Role of SmcHD1 in establishment of epigenetic states required for the maintenance of the X-inactivated state in mice

X inactivation in mammals is regulated by epigenetic modifications. Functional deficiency of SmcHD1 has been shown to cause de-repression of X-inactivated genes in post-implantation female mouse embryos, suggesting a role of SmcHD1 in the maintenance of X inactivation. Here, we show that de-repressi...

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Veröffentlicht in:	Development (Cambridge) 2018-12, Vol.145 (18)
Hauptverfasser:	Sakakibara, Yuki, Nagao, Koji, Blewitt, Marnie, Sasaki, Hiroyuki, Obuse, Chikashi, Sado, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism Embryo, Mammalian - embryology Epigenesis, Genetic - genetics Female Fibroblasts - cytology Genes, X-Linked - genetics Histones - genetics Histones - metabolism Mice Mice, Inbred C57BL Mice, Transgenic X Chromosome Inactivation - genetics
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