Decreased vesicular acetylcholine transporter related to memory deficits in epilepsy: A [18F] VAT positron emission tomography brain imaging study

Summary Objective Vesicular acetylcholine transporter (VAChT) is a rate‐limiting factor for synaptic acetylcholine transport. Our study focused on whether [18F] VAT, a novel positron emission tomography (PET) tracer, could be used in detecting cognitive deficits in epilepsy. Methods Morris water maz...

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Veröffentlicht in:	Epilepsia (Copenhagen) 2018-09, Vol.59 (9), p.1655-1666
Hauptverfasser:	Wu, Xu‐Qing, Zhao, Ya‐Nan, Ding, Jing, Si, Zhan, Cheng, Deng‐Feng, Shi, Hong‐Cheng, Wang, Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Acetylcholinesterase Acetyltransferase Acholeplasmataceae - metabolism Animal memory Animals Basal forebrain Brain - diagnostic imaging Brain - drug effects Chronic Disease Cognitive ability Disease Models, Animal Epilepsy Epilepsy - chemically induced Epilepsy - complications Epilepsy - diagnostic imaging Fluorodeoxyglucose F18 - pharmacokinetics Forebrain Hippocampus Immunofluorescence Learning Male Maze Learning - drug effects Memory memory deficit Memory Disorders - diagnostic imaging Memory Disorders - etiology Muscarinic Agonists - toxicity Naphthols - pharmacokinetics Neuroimaging Pilocarpine Pilocarpine - toxicity Piperidines - pharmacokinetics Positron emission tomography Rats Rats, Sprague-Dawley Rodents Septum Thalamus Vesicular Acetylcholine Transport Proteins - metabolism Vesicular acetylcholine transporter
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