Acute exacerbation of hepatitis due to reactivation of hepatitis B virus with mutations in the core region after chemotherapy for malignant lymphoma
A 43-year-old Japanese man who was positive for hepatitis B surface (HBs) antigen and HB e antibody, underwent chemotherapy for non-Hodgkin's lymphoma. After the chemotherapy he suffered from acute exacerbation of hepatitis because of reactivation of HBV. Recovery was achieved with interferon-a...
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| Veröffentlicht in: | Journal of gastroenterology 1997-10, Vol.32 (5), p.668-671 |
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| container_issue | 5 |
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| container_title | Journal of gastroenterology |
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| creator | Sato, T Kato, J Kawanishi, J Kogawa, K Ohya, M Sakamaki, S Niitsu, Y |
| description | A 43-year-old Japanese man who was positive for hepatitis B surface (HBs) antigen and HB e antibody, underwent chemotherapy for non-Hodgkin's lymphoma. After the chemotherapy he suffered from acute exacerbation of hepatitis because of reactivation of HBV. Recovery was achieved with interferon-alpha, glucagon-insulin therapy, and plasma exchange. Mutations were detected in codons 97, 100, 129, and 131 of the core region of HBV. The peptide encoded from the core region including such mutations possibly had greater antigenicity to induce cytotoxic T cell activity in the host. Core region mutations may be a crucial cause of the acute exacerbation of hepatitis B seen after chemotherapy. |
| doi_str_mv | 10.1007/BF02934119 |
| format | Article |
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After the chemotherapy he suffered from acute exacerbation of hepatitis because of reactivation of HBV. Recovery was achieved with interferon-alpha, glucagon-insulin therapy, and plasma exchange. Mutations were detected in codons 97, 100, 129, and 131 of the core region of HBV. The peptide encoded from the core region including such mutations possibly had greater antigenicity to induce cytotoxic T cell activity in the host. Core region mutations may be a crucial cause of the acute exacerbation of hepatitis B seen after chemotherapy.</description><identifier>ISSN: 0944-1174</identifier><identifier>EISSN: 1435-5922</identifier><identifier>DOI: 10.1007/BF02934119</identifier><identifier>PMID: 9349995</identifier><language>eng</language><publisher>Japan: Springer Nature B.V</publisher><subject>Acute Disease ; Adult ; Antigenicity ; Antineoplastic Combined Chemotherapy Protocols - adverse effects ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biopsy ; Chemotherapy ; Codons ; Cyclophosphamide - adverse effects ; Cyclophosphamide - therapeutic use ; Cytotoxicity ; DNA Primers - chemistry ; DNA, Viral - analysis ; Doxorubicin - adverse effects ; Doxorubicin - therapeutic use ; Follow-Up Studies ; Glucagon ; Glucosinolates - immunology ; Hepatitis B ; Hepatitis B - etiology ; Hepatitis B - pathology ; Hepatitis B Antibodies - analysis ; Hepatitis B Core Antigens - drug effects ; Hepatitis B Core Antigens - genetics ; Hepatitis B virus ; Hepatitis B virus - drug effects ; Hepatitis B virus - genetics ; Hepatitis B virus - growth & development ; Humans ; Insulin ; Lymphocytes T ; Lymphoma, Non-Hodgkin - drug therapy ; Male ; Mutation ; Mutation - genetics ; Non-Hodgkin's lymphoma ; Polymerase Chain Reaction ; Prednisone - adverse effects ; Prednisone - therapeutic use ; Vincristine - adverse effects ; Vincristine - therapeutic use ; Virus Activation - drug effects ; α-Interferon</subject><ispartof>Journal of gastroenterology, 1997-10, Vol.32 (5), p.668-671</ispartof><rights>Springer-Verlag 1997.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-452e41c5a64171f704a3822f2022ef302dfb2988850f7ca614752d9f7139ec8c3</citedby><cites>FETCH-LOGICAL-c370t-452e41c5a64171f704a3822f2022ef302dfb2988850f7ca614752d9f7139ec8c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9349995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sato, T</creatorcontrib><creatorcontrib>Kato, J</creatorcontrib><creatorcontrib>Kawanishi, J</creatorcontrib><creatorcontrib>Kogawa, K</creatorcontrib><creatorcontrib>Ohya, M</creatorcontrib><creatorcontrib>Sakamaki, S</creatorcontrib><creatorcontrib>Niitsu, Y</creatorcontrib><title>Acute exacerbation of hepatitis due to reactivation