Effect of green and ripe Carica papaya epicarp extracts on wound healing and during pregnancy
The traditional use of papaya to treat many diseases, especially skin conditions and its prohibition for consumption during pregnancy has prompted us to determine whether papaya extracts both from green and ripe fruits improve wound healing and also produce foetal toxicity. Aqueous extracts of green...
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| Veröffentlicht in: | Food and chemical toxicology 2008-07, Vol.46 (7), p.2384-2389 |
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| creator | Anuar, Nor Suhada Zahari, Shafiyyah Solehah Taib, Ibrahim Adham Rahman, Mohammad Tariqur |
| description | The traditional use of papaya to treat many diseases, especially skin conditions and its prohibition for consumption during pregnancy has prompted us to determine whether papaya extracts both from green and ripe fruits improve wound healing and also produce foetal toxicity. Aqueous extracts of green papaya epicarp (GPE) and ripe papaya epicarp (RPE) were applied on induced wounds on mice. GPE treatment induced complete healing in shorter periods (13 days) than that required while using RPE (17 days), sterile water (18 days) and Solcoseryl ointment (21 days). Extracts were administered orally (1
mg/g body weight/day) to pregnant mice from day 10 and onwards after conception. 3 (
n
=
7) mice and 1 (
n
=
6) mice given RPE and misoprostol, an abortive drug, respectively experienced embryonic resorption while this effect was observed in none of the mice given GPE (
n
=
5) and water (
n
=
5). The average body weight of live pups delivered by mice given GPE (1.12
±
0.04
g) was significantly lower than those delivered by mice given water (1.38
±
0.02
g). In SDS–PAGE, proteins were distributed in three bands (
Mr range ∼8–29
kDa). Band intensity at
Mr ∼28–29
kDa was higher in GPE than in RPE. In contrast, band intensity at low
Mr (∼8
kDa) was found to be higher in RPE than in GPE. Notably, the band corresponding to
Mr ∼23–25
kDa was absent in RPE. These differences in composition may have contributed to the different wound healing and abortive effects of green and ripe papaya. |
| doi_str_mv | 10.1016/j.fct.2008.03.025 |
| format | Article |
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mg/g body weight/day) to pregnant mice from day 10 and onwards after conception. 3 (
n
=
7) mice and 1 (
n
=
6) mice given RPE and misoprostol, an abortive drug, respectively experienced embryonic resorption while this effect was observed in none of the mice given GPE (
n
=
5) and water (
n
=
5). The average body weight of live pups delivered by mice given GPE (1.12
±
0.04
g) was significantly lower than those delivered by mice given water (1.38
±
0.02
g). In SDS–PAGE, proteins were distributed in three bands (
Mr range ∼8–29
kDa). Band intensity at
Mr ∼28–29
kDa was higher in GPE than in RPE. In contrast, band intensity at low
Mr (∼8
kDa) was found to be higher in RPE than in GPE. Notably, the band corresponding to
Mr ∼23–25
kDa was absent in RPE. These differences in composition may have contributed to the different wound healing and abortive effects of green and ripe papaya.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/j.fct.2008.03.025</identifier><identifier>PMID: 18468758</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Abortifacient Agents - pharmacology ; Abortion ; Abortion, Induced ; Administration, Oral ; adverse effects ; Analysis of Variance ; animal models ; Animals ; Biological and medical sciences ; birth weight ; Birth Weight - drug effects ; Carica - chemistry ; Carica papaya ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Electrophoresis, Polyacrylamide Gel ; Embryo Loss - chemically induced ; embryonic mortality ; Embryonic resorption ; exocarp ; Female ; fetotoxicity ; Medical sciences ; medicinal properties ; Mice ; Mice, Inbred ICR ; Misoprostol - pharmacology ; Models, Animal ; oral administration ; Papaya ; papayas ; plant extracts ; Plant Extracts - pharmacology ; Plant Extracts - toxicity ; Pregnancy ; Random Allocation ; ripening ; SDS–PAGE ; Time Factors ; tissue repair ; topical application ; Toxicology ; Wound healing ; Wound Healing - drug effects ; Wound Healing - physiology</subject><ispartof>Food and chemical toxicology, 2008-07, Vol.46 (7), p.2384-2389</ispartof><rights>2008 Elsevier Ltd</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-f17a871e49a427960aa27aa88cbe34a9bf7831c976bce46428f5f20ab84c253d3</citedby><cites>FETCH-LOGICAL-c436t-f17a871e49a427960aa27aa88cbe34a9bf7831c976bce46428f5f20ab84c253d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.fct.2008.03.025$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20444265$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18468758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anuar, Nor