Altered Ca Homeostasis in Human Uremic Skeletal Muscle: Possible Involvement of cADPR in Elevation of Intracellular Resting [Ca2+]

Background: Patients with chronic renal failure may develop muscle weakness and fatigability due to disorders of skeletal muscle function, collectively known as the uremic myopathy. Cyclic adenosine diphosphate-ribose (cADPR), an endogenous metabolite of beta -NAD+, activates Ca2+ release from intra...

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Veröffentlicht in:	Nephron. Physiology 2005-08, Vol.100 (4), p.p51-p60
Hauptverfasser:	Lopez, Jose R, Mijares, Alfredo, Rojas, Bianca, Linares, Nancy, Allen, Paul D, Shtifman, Alexander
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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