COMT Inhibition by Tolcapone Further Improves Levodopa Pharmacokinetics when Combined with a Dual-Release Formulation of Levodopa/Benserazide

The objective of the study reported here was the investigation of the effect of catechol-O-methyl transferase (COMT) inhibition by tolcapone on the pharmacokinetics of levodopa and 3-O-methyldopa (3-OMD) after administration of a new dual-release formulation (dual-RF) of levodopa/benserazide (200/50...

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Veröffentlicht in:	European neurology 1999-01, Vol.41 (4), p.206-211
Hauptverfasser:	Gasser, U.E., Jorga, K., Crevoisier, C., Hovens, S.E.L., van Giersbergen, P.L.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Original Paper
Online-Zugang:	Volltext
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