Suhada</creatorcontrib><creatorcontrib>Zahari, Shafiyyah Solehah</creatorcontrib><creatorcontrib>Taib, Ibrahim Adham</creatorcontrib><creatorcontrib>Rahman, Mohammad Tariqur</creatorcontrib><title>Effect of green and ripe Carica papaya epicarp extracts on wound healing and during pregnancy</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>The traditional use of papaya to treat many diseases, especially skin conditions and its prohibition for consumption during pregnancy has prompted us to determine whether papaya extracts both from green and ripe fruits improve wound healing and also produce foetal toxicity. Aqueous extracts of green papaya epicarp (GPE) and ripe papaya epicarp (RPE) were applied on induced wounds on mice. GPE treatment induced complete healing in shorter periods (13 days) than that required while using RPE (17 days), sterile water (18 days) and Solcoseryl ointment (21 days). Extracts were administered orally (1
mg/g body weight/day) to pregnant mice from day 10 and onwards after conception. 3 (
n
=
7) mice and 1 (
n
=
6) mice given RPE and misoprostol, an abortive drug, respectively experienced embryonic resorption while this effect was observed in none of the mice given GPE (
n
=
5) and water (
n
=
5). The average body weight of live pups delivered by mice given GPE (1.12
±
0.04
g) was significantly lower than those delivered by mice given water (1.38
±
0.02
g). In SDS–PAGE, proteins were distributed in three bands (
Mr range ∼8–29
kDa). Band intensity at
Mr ∼28–29
kDa was higher in GPE than in RPE. In contrast, band intensity at low
Mr (∼8
kDa) was found to be higher in RPE than in GPE. Notably, the band corresponding to
Mr ∼23–25
kDa was absent in RPE. These differences in composition may have contributed to the different wound healing and abortive effects of green and ripe papaya.</description><subject>Abortifacient Agents - pharmacology</subject><subject>Abortion</subject><subject>Abortion, Induced</subject><subject>Administration, Oral</subject><subject>adverse effects</subject><subject>Analysis of Variance</subject><subject>animal models</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>birth weight</subject><subject>Birth Weight - drug effects</subject><subject>Carica - chemistry</subject><subject>Carica papaya</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>Embryo Loss - chemically induced</subject><subject>embryonic mortality</subject><subject>Embryonic resorption</subject><subject>exocarp</subject><subject>Female</subject><subject>fetotoxicity</subject><subject>Medical sciences</subject><subject>medicinal properties</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Misoprostol - pharmacology</subject><subject>Models, Animal</subject><subject>oral administration</subject><subject>Papaya</subject><subject>papayas</subject><subject>plant extracts</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - toxicity</subject><subject>Pregnancy</subject><subject>Random Allocation</subject><subject>ripening</subject><subject>SDS–PAGE</subject><subject>Time Factors</subject><subject>tissue repair</subject><subject>topical application</subject><subject>Toxicology</subject><subject>Wound healing</subject><subject>Wound Healing - drug effects</subject><subject>Wound Healing - physiology</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2O0zAUhS0EYsrAA7ABb2CX4L_YjliNquFHGokFzBJZN851cZUmwU6Avj0urWDHytfSd46uPxPynLOaM67f7Ovgl1owZmsmayaaB2TDrZGVlg1_SDZMGFvpljdX5EnOe8aY4UY_JlfcKm1NYzfk620I6Bc6BbpLiCOFsacpzki3kKIHOsMMR6A4l0uaKf5aEvgl02mkP6e1wN8Qhjju_gT7NZ3GOeFuhNEfn5JHAYaMzy7nNbl_d_tl-6G6-_T-4_bmrvJK6qUK3IA1HFULSphWMwBhAKz1HUoFbReMldy3RncelVbChiYIBp1VXjSyl9fk9bl3TtP3FfPiDjF7HAYYcVqzE6zlUklbQH4GfZpyThjcnOIB0tFx5k5O3d4Vp-7k1DHpitOSeXEpX7sD9v8SF4kFeHUBIHsYQipPj_kvJ5hSSuhT0cszF2BysEuFuf8sGJeMtUK3ShXi7ZnAIutHxOSyjzh67GMqv-T6Kf5n0d8i0p1F</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>Anuar, Nor Suhada</creator><creator>Zahari, Shafiyyah Solehah</creator><creator>Taib, Ibrahim Adham</creator><creator>Rahman, Mohammad Tariqur</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20080701</creationdate><title>Effect of green and ripe Carica papaya epicarp extracts on wound healing and during pregnancy</title><author>Anuar, Nor Suhada ; Zahari, Shafiyyah Solehah ; Taib, Ibrahim Adham ; Rahman, Mohammad Tariqur</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-f17a871e49a427960aa27aa88cbe34a9bf7831c976bce46428f5f20ab84c253d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Abortifacient Agents - pharmacology</topic><topic>Abortion</topic><topic>Abortion, Induced</topic><topic>Administration, Oral</topic><topic>adverse effects</topic><topic>Analysis of Variance</topic><topic>animal