Interferon α decreases expression of human scavenger receptor class BI, a possible HCV receptor in hepatocytes

Background: Infection with the hepatitis C virus (HCV) causes acute hepatitis. This disease has a high probability of becoming chronic and leading to cirrhosis, but a more deadly consequence is hepatocellular carcinoma. Interferon α (IFNα)-based treatment combined with ribavirin is the major therape...

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Veröffentlicht in:	Gut 2008-05, Vol.57 (5), p.664-671
Hauptverfasser:	Murao, K, Imachi, H, Yu, X, Cao, W M, Nishiuchi, T, Chen, K, Li, J, Ahmed, R A M, Wong, N C W, Ishida, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - metabolism Antiviral Agents - pharmacology Blotting, Western Cells, Cultured DNA, Viral - metabolism Female Gene Expression Regulation - physiology Hepacivirus - metabolism Hepatitis C - drug therapy Hepatitis C - metabolism Hepatitis C virus Hepatocytes - metabolism Hepatocytes - virology Humans Interferon-alpha - pharmacology Male Receptors, Virus - antagonists & inhibitors Reverse Transcriptase Polymerase Chain Reaction RNA, Viral - metabolism Scavenger Receptors, Class B - antagonists & inhibitors Scavenger Receptors, Class B - metabolism Tetraspanin 28 Viral Proteins - drug effects Virus Replication - drug effects
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