Relationship between Blood Flow Kinetics and Severity of Alzheimer’s Disease: Assessment of Severity Using a Questionnaire-Type Examination, Alzheimer’s Disease Assessment Scale, Cognitive Sub-Scale (ADAScog)
We assessed hemokinetics associated with changes in Alzheimer’s disease (AD) severity in 90 AD patients by researching the relationship between AD Assessment Scale, cognitive sub-scale (ADAS cog ) scores and regional cerebral blood flow (rCBF). In the present study, we employed the questionnaire-typ...
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| Veröffentlicht in: | Dementia and geriatric cognitive disorders 2001-09, Vol.12 (5), p.318-325 |
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| creator | Nebu, Akihiko Ikeda, Manabu Fukuhara, Ryuji Shigenobu, Kazue Maki, Naruhiko Hokoishi, Kazuhiko Komori, Kenjiro Yasuoka, Takuo Tanabe, Hirotaka |
| description | We assessed hemokinetics associated with changes in Alzheimer’s disease (AD) severity in 90 AD patients by researching the relationship between AD Assessment Scale, cognitive sub-scale (ADAS cog ) scores and regional cerebral blood flow (rCBF). In the present study, we employed the questionnaire-type ADAS cog examination to accurately assess the severity of AD. Between five groups classified on the basis of ADAS cog score, significant differences were observed in parietal, lateral temporal and superior frontal rCBF. In addition, in parietal and lateral temporal regions, significant correlations were also observed between ADAS cog score and rCBF. In superior frontal rCBF, significant differences were noted only between group 5 (≥40 ADAS cog points) and each of the other groups; there was no significant correlation between rCBF and ADAS cog score. Thus, we propose the following mechanism for blood flow kinetics associated with changed severity: In an early stage of AD, blood flow in the medial temporal cortex is impaired, and gradually involves the temporoparietal regions. While the medial temporal impairment of blood flow reaches a plateau, temporoparietal blood flow continues to be impaired well into a severe stage, at which point blood flow impairment in the frontal region is initiated. |
| doi_str_mv | 10.1159/000051277 |
| format | Article |
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In the present study, we employed the questionnaire-type ADAS cog examination to accurately assess the severity of AD. Between five groups classified on the basis of ADAS cog score, significant differences were observed in parietal, lateral temporal and superior frontal rCBF. In addition, in parietal and lateral temporal regions, significant correlations were also observed between ADAS cog score and rCBF. In superior frontal rCBF, significant differences were noted only between group 5 (≥40 ADAS cog points) and each of the other groups; there was no significant correlation between rCBF and ADAS cog score. Thus, we propose the following mechanism for blood flow kinetics associated with changed severity: In an early stage of AD, blood flow in the medial temporal cortex is impaired, and gradually involves the temporoparietal regions. While the medial temporal impairment of blood flow reaches a plateau, temporoparietal blood flow continues to be impaired well into a severe stage, at which point blood flow impairment in the frontal region is initiated.</description><identifier>ISSN: 1420-8008</identifier><identifier>EISSN: 1421-9824</identifier><identifier>DOI: 10.1159/000051277</identifier><identifier>PMID: 11455133</identifier><identifier>CODEN: DGCDFX</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer Disease - diagnostic imaging ; Alzheimer Disease - physiopathology ; Alzheimer Disease - psychology ; Analysis of Variance ; Biological and medical sciences ; Blood Flow Velocity - physiology ; Brain - diagnostic imaging ; Brain - physiopathology ; Cerebrovascular Circulation - physiology ; Female ; Geriatrics ; Humans ; Male ; Medical sciences ; Middle Aged ; Original Research Article ; Psychiatric Status Rating Scales ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Severity of Illness Index ; Surveys and Questionnaires ; Tomography, Emission-Computed, Single-Photon</subject><ispartof>Dementia and geriatric cognitive disorders, 2001-09, Vol.12 (5), p.318-325</ispartof><rights>2001 S. Karger AG, Basel</rights><rights>2001 INIST-CNRS</rights><rights>Copyright 2001 S. Karger AG, Basel</rights><rights>Copyright S. Karger AG Sep/Oct 