models</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>birth weight</topic><topic>Birth Weight - drug effects</topic><topic>Carica - chemistry</topic><topic>Carica papaya</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Electrophoresis, Polyacrylamide Gel</topic><topic>Embryo Loss - chemically induced</topic><topic>embryonic mortality</topic><topic>Embryonic resorption</topic><topic>exocarp</topic><topic>Female</topic><topic>fetotoxicity</topic><topic>Medical sciences</topic><topic>medicinal properties</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Misoprostol - pharmacology</topic><topic>Models, Animal</topic><topic>oral administration</topic><topic>Papaya</topic><topic>papayas</topic><topic>plant extracts</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - toxicity</topic><topic>Pregnancy</topic><topic>Random Allocation</topic><topic>ripening</topic><topic>SDS–PAGE</topic><topic>Time Factors</topic><topic>tissue repair</topic><topic>topical application</topic><topic>Toxicology</topic><topic>Wound healing</topic><topic>Wound Healing - drug effects</topic><topic>Wound Healing - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anuar, Nor Suhada</creatorcontrib><creatorcontrib>Zahari, Shafiyyah Solehah</creatorcontrib><creatorcontrib>Taib, Ibrahim Adham</creatorcontrib><creatorcontrib>Rahman, Mohammad Tariqur</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anuar, Nor Suhada</au><au>Zahari, Shafiyyah Solehah</au><au>Taib, Ibrahim Adham</au><au>Rahman, Mohammad Tariqur</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of green and ripe Carica papaya epicarp extracts on wound healing and during pregnancy</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>2008-07-01</date><risdate>2008</risdate><volume>46</volume><issue>7</issue><spage>2384</spage><epage>2389</epage><pages>2384-2389</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>The traditional use of papaya to treat many diseases, especially skin conditions and its prohibition for consumption during pregnancy has prompted us to determine whether papaya extracts both from green and ripe fruits improve wound healing and also produce foetal toxicity. Aqueous extracts of green papaya epicarp (GPE) and ripe papaya epicarp (RPE) were applied on induced wounds on mice. GPE treatment induced complete healing in shorter periods (13 days) than that required while using RPE (17 days), sterile water (18 days) and Solcoseryl ointment (21 days). Extracts were administered orally (1
mg/g body weight/day) to pregnant mice from day 10 and onwards after conception. 3 (
n
=
7) mice and 1 (
n
=
6) mice given RPE and misoprostol, an abortive drug, respectively experienced embryonic resorption while this effect was observed in none of the mice given GPE (
n
=
5) and water (
n
=
5). The average body weight of live pups delivered by mice given GPE (1.12
±
0.04
g) was significantly lower than those delivered by mice given water (1.38
±
0.02
g). In SDS–PAGE, proteins were distributed in three bands (
Mr range ∼8–29
kDa). Band intensity at
Mr ∼28–29
kDa was higher in GPE than in RPE. In contrast, band intensity at low
Mr (∼8
kDa) was found to be higher in RPE than in GPE. Notably, the band corresponding to
Mr ∼23–25
kDa was absent in RPE. These differences in composition may have contributed to the different wound healing and abortive effects of green and ripe papaya.</abstract><cop>Oxford</cop><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>18468758</pmid><doi>10.1016/j.fct.2008.03.025</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Food and chemical toxicology, 2008-07, Vol.46 (7), p.2384-2389 |
| issn | 0278-6915 1873-6351 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_20913438 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Abortifacient Agents - pharmacology Abortion Abortion, Induced Administration, Oral adverse effects Analysis of Variance animal models Animals Biological and medical sciences birth weight Birth Weight - drug effects Carica - chemistry Carica papaya Disease Models, Animal Dose-Response Relationship, Drug Electrophoresis, Polyacrylamide Gel Embryo Loss - chemically induced embryonic mortality Embryonic resorption exocarp Female fetotoxicity Medical sciences medicinal properties Mice Mice, Inbred ICR Misoprostol - pharmacology Models, Animal oral administration Papaya papayas plant extracts Plant Extracts - pharmacology Plant Extracts - toxicity Pregnancy Random Allocation ripening SDS–PAGE Time Factors tissue repair topical application Toxicology Wound healing Wound Healing - drug effects Wound Healing - physiology |
| title | Effect of green and ripe Carica papaya epicarp extracts on wound healing and during pregnancy |
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