Early Morphological and Functional Reorganization of the Articular Cartilage in Rats with Experimental Osteoarthrosis of Different Genesis
Peculiarities of the morphology of some phenotypes of experimental osteoarthrosis was studied in experiments on rats. Reorganization of the knee articular cartilage of Wistar rats during aging (age-associated phenotype), obesity (metabolic phenotype), circulatory disturbances ( e.g ., chronic heart...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2018-08, Vol.165 (4), p.497-502 |
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| creator | Korochina, K. V. Chernysheva, T. V. Korochina, I. E. Polyakova, V. S. Shamaev, S. Yu |
| description | Peculiarities of the morphology of some phenotypes of experimental osteoarthrosis was studied in experiments on rats. Reorganization of the knee articular cartilage of Wistar rats during aging (age-associated phenotype), obesity (metabolic phenotype), circulatory disturbances (
e.g
., chronic heart failure), and their combinations (polymorbidity) was studied by hematoxylin and eosin staining, immunohistochemical staining for collagen II and caspase 3, and morphometry. High sensitivity of the cartilage to non-traumatic influence of different anthropomorphic factors was demonstrated; morphological changes in osteoarthrosis of different genesis. The most pronounced pathological changes were observed in polymorbid animals, which allowed developing a new pathogenetically substantiated model of nontraumatic osteoarthrosis. |
| doi_str_mv | 10.1007/s10517-018-4203-x |
| format | Article |
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e.g
., chronic heart failure), and their combinations (polymorbidity) was studied by hematoxylin and eosin staining, immunohistochemical staining for collagen II and caspase 3, and morphometry. High sensitivity of the cartilage to non-traumatic influence of different anthropomorphic factors was demonstrated; morphological changes in osteoarthrosis of different genesis. The most pronounced pathological changes were observed in polymorbid animals, which allowed developing a new pathogenetically substantiated model of nontraumatic osteoarthrosis.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-018-4203-x</identifier><identifier>PMID: 30121928</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animal experimentation ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Cartilage, Articular - cytology ; Cartilage, Articular - metabolism ; Cartilage, Articular - physiology ; Caspase 3 - metabolism ; Cell Biology ; Chondrocytes - cytology ; Chondrocytes - physiology ; Collagen ; Immunohistochemistry ; Internal Medicine ; Laboratory Medicine ; Male ; Obesity ; Osteoarthritis - metabolism ; Osteoarthritis - physiopathology ; Pathology ; Phenotype ; Physiological aspects ; Rats ; Rats, Wistar</subject><ispartof>Bulletin of experimental biology and medicine, 2018-08, Vol.165 (4), p.497-502</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>COPYRIGHT 2018 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-979b052887c9e6e247978a509d8342e51d2c66f20cc50071850f407404460e773</citedby><cites>FETCH-LOGICAL-c512t-979b052887c9e6e247978a509d8342e51d2c66f20cc50071850f407404460e773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-018-4203-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-018-4203-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30121928$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Korochina, K. V.</creatorcontrib><creatorcontrib>Chernysheva, T. V.</creatorcontrib><creatorcontrib>Korochina, I. E.</creatorcontrib><creatorcontrib>Polyakova, V. S.</creatorcontrib><creatorcontrib>Shamaev, S. Yu</creatorcontrib><title>Early Morphological and Functional Reorganization of the Articular Cartilage in Rats with Experimental Osteoarthrosis of Different Genesis</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>Peculiarities of the morphology of some phenotypes of experimental osteoarthrosis was studied in experiments on rats. Reorganization of the knee articular cartilage of Wistar rats during aging (age-associated phenotype), obesity (metabolic phenotype), circulatory disturbances (
e.g
