Follicular dynamics of glycerophospholipid and sphingolipid metabolisms in polycystic ovary syndrome patients

[Display omitted] •UPLC-MS detected glycerolipid, glycerophospholipids, sphingolipids, and carboxylic acids were different in PCOS FF.•Reduced PGP and TG were related to lower fertilization rate in PCOS.•Decreased sphingolipids, glycerophospholipids, and fluctuated fatty acyls were related to other...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2019-01, Vol.185, p.142-149
Hauptverfasser:	Liu, Lingyan, Yin, Tai-lang, Chen, Yu, Li, Yinghuan, Yin, Lu, Ding, Jinli, Yang, Jing, Feng, Huai-L
Format:	Artikel
Sprache:	eng
Schlagworte:	Abundance Adult Carboxylic acids Embryonic Development - physiology Female Follicle Stimulating Hormone - analysis Follicle-stimulating hormone Follicles Follicular fluid Follicular Fluid - chemistry Glycerophospholipid Glycosphingolipids - metabolism Humans In vitro fertilization Lipid metabolism Liquid chromatography Luteinizing hormone Luteinizing Hormone - analysis Mass Spectrometry Mass spectroscopy Metabolic pathway Metabolism Metabolites Metabolomics Metaphase Oocyte quality Oocytes Oocytes - growth & development Oocytes - metabolism PCOS Phosphatidylglycerol Phosphatidylglycerols - analysis Phosphatidylglycerols - metabolism Polycystic ovary syndrome Polycystic Ovary Syndrome - pathology Reproduction Sphingolipid Sphingolipids Steroids Triglycerides - analysis Triglycerides - metabolism UPLC-MS
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