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-a11a05cc4f511bd4f2a19d14cce0d68f4261994af4f86b8f60e530067edb41823</citedby><cites>FETCH-LOGICAL-c415t-a11a05cc4f511bd4f2a19d14cce0d68f4261994af4f86b8f60e530067edb41823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,2430,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1096207$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11455133$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nebu, Akihiko</creatorcontrib><creatorcontrib>Ikeda, Manabu</creatorcontrib><creatorcontrib>Fukuhara, Ryuji</creatorcontrib><creatorcontrib>Shigenobu, Kazue</creatorcontrib><creatorcontrib>Maki, Naruhiko</creatorcontrib><creatorcontrib>Hokoishi, Kazuhiko</creatorcontrib><creatorcontrib>Komori, Kenjiro</creatorcontrib><creatorcontrib>Yasuoka, Takuo</creatorcontrib><creatorcontrib>Tanabe, Hirotaka</creatorcontrib><title>Relationship between Blood Flow Kinetics and Severity of Alzheimer’s Disease: Assessment of Severity Using a Questionnaire-Type Examination, Alzheimer’s Disease Assessment Scale, Cognitive Sub-Scale (ADAScog)</title><title>Dementia and geriatric cognitive disorders</title><addtitle>Dement Geriatr Cogn Disord</addtitle><description>We assessed hemokinetics associated with changes in Alzheimer’s disease (AD) severity in 90 AD patients by researching the relationship between AD Assessment Scale, cognitive sub-scale (ADAS cog ) scores and regional cerebral blood flow (rCBF). 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While the medial temporal impairment of blood flow reaches a plateau, temporoparietal blood flow continues to be impaired well into a severe stage, at which point blood flow impairment in the frontal region is initiated.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - diagnostic imaging</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Alzheimer Disease - psychology</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity - physiology</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - physiopathology</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Female</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Original Research Article</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychology. 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Psychoanalysis. Psychiatry</topic><topic>Psychopathology. 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In the present study, we employed the questionnaire-type ADAS cog examination to accurately assess the severity of AD. Between five groups classified on the basis of ADAS cog score, significant differences were observed in parietal, lateral temporal and superior frontal rCBF. In addition, in parietal and lateral temporal regions, significant correlations were also observed between ADAS cog score and rCBF. In superior frontal rCBF, significant differences were noted only between group 5 (≥40 ADAS cog points) and each of the other groups; there was no significant correlation between rCBF and ADAS cog score. Thus, we propose the following mechanism for blood flow kinetics associated with changed severity: In an early stage of AD, blood flow in the medial temporal cortex is impaired, and gradually involves the temporoparietal regions. While the medial temporal impairment of blood flow reaches a plateau, temporoparietal blood flow continues to be impaired well into a severe stage, at which point blood flow impairment in the frontal region is initiated.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>11455133</pmid><doi>10.1159/000051277</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Karger Journals |
| subjects | Aged Aged, 80 and over Alzheimer Disease - diagnostic imaging Alzheimer Disease - physiopathology Alzheimer Disease - psychology Analysis of Variance Biological and medical sciences Blood Flow Velocity - physiology Brain - diagnostic imaging Brain - physiopathology Cerebrovascular Circulation - physiology Female Geriatrics Humans Male Medical sciences Middle Aged Original Research Article Psychiatric Status Rating Scales Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Severity of Illness Index Surveys and Questionnaires Tomography, Emission-Computed, Single-Photon |
| title | Relationship between Blood Flow Kinetics and Severity of Alzheimer’s Disease: Assessment of Severity Using a Questionnaire-Type Examination, Alzheimer’s Disease Assessment Scale, Cognitive Sub-Scale (ADAScog) |
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