of hepatitis B virus with mutations in the core region after chemotherapy for malignant lymphoma</title><title>Journal of gastroenterology</title><addtitle>J Gastroenterol</addtitle><description>A 43-year-old Japanese man who was positive for hepatitis B surface (HBs) antigen and HB e antibody, underwent chemotherapy for non-Hodgkin's lymphoma. After the chemotherapy he suffered from acute exacerbation of hepatitis because of reactivation of HBV. Recovery was achieved with interferon-alpha, glucagon-insulin therapy, and plasma exchange. Mutations were detected in codons 97, 100, 129, and 131 of the core region of HBV. The peptide encoded from the core region including such mutations possibly had greater antigenicity to induce cytotoxic T cell activity in the host. Core region mutations may be a crucial cause of the acute exacerbation of hepatitis B seen after chemotherapy.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Antigenicity</subject><subject>Antineoplastic Combined Chemotherapy Protocols - adverse effects</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biopsy</subject><subject>Chemotherapy</subject><subject>Codons</subject><subject>Cyclophosphamide - adverse effects</subject><subject>Cyclophosphamide - therapeutic use</subject><subject>Cytotoxicity</subject><subject>DNA Primers - chemistry</subject><subject>DNA, Viral - analysis</subject><subject>Doxorubicin - adverse effects</subject><subject>Doxorubicin - therapeutic use</subject><subject>Follow-Up Studies</subject><subject>Glucagon</subject><subject>Glucosinolates - immunology</subject><subject>Hepatitis B</subject><subject>Hepatitis B - etiology</subject><subject>Hepatitis B - pathology</subject><subject>Hepatitis B Antibodies - analysis</subject><subject>Hepatitis B Core Antigens - drug effects</subject><subject>Hepatitis B Core Antigens - genetics</subject><subject>Hepatitis B virus</subject><subject>Hepatitis B virus - drug effects</subject><subject>Hepatitis B virus - genetics</subject><subject>Hepatitis B virus - growth & development</subject><subject>Humans</subject><subject>Insulin</subject><subject>Lymphocytes T</subject><subject>Lymphoma, Non-Hodgkin - drug therapy</subject><subject>Male</subject><subject>Mutation</subject><subject>Mutation - genetics</subject><subject>Non-Hodgkin's lymphoma</subject><subject>Polymerase Chain Reaction</subject><subject>Prednisone - adverse effects</subject><subject>Prednisone - therapeutic use</subject><subject>Vincristine - adverse effects</subject><subject>Vincristine - therapeutic use</subject><subject>Virus Activation - drug effects</subject><subject>α-Interferon</subject><issn>0944-1174</issn><issn>1435-5922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpt0U1LHDEYB_BQKna1vXgXAgUPwti8msnRXXwDwYs9D9nsk50sM5NpklH3e_iBjXWxUDzlgfyeF_gjdETJGSVE_ZpfEaa5oFR_QTMquKykZuwrmhEtREWpEt_QQUobQignst5H-0VrreUMvVzYKQOGZ2MhLk32YcDB4RbGUmef8GoCnAOOYGz2j5-AOX70cUr4yecW91P-SxL2A84tYBsilOb1W5txGSK2LfShfEUzbrELEfem8-vBDBl3235sQ2--oz1nugQ_du8h-n11-bC4qe7ur28XF3eV5YrkSkgGglppzgVV1CkiDK8Zc4wwBo4TtnJLpuu6lsQpa86pUJKttFOUa7C15Yfo5H3uGMOfCVJuep8sdJ0ZIEypYUQTLWte4M__4CZMcSi3NUzVZbEuJxR1-q5sDClFcM0YfW_itqGkeQuq-RdUwce7kdOyh9UH3SXDXwHqqY7f</recordid><startdate>19971001</startdate><enddate>19971001</enddate><creator>Sato, T</creator><creator>Kato, J</creator><creator>Kawanishi, J</creator><creator>Kogawa, K</creator><creator>Ohya, M</creator><creator>Sakamaki, S</creator><creator>Niitsu, Y</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7U9</scope></search><sort><creationdate>19971001</creationdate><title>Acute exacerbation of hepatitis due to reactivation of hepatitis B virus with mutations in the core region after chemotherapy for malignant lymphoma</title><author>Sato, T ; Kato, J ; Kawanishi, J ; Kogawa, K ; Ohya, M ; Sakamaki, S ; Niitsu, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-452e41c5a64171f704a3822f2022ef302dfb2988850f7ca614752d9f7139ec8c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Antigenicity</topic><topic>Antineoplastic Combined Chemotherapy Protocols - adverse effects</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biopsy</topic><topic>Chemotherapy</topic><topic>Codons</topic><topic>Cyclophosphamide - adverse effects</topic><topic>Cyclophosphamide - therapeutic use</topic><topic>Cytotoxicity</topic><topic>DNA Primers - chemistry</topic><topic>DNA, Viral - analysis</topic><topic>Doxorubicin - adverse effects</topic><topic>Doxorubicin - therapeutic use</topic><topic>Follow-Up Studies</topic><topic>Glucagon</topic><topic>Glucosinolates - immunology</topic><topic>Hepatitis B</topic><topic>Hepatitis B - etiology</topic><topic>Hepatitis B - pathology</topic><topic>Hepatitis B Antibodies - analysis</topic><topic>Hepatitis B Core Antigens - drug effects</topic><topic>Hepatitis B Core Antigens - genetics</topic><topic>Hepatitis B virus</topic><topic>Hepatitis B virus - drug effects</topic><topic>Hepatitis B virus - genetics</topic><topic>Hepatitis B virus - growth & development</topic><topic>Humans</topic><topic>Insulin</topic><topic>Lymphocytes T</topic><topic>Lymphoma, Non-Hodgkin - drug therapy</topic><topic>Male</topic><topic>Mutation</topic><topic>Mutation - genetics</topic><topic>Non-Hodgkin's lymphoma</topic><topic>Polymerase Chain Reaction</topic><topic>Prednisone - adverse effects</topic><topic>Prednisone - therapeutic use</topic><topic>Vincristine - adverse effects</topic><topic>Vincristine - therapeutic use</topic><topic>Virus Activation - drug effects</topic><topic>α-Interferon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sato, T</creatorcontrib><creatorcontrib>Kato, J</creatorcontrib><creatorcontrib>Kawanishi, J</creatorcontrib><creatorcontrib>Kogawa, K</creatorcontrib><creatorcontrib>Ohya, M</creatorcontrib><creatorcontrib>Sakamaki, S</creatorcontrib><creatorcontrib>Niitsu, Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Virology and AIDS Abstracts</collection><jtitle>Journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sato, T</au><au>Kato, J</au><au>Kawanishi, J</au><au>Kogawa, K</au><au>Ohya, M</au><au>Sakamaki, S</au><au>Niitsu, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute exacerbation of hepatitis due to reactivation of hepatitis B virus with mutations in the core region after chemotherapy for malignant lymphoma</atitle><jtitle>Journal of gastroenterology</jtitle><addtitle>J Gastroenterol</addtitle><date>1997-10-01</date><risdate>1997</risdate><volume>32</volume><issue>5</issue><spage>668</spage><epage>671</epage><pages>668-671</pages><issn>0944-1174</issn><eissn>1435-5922</eissn><abstract>A 43-year-old Japanese man who was positive for hepatitis B surface (HBs) antigen and HB e antibody, underwent chemotherapy for non-Hodgkin's lymphoma. After the chemotherapy he suffered from acute exacerbation of hepatitis because of reactivation of HBV. Recovery was achieved with interferon-alpha, glucagon-insulin therapy, and plasma exchange. Mutations were detected in codons 97, 100, 129, and 131 of the core region of HBV. The peptide encoded from the core region including such mutations possibly had greater antigenicity to induce cytotoxic T cell activity in the host. Core region mutations may be a crucial cause of the acute exacerbation of hepatitis B seen after chemotherapy.</abstract><cop>Japan</cop><pub>Springer Nature B.V</pub><pmid>9349995</pmid><doi>10.1007/BF02934119</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0944-1174 |
| ispartof | Journal of gastroenterology, 1997-10, Vol.32 (5), p.668-671 |
| issn | 0944-1174 1435-5922 |
| language | eng |
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| subjects | Acute Disease Adult Antigenicity Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biopsy Chemotherapy Codons Cyclophosphamide - adverse effects Cyclophosphamide - therapeutic use Cytotoxicity DNA Primers - chemistry DNA, Viral - analysis Doxorubicin - adverse effects Doxorubicin - therapeutic use Follow-Up Studies Glucagon Glucosinolates - immunology Hepatitis B Hepatitis B - etiology Hepatitis B - pathology Hepatitis B Antibodies - analysis Hepatitis B Core Antigens - drug effects Hepatitis B Core Antigens - genetics Hepatitis B virus Hepatitis B virus - drug effects Hepatitis B virus - genetics Hepatitis B virus - growth & development Humans Insulin Lymphocytes T Lymphoma, Non-Hodgkin - drug therapy Male Mutation Mutation - genetics Non-Hodgkin's lymphoma Polymerase Chain Reaction Prednisone - adverse effects Prednisone - therapeutic use Vincristine - adverse effects Vincristine - therapeutic use Virus Activation - drug effects α-Interferon |
| title | Acute exacerbation of hepatitis due to reactivation of hepatitis B virus with mutations in the core region after chemotherapy for malignant lymphoma |
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