methods. In the antibody-positive cases, HLA genotyping of peripheral lymphocytes was performed with PCR-RFLP. Results: Seven out of the 54 patients were found to be positive for pemphigus antibodies and 1 for bullous pemphigoid by immunofluorescence. In addition, by ELISA, 6 patients were found to be positive against the desmoglein 1 antigen, 2 against the desmoglein 3 antigen and 2 against both desmoglein 1 and desmoglein 3. Conclusion: The results of the present study strongly suggest the occurrence of pemphigus and pemphigoid autoantibodies in patients with silicosis. It remains unclear whether such patients will develop an autoimmune bullous disease in the future. Accordingly, long-term follow-up of antibody-positive patients is required. |
| doi_str_mv | 10.1159/000051578 |
| format | Article |
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However, the mechanism of its autoantibody production remains unknown. In previous reports, we have described rare cases of pemphigus and pemphigoid associated with silicosis. It is well known that during long-term silicosis, some autoimmune diseases, such as systemic sclerosis, systemic lupus erythematosus or rheumatoid arthritis, can occur. Objective: The aim of this study was to explore the presence of pemphigus or pemphigoid autoantibodies in silicosis patients without clinical bullous diseases or collagen diseases. Method: The presence of pemphigus antibodies was examined in 54 silicosis patients with no associated bullous diseases, using immunofluorescence, the enzyme-linked immunosorbent assay (ELISA) for desmoglein 1 and 3, and immunoblotting methods. In the antibody-positive cases, HLA genotyping of peripheral lymphocytes was performed with PCR-RFLP. Results: Seven out of the 54 patients were found to be positive for pemphigus antibodies and 1 for bullous pemphigoid by immunofluorescence. In addition, by ELISA, 6 patients were found to be positive against the desmoglein 1 antigen, 2 against the desmoglein 3 antigen and 2 against both desmoglein 1 and desmoglein 3. Conclusion: The results of the present study strongly suggest the occurrence of pemphigus and pemphigoid autoantibodies in patients with silicosis. It remains unclear whether such patients will develop an autoimmune bullous disease in the future. Accordingly, long-term follow-up of antibody-positive patients is required.</description><identifier>ISSN: 1018-8665</identifier><identifier>EISSN: 1421-9832</identifier><identifier>DOI: 10.1159/000051578</identifier><identifier>PMID: 11244222</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Aged ; Aged, 80 and over ; Autoantibodies - blood ; Biological and medical sciences ; Chemical and industrial products toxicology. Toxic occupational diseases ; Clinical and Laboratory Investigations ; Cytoskeletal Proteins - immunology ; Desmoglein 1 ; Desmoglein 3 ; Desmogleins ; Desmoplakins ; Enzyme-Linked Immunosorbent Assay ; Female ; Fluorescent Antibody Technique, Indirect ; Histocompatibility Testing ; Humans ; Immunoblotting ; Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.) ; Male ; Medical sciences ; Middle Aged ; Pemphigoid, Bullous - immunology ; Silicosis - immunology ; Silicosis - pathology ; Toxicology</subject><ispartof>Dermatology (Basel), 2001-01, Vol.202 (1), p.16-21</ispartof><rights>2001 S. Karger AG, Basel</rights><rights>2001 INIST-CNRS</rights><rights>Copyright (c) 2001 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-280e4ab97220e4304fe0ce5fa06486c3cc7a0692bcb53ab7c64bf155bce0336b3</citedby><cites>FETCH-LOGICAL-c416t-280e4ab97220e4304fe0ce5fa06486c3cc7a0692bcb53ab7c64bf155bce0336b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=924593$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11244222$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ueki, H.</creatorcontrib><creatorcontrib>Kohda, M.</creatorcontrib><creatorcontrib>Nobutoh, T.</creatorcontrib><creatorcontrib>Yamaguchi, M.</creatorcontrib><creatorcontrib>Omori, K.