Ultrasound Shear Wave Elastography as a Measure of Porcine Hepatic Disease in Right Heart Dysfunction: A Pilot Study
Patients with congenital heart disease with a pressure-overloaded right ventricle can develop liver disease and would benefit from non-invasive diagnostic modalities such as ultrasound shear wave elastography (US SWE). We sought to investigate the ability of US SWE to measure dynamic changes in live...
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| Veröffentlicht in: | Ultrasound in medicine & biology 2018-11, Vol.44 (11), p.2393-2399 |
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| creator | Hu, Jessie J. Qureshi, M. Yasir Urban, Matthew W. Graham, Rondell Yin, Meng Oommen, Saji Holst, Kimberly A. Edgerton, Sarah Vasconcelos, Luiz Nenadic, Ivan Cetta, Frank |
| description | Patients with congenital heart disease with a pressure-overloaded right ventricle can develop liver disease and would benefit from non-invasive diagnostic modalities such as ultrasound shear wave elastography (US SWE). We sought to investigate the ability of US SWE to measure dynamic changes in liver stiffness with an acute fluid bolus in an animal model. Three piglets underwent surgical intervention to create a pressure-overloaded right ventricle and, 12 wk later, underwent US SWE, both pre- and post-intravenous infusion of a saline bolus. Ultrasound measures of shear modulus, velocity and attenuation were taken to characterize hepatic mechanical properties. Liver stiffness exhibited a dynamic component that increased after fluid bolus, although not reaching statistical significance with our small sample size, and these changes were greater in more diseased livers. US SWE may provide a promising non-invasive method for assessing dynamic changes in hydration status and degree of liver disease. |
| doi_str_mv | 10.1016/j.ultrasmedbio.2018.05.027 |
| format | Article |
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Yasir ; Urban, Matthew W. ; Graham, Rondell ; Yin, Meng ; Oommen, Saji ; Holst, Kimberly A. ; Edgerton, Sarah ; Vasconcelos, Luiz ; Nenadic, Ivan ; Cetta, Frank</creator><creatorcontrib>Hu, Jessie J. ; Qureshi, M. Yasir ; Urban, Matthew W. ; Graham, Rondell ; Yin, Meng ; Oommen, Saji ; Holst, Kimberly A. ; Edgerton, Sarah ; Vasconcelos, Luiz ; Nenadic, Ivan ; Cetta, Frank ; for the Wanek Program Pre-clinical Pipeline ; Wanek Program Pre-clinical Pipeline</creatorcontrib><description>Patients with congenital heart disease with a pressure-overloaded right ventricle can develop liver disease and would benefit from non-invasive diagnostic modalities such as ultrasound shear wave elastography (US SWE). We sought to investigate the ability of US SWE to measure dynamic changes in liver stiffness with an acute fluid bolus in an animal model. Three piglets underwent surgical intervention to create a pressure-overloaded right ventricle and, 12 wk later, underwent US SWE, both pre- and post-intravenous infusion of a saline bolus. Ultrasound measures of shear modulus, velocity and attenuation were taken to characterize hepatic mechanical properties. Liver stiffness exhibited a dynamic component that increased after fluid bolus, although not reaching statistical significance with our small sample size, and these changes were greater in more diseased livers. US SWE may provide a promising non-invasive method for assessing dynamic changes in hydration status and degree of liver disease.