LncRNA SNHG16 reverses the effects of miR-15a/16 on LPS-induced inflammatory pathway

[Display omitted] •LncRNA SNHG16 can downregulate the expression levels of miR-15a/16.•TLR4 is a target gene of miR-15a/16.•SNHG16 regulate TLR4 by binding with miR-15a/16 in RAW264.7 cells.•SNHG16 reverses the effects of miR-15a/16 overexpression on the LPS-promoted TLR-4 signal. Nowadays, neonatal...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2018-10, Vol.106, p.1661-1667
Hauptverfasser:	Wang, Wenying, Lou, Chunyan, Gao, Jie, Zhang, Xiaomin, Du, Yaowu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Case-Control Studies Down-Regulation HEK293 Cells Humans Infant, Newborn Lipopolysaccharides - pharmacology Macrophages - drug effects Macrophages - metabolism Mice MicroRNAs - genetics MicroRNAs - metabolism miR-15a/16 Neonatal sepsis Neonatal Sepsis - blood Neonatal Sepsis - diagnosis Neonatal Sepsis - genetics RAW 264.7 Cells RNA, Long Noncoding - blood RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Signal Transduction - drug effects SNHG16 TLR4 Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism
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