Association between DNA Repair Gene Polymorphisms and p53 Alterations in Japanese Patients with Muscle-Invasive Bladder Cancer

Objective: DNA repair enzymes play a vital role in protecting the genome from carcinogens, several of which can cause mutations in the TP53 gene in bladder cancer. Some single nucleotide polymorphisms (SNPs) in DNA repair genes reportedly modulate the repair capacity. This study aimed to clarify the...

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Veröffentlicht in:	Pathobiology (Basel) 2006-01, Vol.73 (6), p.295-303
Hauptverfasser:	Sakano, Shigeru, Matsumoto, Hiroaki, Yamamoto, Yoshiaki, Kawai, Yoshihisa, Eguchi, Satoshi, Ohmi, Chietaka, Matsuyama, Hideyasu, Naito, Katsusuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Allelic Imbalance Asian Continental Ancestry Group - genetics Bladder cancer Cancer Deoxyribonucleic acid DNA DNA repair DNA Repair - genetics DNA-Binding Proteins - genetics Endonucleases - genetics Female Gene expression Gene Expression Regulation, Neoplastic Gene Frequency Genomics Genotype Humans Immunohistochemistry Japan Male Microsatellite Repeats Middle Aged Muscle, Smooth - pathology Mutation Neoplasm Invasiveness Nuclear Proteins - genetics Original Paper Pathology Polymorphism Polymorphism, Single Nucleotide Transcription Factors - genetics Tumor Suppressor Protein p53 - analysis Tumor Suppressor Protein p53 - genetics Urinary Bladder Neoplasms - chemistry Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - pathology X-ray Repair Cross Complementing Protein 1 Xeroderma Pigmentosum Group D Protein - genetics
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