Investigations of the effects of the antimalarial drug dihydroartemisinin (DHA) using the Frog Embryo Teratogenesis Assay-Xenopus (FETAX)

Artemisinin derivatives are effective and safe drugs for treating malaria, but they are not recommended during the first trimester of pregnancy because of resorptions and abnormalities observed in animal reproduction studies. Previous studies in rats showed that artemisinin embryotoxicity derives fr...

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Veröffentlicht in:	Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2008-08, Vol.25 (4), p.433-441
Hauptverfasser:	Longo, Monica, Zanoncelli, Sara, Della Torre, Paola, Rosa, Francesco, Giusti, AnnaMaria, Colombo, Paolo, Brughera, Marco, Mazué, Guy, Olliaro, Piero
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimalarial drug Antimalarials - toxicity Anura Artemisinins - toxicity Biological and medical sciences Dihydroartemisinin Embryology: invertebrates and vertebrates. Teratology Embryotoxicity Erythrocyte Count Erythrocytes - cytology Erythrocytes - drug effects Erythrocytes - ultrastructure Female FETAX Fundamental and applied biological sciences. Psychology Medical sciences Microscopy, Electron, Transmission Plasmodium Red blood cells Teratology. Teratogens Toxicology Xenopus Xenopus laevis
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