Novel desferrioxamine derivatives synthesized using the secondary metabolism-specific nitrous acid biosynthetic pathway in Streptomyces davawensis

Recently, a novel nitrous acid biosynthetic pathway composed of two enzymes was discovered to be involved in the biosynthesis of cremeomycin for the formation of its diazo group. In this pathway, CreE oxidizes l -aspartic acid to nitrosuccinic acid and CreD liberates nitrous acid from nitrosuccinic...

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Veröffentlicht in:	Journal of antibiotics 2018-11, Vol.71 (11), p.911-919
Hauptverfasser:	Hagihara, Ryota, Katsuyama, Yohei, Sugai, Yoshinori, Onaka, Hiroyasu, Ohnishi, Yasuo
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326/41 631/45/607 631/92/60 82/16 82/58 82/80 Acids Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Biosynthesis Biosynthetic Pathways Conjugation, Genetic Deferoxamine - analogs & derivatives Deferoxamine - chemistry Deferoxamine - metabolism Enzymes Escherichia coli Gene Expression Regulation, Bacterial Inactivation Life Sciences Medicinal Chemistry Metabolism Metabolites Microbiology Molecular Structure Multigene Family Nitrous Acid - metabolism Organic Chemistry Secondary Metabolism Secondary metabolites Smog Streptomyces - classification Streptomyces - metabolism
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