Influence of ferulic acid on nicotine-induced lipid peroxidation, DNA damage and inflammation in experimental rats as compared to N -acetylcysteine

Abstract We examined the effect of ferulic acid (FA), a naturally occurring phenolic compound on lipid peroxidation and endogenous antioxidant status, DNA damage and inflammation in nicotine-administered Wistar rats. The effect of FA against nicotine toxicity was compared with N -acetylcysteine (NAC...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Toxicology (Amsterdam) 2008-01, Vol.243 (3), p.317-329
Hauptverfasser:	Sudheer, Adluri Ram, Muthukumaran, Shanmugavel, Devipriya, Nagarajan, Devaraj, Halagowder, Menon, Venugopal P
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - administration & dosage Acetylcysteine - pharmacology Alkaline Phosphatase - blood Animals Antioxidants Antioxidants - administration & dosage Antioxidants - pharmacology Biological and medical sciences Blotting, Western Catalase - metabolism Comet Assay Coumaric Acids - administration & dosage Coumaric Acids - chemistry Coumaric Acids - pharmacology Cyclooxygenase 2 - metabolism Cyclooxygenase-2 DNA Damage - drug effects Emergency Ferulic acid Glutathione - blood Glutathione - metabolism Glutathione Peroxidase - blood Glutathione Peroxidase - metabolism Inflammation - chemically induced Inflammation - metabolism Inflammation - prevention & control Injections, Subcutaneous Intubation, Gastrointestinal L-Lactate Dehydrogenase - blood Lipid peroxidation Lipid Peroxidation - drug effects Male Medical sciences Micronuclei Molecular Structure NF-kappa B - metabolism Nf-κB Nicotine Nicotine - administration & dosage Nicotine - toxicity Rats Rats, Wistar Superoxide Dismutase - metabolism Thiobarbituric Acid Reactive Substances - metabolism Tobacco, tobacco smoking Toxicology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!