</creatorcontrib><creatorcontrib>Miyashita, Y.</creatorcontrib><creatorcontrib>Hashimoto, T.</creatorcontrib><creatorcontrib>Komai, A.</creatorcontrib><creatorcontrib>Tomokuni, A.</creatorcontrib><creatorcontrib>Ueki, A.</creatorcontrib><title>Antidesmoglein Autoantibodies in Silicosis Patients with No Bullous Diseases</title><title>Dermatology (Basel)</title><addtitle>Dermatology</addtitle><description>Background: Pemphigus is an autoimmune bullous disease characterized by the presence of antidesmoglein autoantibodies. However, the mechanism of its autoantibody production remains unknown. In previous reports, we have described rare cases of pemphigus and pemphigoid associated with silicosis. It is well known that during long-term silicosis, some autoimmune diseases, such as systemic sclerosis, systemic lupus erythematosus or rheumatoid arthritis, can occur. Objective: The aim of this study was to explore the presence of pemphigus or pemphigoid autoantibodies in silicosis patients without clinical bullous diseases or collagen diseases. Method: The presence of pemphigus antibodies was examined in 54 silicosis patients with no associated bullous diseases, using immunofluorescence, the enzyme-linked immunosorbent assay (ELISA) for desmoglein 1 and 3, and immunoblotting methods. In the antibody-positive cases, HLA genotyping of peripheral lymphocytes was performed with PCR-RFLP. Results: Seven out of the 54 patients were found to be positive for pemphigus antibodies and 1 for bullous pemphigoid by immunofluorescence. In addition, by ELISA, 6 patients were found to be positive against the desmoglein 1 antigen, 2 against the desmoglein 3 antigen and 2 against both desmoglein 1 and desmoglein 3. Conclusion: The results of the present study strongly suggest the occurrence of pemphigus and pemphigoid autoantibodies in patients with silicosis. It remains unclear whether such patients will develop an autoimmune bullous disease in the future. Accordingly, long-term follow-up of antibody-positive patients is required.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Autoantibodies - blood</subject><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Clinical and Laboratory Investigations</subject><subject>Cytoskeletal Proteins - immunology</subject><subject>Desmoglein 1</subject><subject>Desmoglein 3</subject><subject>Desmogleins</subject><subject>Desmoplakins</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Fluorescent Antibody Technique, Indirect</subject><subject>Histocompatibility Testing</subject><subject>Humans</subject><subject>Immunoblotting</subject><subject>Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pemphigoid, Bullous - immunology</subject><subject>Silicosis - immunology</subject><subject>Silicosis - pathology</subject><subject>Toxicology</subject><issn>1018-8665</issn><issn>1421-9832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpt0MtP3DAQB2ALUfHYcugZqYpAQuKQ4neS4_IoRVoeAnqObO8EDNl48SRC_e9russiVfji0cwne_Qj5BujPxhT1RFNRzFVlGtki0nO8qoUfD3VlJV5qbXaJNuIT0nxsqg2yCZjXErO-RaZjLveTwFn4aEF32XjoQ8mtWyYesAsde58611Aj9mN6T10PWavvn_MrkJ2PLRtGDA79QgGAb-SL41pEXaW94j8_nl2f_Irn1yfX5yMJ7mTTPc5LylIY6uC81QIKhugDlRjqJaldsK5IpUVt84qYWzhtLQNU8o6oEJoK0bkYPHuPIaXAbCvZx4dtK3pIO1Tc1oxzVIII7L3H3wKQ-zSbjUvFONKFyqhwwVyMSBGaOp59DMT_9SM1m_51qt8k_2-fHCwM5h-yGWgCewvgUFn2iaaznlcuYpLVYmkdhfq2cQHiKvx-yd7n05Pby__gXo-bcRfccuVXA</recordid><startdate>200101</startdate><enddate>200101</enddate><creator>Ueki, H.</creator><creator>Kohda, M.</creator><creator>Nobutoh, T.</creator><creator>Yamaguchi, M.</creator><creator>Omori, K.</creator><creator>Miyashita, Y.</creator><creator>Hashimoto, T.</creator><creator>Komai, A.</creator><creator>Tomokuni, A.</creator><creator>Ueki, A.</creator><general>Karger</general><general>S. 