The AMPA Antagonist ZK 200775 in Patients with Acute Ischaemic Stroke: A Double-Blind, Multicentre, Placebo-Controlled Safety and Tolerability Study

Background and Purpose: ZK 200775 is a selective competitive AMPA receptor antagonist. It has demonstrated neuroprotective efficacy in experimental models of stroke and tolerability in healthy volunteers. We tested the safety and tolerability of ZK 200775 in patients with acute ischaemic stroke. Met...

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Veröffentlicht in:	Cerebrovascular diseases (Basel, Switzerland) Switzerland), 2005-01, Vol.20 (5), p.304-309
Hauptverfasser:	Walters, M.R., Kaste, Markku, Lees, K.R., Diener, Hans C., Hommel, M., De Keyser, Jacques, Steiner, Heike, Versavel, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adult Aged Aged, 80 and over Blood Pressure - drug effects Brain Ischemia - drug therapy Electrocardiography - drug effects Humans Middle Aged Organophosphonates - administration & dosage Organophosphonates - adverse effects Organophosphonates - pharmacokinetics Original Paper Patient Compliance Quinoxalines - administration & dosage Quinoxalines - adverse effects Quinoxalines - pharmacokinetics Receptors, AMPA - antagonists & inhibitors Stroke - drug therapy Treatment Outcome
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