</description><identifier>ISSN: 0301-5629</identifier><identifier>EISSN: 1879-291X</identifier><identifier>DOI: 10.1016/j.ultrasmedbio.2018.05.027</identifier><identifier>PMID: 30126621</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Animals ; Congenital heart disease ; Disease Models, Animal ; Elasticity Imaging Techniques - methods ; Fontan operation ; Heart Diseases - complications ; Liver - diagnostic imaging ; Liver - physiopathology ; Liver disease ; Liver Diseases - complications ; Liver Diseases - diagnostic imaging ; Liver Diseases - physiopathology ; Liver stiffness ; Pigs ; Pilot Projects ; Swine ; Ultrasound shear wave elastography</subject><ispartof>Ultrasound in medicine & biology, 2018-11, Vol.44 (11), p.2393-2399</ispartof><rights>2018</rights><rights>Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-268f4bf82ba8b02d1ebaa06dbf25f542e256b9339d49ea8f706db41703b093343</citedby><cites>FETCH-LOGICAL-c498t-268f4bf82ba8b02d1ebaa06dbf25f542e256b9339d49ea8f706db41703b093343</cites><orcidid>0000-0003-3810-8933 ; 0000-0003-1360-4287</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0301562918302357$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30126621$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, Jessie J.</creatorcontrib><creatorcontrib>Qureshi, M. 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US SWE may provide a promising non-invasive method for assessing dynamic changes in hydration status and degree of liver disease.</description><subject>Animals</subject><subject>Congenital heart disease</subject><subject>Disease Models, Animal</subject><subject>Elasticity Imaging Techniques - methods</subject><subject>Fontan operation</subject><subject>Heart Diseases - complications</subject><subject>Liver - diagnostic imaging</subject><subject>Liver - physiopathology</subject><subject>Liver disease</subject><subject>Liver Diseases - complications</subject><subject>Liver Diseases - diagnostic imaging</subject><subject>Liver Diseases - physiopathology</subject><subject>Liver stiffness</subject><subject>Pigs</subject><subject>Pilot Projects</subject><subject>Swine</subject><subject>Ultrasound shear wave elastography</subject><issn>0301-5629</issn><issn>1879-291X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE9vEzEQxS1ERUPhKyCLE5ddxt6_7q1qCkUqakWp4GbZ3nHjaLNObW-lfHucpiCOPY007817mh8hHxmUDFj7eV3OYwoqbnDQzpccWF9CUwLvXpEF6ztRcMF-vyYLqIAVTcvFMXkb4xoAurbq3pDjvOdty9mCpLunKD9PA71doQr0l3pEejGqmPx9UNvVjqpIFf2OKs4Bqbf0xgfjJqSXuFXJGbp0MYtI3UR_uPtVyoIKiS530c6TSc5Pp_SM3rjRJ3qb5mH3jhxZNUZ8_zxPyN2Xi5_nl8XV9ddv52dXhalFnwre9rbWtuda9Rr4wFArBe2gLW9sU3PkTatFVYmhFqh62-21mnVQacjrujohnw652-AfZoxJblw0OI5qQj9HyUEwXvGOi2w9PVhN8DEGtHIb3EaFnWQg99TlWv5PXe6pS2hkpp6PPzz3zDrL_07_Ys6G5cGA-dtHh0FG43AyOLiAJsnBu5f0_AFor5sc</recordid><startdate>201811</startdate><enddate>201811</enddate><creator>Hu, Jessie J.</creator><creator>Qureshi, M. 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Yasir ; Urban, Matthew W. ; Graham, Rondell ; Yin, Meng ; Oommen, Saji ; Holst, Kimberly A. ; Edgerton, Sarah ; Vasconcelos, Luiz ; Nenadic, Ivan ; Cetta, Frank</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-268f4bf82ba8b02d1ebaa06dbf25f542e256b9339d49ea8f706db41703b093343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Congenital heart disease</topic><topic>Disease Models, Animal</topic><topic>Elasticity Imaging Techniques - methods</topic><topic>Fontan operation</topic><topic>Heart Diseases - complications</topic><topic>Liver - diagnostic imaging</topic><topic>Liver - physiopathology</topic><topic>Liver disease</topic><topic>Liver Diseases - complications</topic><topic>Liver Diseases - diagnostic imaging</topic><topic>Liver Diseases - physiopathology</topic><topic>Liver stiffness</topic><topic>Pigs</topic><topic>Pilot Projects</topic><topic>Swine</topic><topic>Ultrasound shear wave elastography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Jessie J.</creatorcontrib><creatorcontrib>Qureshi, M. 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| subjects | Animals Congenital heart disease Disease Models, Animal Elasticity Imaging Techniques - methods Fontan operation Heart Diseases - complications Liver - diagnostic imaging Liver - physiopathology Liver disease Liver Diseases - complications Liver Diseases - diagnostic imaging Liver Diseases - physiopathology Liver stiffness Pigs Pilot Projects Swine Ultrasound shear wave elastography |
| title | Ultrasound Shear Wave Elastography as a Measure of Porcine Hepatic Disease in Right Heart Dysfunction: A Pilot Study |
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