., chronic heart failure), and their combinations (polymorbidity) was studied by hematoxylin and eosin staining, immunohistochemical staining for collagen II and caspase 3, and morphometry. High sensitivity of the cartilage to non-traumatic influence of different anthropomorphic factors was demonstrated; morphological changes in osteoarthrosis of different genesis. The most pronounced pathological changes were observed in polymorbid animals, which allowed developing a new pathogenetically substantiated model of nontraumatic osteoarthrosis.</description><subject>Animal experimentation</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cartilage, Articular - cytology</subject><subject>Cartilage, Articular - metabolism</subject><subject>Cartilage, Articular - physiology</subject><subject>Caspase 3 - metabolism</subject><subject>Cell Biology</subject><subject>Chondrocytes - cytology</subject><subject>Chondrocytes - physiology</subject><subject>Collagen</subject><subject>Immunohistochemistry</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Male</subject><subject>Obesity</subject><subject>Osteoarthritis - metabolism</subject><subject>Osteoarthritis - physiopathology</subject><subject>Pathology</subject><subject>Phenotype</subject><subject>Physiological aspects</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kt9qFDEUxgdR7Fp9AG8kIIg3U08yM5vM5bJuq1ApFL0OaebMTEo2WZMM3foIPrUZpooFkVwk5-T3fXD-FMVrCmcUgH-IFBrKS6CirBlU5fFJsaINr0rBGH1arCBDZS2EOClexHg7h7Cmz4uTCiijLROr4udOBXtPvvhwGL31g9HKEuU6cj45nYx3ObxGHwblzA81J4jvSRqRbEIyerIqkK3KT6sGJMaRa5UiuTNpJLvjAYPZo0vZ4yom9Jkbg48mzh4fTd9jyL_kAh3m5MviWa9sxFcP92nx7Xz3dfupvLy6-LzdXJa6oSyVLW9voGFCcN3iGlnNWy5UA20nqpphQzum1-uegdZNLpiKBvoaeA11vQbkvDot3i--h-C_TxiT3Juo0Vrl0E9RMmihYpTWkNG3Czooi9K43qeg9IzLTdOwlgO0dabO_kHl0-HeaO-wNzn_SPDuL8GIyqYxejvN7Y2PQbqAOrctBuzlIXdUhXtJQc4rIJcVkHkF5LwC8pg1bx7Km2722P1R_J55BtgCxPzlBgzy1k8hDzr-x_UXSg661w</recordid><startdate>20180801</startdate><enddate>20180801</enddate><creator>Korochina, K. V.</creator><creator>Chernysheva, T. V.</creator><creator>Korochina, I. E.</creator><creator>Polyakova, V. S.</creator><creator>Shamaev, S. Yu</creator><general>Springer US</general><general>Springer</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180801</creationdate><title>Early Morphological and Functional Reorganization of the Articular Cartilage in Rats with Experimental Osteoarthrosis of Different Genesis</title><author>Korochina, K. V. ; Chernysheva, T. V. ; Korochina, I. E. ; Polyakova, V. S. ; Shamaev, S. Yu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-979b052887c9e6e247978a509d8342e51d2c66f20cc50071850f407404460e773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animal experimentation</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cartilage, Articular - cytology</topic><topic>Cartilage, Articular - metabolism</topic><topic>Cartilage, Articular - physiology</topic><topic>Caspase 3 - metabolism</topic><topic>Cell Biology</topic><topic>Chondrocytes - cytology</topic><topic>Chondrocytes - physiology</topic><topic>Collagen</topic><topic>Immunohistochemistry</topic><topic>Internal Medicine</topic><topic>Laboratory Medicine</topic><topic>Male</topic><topic>Obesity</topic><topic>Osteoarthritis - metabolism</topic><topic>Osteoarthritis - physiopathology</topic><topic>Pathology</topic><topic>Phenotype</topic><topic>Physiological aspects</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Korochina, K. V.</creatorcontrib><creatorcontrib>Chernysheva, T. V.</creatorcontrib><creatorcontrib>Korochina, I. E.</creatorcontrib><creatorcontrib>Polyakova, V. S.</creatorcontrib><creatorcontrib>Shamaev, S. Yu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bulletin of experimental biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Korochina, K. V.</au><au>Chernysheva, T. V.</au><au>Korochina, I. E.</au><au>Polyakova, V. S.</au><au>Shamaev, S. 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e.g
., chronic heart failure), and their combinations (polymorbidity) was studied by hematoxylin and eosin staining, immunohistochemical staining for collagen II and caspase 3, and morphometry. High sensitivity of the cartilage to non-traumatic influence of different anthropomorphic factors was demonstrated; morphological changes in osteoarthrosis of different genesis. The most pronounced pathological changes were observed in polymorbid animals, which allowed developing a new pathogenetically substantiated model of nontraumatic osteoarthrosis.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>30121928</pmid><doi>10.1007/s10517-018-4203-x</doi><tpages>6</tpages></addata></record> |
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| subjects | Animal experimentation Animals Biomedical and Life Sciences Biomedicine Cartilage, Articular - cytology Cartilage, Articular - metabolism Cartilage, Articular - physiology Caspase 3 - metabolism Cell Biology Chondrocytes - cytology Chondrocytes - physiology Collagen Immunohistochemistry Internal Medicine Laboratory Medicine Male Obesity Osteoarthritis - metabolism Osteoarthritis - physiopathology Pathology Phenotype Physiological aspects Rats Rats, Wistar |
| title | Early Morphological and Functional Reorganization of the Articular Cartilage in Rats with Experimental Osteoarthrosis of Different Genesis |
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