Synthesis of an oleic acid based pH-responsive lipid and its application in nanodelivery of vancomycin

[Display omitted] Stimuli-responsive nano-drug delivery systems can optimize antibiotic delivery to infection sites. Identifying novel lipids for pH responsive delivery to acidic conditions of infection sites will enhance the performance of nano-drug delivery systems. The aim of the present investig...

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Veröffentlicht in:	International journal of pharmaceutics 2018-10, Vol.550 (1-2), p.149-159
Hauptverfasser:	Mhule, Danford, Kalhapure, Rahul S., Jadhav, Mahantesh, Omolo, Calvin A., Rambharose, Sanjeev, Mocktar, Chunderika, Singh, Sanil, Waddad, Ayman Y., Ndesendo, Valence M.K., Govender, Thirumala
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - administration & dosage Antibiotic Antibiotic resistance Cell Line Drug Carriers Drug Liberation Humans Hydrogen-Ion Concentration Lipids Methicillin-resistant S. aureus Mice, Inbred BALB C Nanoparticles Nanotechnology NMEO Oleic Acid Particle Size pH responsive SLNs Skin - drug effects Vancomycin - administration & dosage
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