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Toxic occupational diseases</topic><topic>Clinical and Laboratory Investigations</topic><topic>Cytoskeletal Proteins - immunology</topic><topic>Desmoglein 1</topic><topic>Desmoglein 3</topic><topic>Desmogleins</topic><topic>Desmoplakins</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Fluorescent Antibody Technique, Indirect</topic><topic>Histocompatibility Testing</topic><topic>Humans</topic><topic>Immunoblotting</topic><topic>Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pemphigoid, Bullous - immunology</topic><topic>Silicosis - immunology</topic><topic>Silicosis - pathology</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ueki, H.</creatorcontrib><creatorcontrib>Kohda, M.</creatorcontrib><creatorcontrib>Nobutoh, T.</creatorcontrib><creatorcontrib>Yamaguchi, M.</creatorcontrib><creatorcontrib>Omori, K.</creatorcontrib><creatorcontrib>Miyashita, Y.</creatorcontrib><creatorcontrib>Hashimoto, T.</creatorcontrib><creatorcontrib>Komai, A.</creatorcontrib><creatorcontrib>Tomokuni, A.</creatorcontrib><creatorcontrib>Ueki, A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Dermatology (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ueki, H.</au><au>Kohda, M.</au><au>Nobutoh, T.</au><au>Yamaguchi, M.</au><au>Omori, K.</au><au>Miyashita, Y.</au><au>Hashimoto, T.</au><au>Komai, A.</au><au>Tomokuni, A.</au><au>Ueki, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antidesmoglein Autoantibodies in Silicosis Patients with No Bullous Diseases</atitle><jtitle>Dermatology (Basel)</jtitle><addtitle>Dermatology</addtitle><date>2001-01</date><risdate>2001</risdate><volume>202</volume><issue>1</issue><spage>16</spage><epage>21</epage><pages>16-21</pages><issn>1018-8665</issn><eissn>1421-9832</eissn><abstract>Background: Pemphigus is an autoimmune bullous disease characterized by the presence of antidesmoglein autoantibodies. However, the mechanism of its autoantibody production remains unknown. In previous reports, we have described rare cases of pemphigus and pemphigoid associated with silicosis. It is well known that during long-term silicosis, some autoimmune diseases, such as systemic sclerosis, systemic lupus erythematosus or rheumatoid arthritis, can occur. Objective: The aim of this study was to explore the presence of pemphigus or pemphigoid autoantibodies in silicosis patients without clinical bullous diseases or collagen diseases. Method: The presence of pemphigus antibodies was examined in 54 silicosis patients with no associated bullous diseases, using immunofluorescence, the enzyme-linked immunosorbent assay (ELISA) for desmoglein 1 and 3, and immunoblotting methods. In the antibody-positive cases, HLA genotyping of peripheral lymphocytes was performed with PCR-RFLP. Results: Seven out of the 54 patients were found to be positive for pemphigus antibodies and 1 for bullous pemphigoid by immunofluorescence. In addition, by ELISA, 6 patients were found to be positive against the desmoglein 1 antigen, 2 against the desmoglein 3 antigen and 2 against both desmoglein 1 and desmoglein 3. Conclusion: The results of the present study strongly suggest the occurrence of pemphigus and pemphigoid autoantibodies in patients with silicosis. It remains unclear whether such patients will develop an autoimmune bullous disease in the future. Accordingly, long-term follow-up of antibody-positive patients is required.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>11244222</pmid><doi>10.1159/000051578</doi><tpages>6</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Autoantibodies - blood Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Clinical and Laboratory Investigations Cytoskeletal Proteins - immunology Desmoglein 1 Desmoglein 3 Desmogleins Desmoplakins Enzyme-Linked Immunosorbent Assay Female Fluorescent Antibody Technique, Indirect Histocompatibility Testing Humans Immunoblotting Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.) Male Medical sciences Middle Aged Pemphigoid, Bullous - immunology Silicosis - immunology Silicosis - pathology Toxicology |
| title | Antidesmoglein Autoantibodies in Silicosis Patients with No Bullous Diseases |
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